Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 2, 2024

Improper management of diabetic wound effusion and disruption the endogenous electric field can lead to passive healing damaged tissue, affecting process tissue cascade repair. This study developed an extracellular matrix sponge scaffold (K1P6@Mxene) by incorporating Mxene into acellular dermal stroma-hydroxypropyl chitosan interpenetrating network structure. is designed couple with promote precise remodelling in wounds. The fibrous structure closely resembles that a natural matrix, providing conducive microenvironment for cells adhere grow, exchange oxygen. Additionally, inclusion enhances antibacterial activity(98.89%) electrical conductivity within scaffold. Simultaneously, K1P6@Mxene exhibits excellent water absorption (39 times) porosity (91%). It actively interacts guide cell migration growth on surface upon absorbing exudate. In vivo experiments, reduced inflammatory response wounds, increased collagen deposition arrangement, promoted microvascular regeneration, Facilitate expedited re-epithelialization minimize scar formation, accelerate wounds 7 days. Therefore, this scaffold, combined field, presents appealing approach comprehensive repair

Язык: Английский

---

Mxene enhanced shape memory polymer composites: The rise of MXenes as fillers for stimuli-responsive materials

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155154 - 155154

Опубликована: Сен. 1, 2024

Язык: Английский

---

Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

In recent years, the use of MXenes, a class two-dimensional materials composed transition metal carbides, nitrides, or carbonitrides, has shown significant promise in field skin wound healing. This review explores multifunctional properties focusing on their electrical conductivity, photothermal effects, and biocompatibility this field. MXenes have been utilized to develop advanced healing devices such as hydrogels, patches, smart bandages for examination. These offer enhanced antibacterial activity, promote tissue regeneration, provide real-time monitoring parameters. The highlights synthesis methods, chemical features, biological effects emphasizing role innovative repair strategies. Additionally, it discusses potential MXene-based sensors humidity, pH, temperature monitoring, which are crucial preventing infections complications integration into wearable represents advancement management, promising improved clinical outcomes quality life patients.

Язык: Английский

---

MXene-derived Multifunctional Biomaterials: New Opportunities for Wound Healing

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 1, 2025

The process of wound healing is frequently impeded by metabolic imbalances within the microenvironment. MXenes exhibit exceptional biocompatibility, biodegradability, photothermal conversion efficiency, conductivity, and adaptable surface functionalization, demonstrating marked potential in development multifunctional platforms for healing. Moreover, integration with other bioactive nanomaterials has been shown to enhance their therapeutic efficacy, paving way innovative approaches In this review, we provide a systematic exposition mechanisms through which facilitate offer comprehensive analysis current research landscape on MXene-based composites field. By delving into latest scientific discoveries, identify existing challenges future trajectories advancement MXenes. Our evaluation aims insightful guidance formulation more effective strategies.

Язык: Английский

---

Research progress on MXenes in polysaccharide-based hemostasis and wound healing: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140613 - 140613

Опубликована: Фев. 1, 2025

Язык: Английский

---

Selectively oxidized chitin as a degradable and biocompatible hemostat for uncontrolled bleeding and wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140906 - 140906

Опубликована: Фев. 10, 2025

Язык: Английский

---

Photodynamic antimicrobial nanocellulose-based paper with direct Z-scheme heterojunction for fruit freshkeeping

Chemical Engineering Journal, Год журнала: 2025, Номер 508, С. 161067 - 161067

Опубликована: Фев. 27, 2025

Язык: Английский

---

Integration of two-dimensional MXene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent Advances and Future Prospects

European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113512 - 113512

Опубликована: Окт. 1, 2024

Язык: Английский

---

Recent Advances in Potential Biomedical Applications of MXene‐Based Hydrogels

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)

Опубликована: Ноя. 29, 2024

ABSTRACT MXene‐based hydrogels represent a significant advancement in biomedical material science, leveraging the unique properties of 2D MXenes and versatile functionality hydrogels. This review discusses recent developments integration into hydrogel matrices, focusing on their applications such as wound healing, drug delivery, antimicrobial activity, tissue engineering, biosensing. MXenes, due to remarkable electrical conductivity, mechanical robustness, tunable surface chemistry, enhance properties, responsiveness environmental stimuli. Specifically, have shown great promise accelerating healing through photothermal effects, delivering drugs controlled manner, serving antibacterial agents. Their also enables targeted cancer therapies, including chemodynamic facilitated by high conductivity properties. Despite promising progress, challenges ensuring biocompatibility optimizing synthesis for large‐scale production remain. aims provide comprehensive overview current state applications, highlighting ongoing advancements potential future directions these multifunctional materials.

Язык: Английский

---

Multifunctional Nanofiber Membranes Constructed by Microfluidic Blow-Spinning to Inhibit Scar Formation at Early Intervention Stage

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(39), С. 53042 - 53059

Опубликована: Сен. 19, 2024

Pathological scarring has been a challenge in skin injury repair since ancient times, and prophylactic treatment the early stages of wound healing usually results delayed healing. In this study, poly(ethylene oxide) (PEO) chitosan (CTS) were used as carrier materials to construct multifunctional pirfenidone (PFD)/CTS/PEO (PCP) nanofiber membranes (NFMs) loaded with PFD by microfluidic blow-spinning (MBS). MBS is good method for quickly, safely, greenly constructing large-area manufacturing inexpensive NFMs. PCP NFMs uniform external morphology, diameters ranging from 200 500 nm. The encapsulation efficiency drug-loaded was above 80%, which had slow release, visualization, water absorption, biocompatibility. inhibitory effect on normal human dermal fibroblasts dose-dependent inhibited expression transforming growth factor-β1/SMAD family member 3 (TGF-β1/SMAD3) signaling pathway. showed significant antibacterial effects against both

Язык: Английский

---