Applied Sciences,
Год журнала:
2024,
Номер
14(21), С. 9892 - 9892
Опубликована: Окт. 29, 2024
Ulva
pertusa
Kjellman
(U.
pertusa)
is
a
seaweed
indigenous
to
the
intertidal
zone
of
Korean
coastline.
U.
exhibits
immune-enhancing
and
antitumor
activities,
its
effects
on
intestinal
health
have
gained
attention.
However,
mechanisms
underlying
beneficial
physiology
remain
elusive.
Here,
effect
intake
in
ameliorating
loperamide-induced
constipation
male
mice
was
evaluated.
Additionally,
cellular
levels
proinflammatory
cytokines,
including
nuclear
factor-kB
interleukin-1β,
were
assessed
decipher
intricate
interplay
between
inflammation
improvements
bowel
movement.
increased
fecal
weight
water
content
improved
transit
rate.
Moreover,
it
reduced
possibly
via
short-chain
fatty
acids
implicated
modulating
motility
mucosal
inflammation.
These
findings
underscore
efficacy
improving
functionality,
potential
constipation.
Marine Drugs,
Год журнала:
2025,
Номер
23(1), С. 38 - 38
Опубликована: Янв. 13, 2025
The
present
research
aimed
to
assess
the
anti-cancer
effects
of
polysaccharide
fraction
(SJP)
isolated
from
Saccharina
japonica.
release
immune-activating
cytokines,
including
IL-6,
IL-12,
and
TNF-α,
was
markedly
stimulated
by
SJP
in
a
concentration-dependent
manner
within
range
1
100
µg/mL.
Furthermore,
prophylactic
intravenous
(p.i.v.)
per
os
(p.p.o.)
injection
boosted
cytolytic
activity
mediated
NK
cells
CTLs
against
tumor
cells.
In
study
involving
Colon26-M3.1
carcinoma
as
lung
cancer
model,
both
p.i.v.
p.p.o.
exhibited
significant
anti-lung-cancer
effects.
Notably,
administration
at
dose
50
mg/kg
reduced
colonies
84%
40%,
respectively,
compared
control.
Moreover,
remained
substantial,
even
when
cell
function
inhibited
using
anti-asialo-GM1.
Fractionation
with
CaCl2
suggested
that
is
mixture
alginate
fucoidan.
fucoidan
immune
response
macrophages
more
strongly
than
fraction.
Consequently,
this
finding
S.
japonica
possesses
remarkable
through
activation
various
immunocytes.
addition,
indicates
potent
biological
may
be
attributed
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 257 - 257
Опубликована: Апрель 7, 2025
This
study
was
designed
to
investigate
the
immunostimulatory
and
anticancer
efficacies
of
pectic
polysaccharides
from
ginseng
leaves
treated
using
high-pressure
extraction
method
(HPEM).
The
isolation
HPEM
resulted
in
1.35-fold
higher
polysaccharide
yields
than
those
obtained
commonly
used
hot
water
method.
In
addition,
component
sugar
analysis
ginseng-leaf-derived
(GLHP)
showed
presence
nine
different
types
monosaccharides,
including
galacturonic
acid,
galactose,
rhamnose,
arabinose,
which
are
characteristic
polysaccharides.
GLHP
effectively
induced
activation
complement
system,
macrophages
stimulated
with
enhanced
production
cytokines
such
as
IL-6,
IL-12,
TNF-α.
Intravenous
(i.v.)
oral
administration
(p.o.)
significantly
increased
cancer-cell-killing
ability
spleen-derived
NK
cells.
a
lung-cancer-bearing
mouse
model
Colon26-M3.1
carcinoma,
prophylactic
i.v.
p.o.
potently
inhibited
95.2%
33.5%
lung
cancer,
respectively.
Furthermore,
significant
effects,
even
mice
cell
dysfunction,
via
anti-asialo
GM1
antibody.
These
effects
may
be
related
cytotoxic
T
lymphocytes
(CTL).
Therefore,
GLHP,
isolated
HPEM,
has
potent
effect,
these
closely
stimulation
various
immune
factors.
Marine Drugs,
Год журнала:
2024,
Номер
22(8), С. 336 - 336
Опубликована: Июль 25, 2024
The
term
"inflammatory
bowel
disease"
(IBD)
describes
a
class
of
relapse-remitting
conditions
that
affect
the
gastrointestinal
(GI)
tract.
Among
these,
Crohn's
disease
(CD)
and
ulcerative
colitis
(UC)
are
two
most
globally
prevalent
debilitating
conditions.
Several
articles
have
brought
attention
to
significant
role
inflammation
oxidative
stress
cooperatively
play
in
development
IBD,
offering
different
viewpoint
both
on
its
etiopathogenesis
strategies
for
effective
treatment
these
Marine
ecosystems
may
be
source
physiologically
active
substances,
supporting
search
new
potential
clinical
therapeutics.
Based
this
evidence,
review
aims
comprehensively
evaluate
activity
marine
algae
deriving
biomolecules
decreasing
pathological
features
CD
UC.
To
match
purpose,
deep
literature
PubMed
(MEDLINE)
Google
Scholar
was
performed
highlight
primary
biological
mechanisms,
modulation
inflammatory
biochemical
parameters,
benefits
from
species.
From
our
findings,
macroalgae
microalgae
shown
as
therapeutic
solutions
IBD
due
their
bioactive
compounds
anti-inflammatory
antioxidant
activities
which
capable
modulating
markers
such
cytokines,
NF-κB
pathway,
reactive
nitrosative
species
(ROS
RNS),
trefoil
factor
3
(TFF3),
lactoferrin,
SIRT1,
etc.
However,
while
we
found
promising
preclinical
more
extensive
long-term
studies
necessary
establish
efficacy
safety
treatment.
