Antimicrobial Zn2+-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds DOI Creative Commons
Svetlana Bratskaya, Andrey V. Boroda, Tamara Bogomaz

и другие.

Gels, Год журнала: 2024, Номер 10(12), С. 841 - 841

Опубликована: Дек. 20, 2024

The local application of broad-spectrum antibiotics via polymeric drug delivery systems is a promising alternative to their systemic administration in wound healing, prevention and treatment infections associated with surgical implants. However, low poorly controlled loading efficiency 100% burst release are common problems for the materials weak physical interaction between matrices. Here, we report new multifunctional carboxymethyl chitosan (CMC) cryogel, which efficiently prevents bacterial adhesion surface, kills bacteria solution ciprofloxacin (CIP), promotes fibroblast proliferation. suggested approach based on CIP Zn2+-chelated CMC cryogel ligand exchange reaction. We have shown that, due strong binding Zn2+ CMC, antibacterial effect toxicity fibroblasts CMC-Zn-CIP cryogels were mainly determined by content loaded CIP, can be precisely cryogel. containing 20 mgZn/g amounts sufficient completely suppress growth hospital strain Klebsiella oxytoca MIC 0.125 µg/mL, while maintaining viability at level 85–90%.

Язык: Английский

Multilevel Adaptive Monolithic Bone Mimics from Self-Bondable Organoapatite DOI
Lei Ma, Yunfei Tan,

Qiulan Tong

и другие.

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112271 - 112271

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Tetracarboxylic aromatic acid-based self-healing metallosupramolecular flexible nano-scaffold: Exploring rheological features, stimuli-responsiveness and anti-bacterial efficiency DOI
Biswajit Dey,

Subhajoy Sadhu,

Deblina Saha

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114571 - 114571

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 342, С. 103527 - 103527

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0
Carboxymethylated yeast β-glucan: Biological activity screening in zebrafish, sprayable hydrogel preparation, and wound healing study in diabetic mice DOI

Chunhua Xu,

Yongchun Zhang, Hui Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138178 - 138178

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

2
Antimicrobial Zn2+-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds DOI Creative Commons
Svetlana Bratskaya, Andrey V. Boroda, Tamara Bogomaz

и другие.

Gels, Год журнала: 2024, Номер 10(12), С. 841 - 841

Опубликована: Дек. 20, 2024

The local application of broad-spectrum antibiotics via polymeric drug delivery systems is a promising alternative to their systemic administration in wound healing, prevention and treatment infections associated with surgical implants. However, low poorly controlled loading efficiency 100% burst release are common problems for the materials weak physical interaction between matrices. Here, we report new multifunctional carboxymethyl chitosan (CMC) cryogel, which efficiently prevents bacterial adhesion surface, kills bacteria solution ciprofloxacin (CIP), promotes fibroblast proliferation. suggested approach based on CIP Zn2+-chelated CMC cryogel ligand exchange reaction. We have shown that, due strong binding Zn2+ CMC, antibacterial effect toxicity fibroblasts CMC-Zn-CIP cryogels were mainly determined by content loaded CIP, can be precisely cryogel. containing 20 mgZn/g amounts sufficient completely suppress growth hospital strain Klebsiella oxytoca MIC 0.125 µg/mL, while maintaining viability at level 85–90%.

Язык: Английский

Процитировано

0