Antimicrobial Zn2+-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds DOI Creative Commons
Svetlana Bratskaya, Andrey V. Boroda, Tamara Bogomaz

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 841 - 841

Published: Dec. 20, 2024

The local application of broad-spectrum antibiotics via polymeric drug delivery systems is a promising alternative to their systemic administration in wound healing, prevention and treatment infections associated with surgical implants. However, low poorly controlled loading efficiency 100% burst release are common problems for the materials weak physical interaction between matrices. Here, we report new multifunctional carboxymethyl chitosan (CMC) cryogel, which efficiently prevents bacterial adhesion surface, kills bacteria solution ciprofloxacin (CIP), promotes fibroblast proliferation. suggested approach based on CIP Zn2+-chelated CMC cryogel ligand exchange reaction. We have shown that, due strong binding Zn2+ CMC, antibacterial effect toxicity fibroblasts CMC-Zn-CIP cryogels were mainly determined by content loaded CIP, can be precisely cryogel. containing 20 mgZn/g amounts sufficient completely suppress growth hospital strain Klebsiella oxytoca MIC 0.125 µg/mL, while maintaining viability at level 85–90%.

Language: Английский

Multilevel Adaptive Monolithic Bone Mimics from Self-Bondable Organoapatite DOI
Lei Ma, Yunfei Tan,

Qiulan Tong

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112271 - 112271

Published: Feb. 1, 2025

Language: Английский

Citations

0
Tetracarboxylic aromatic acid-based self-healing metallosupramolecular flexible nano-scaffold: Exploring rheological features, stimuli-responsiveness and anti-bacterial efficiency DOI
Biswajit Dey,

Subhajoy Sadhu,

Deblina Saha

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571

Published: April 1, 2025

Language: Английский

Citations

0
State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103527 - 103527

Published: April 25, 2025

Language: Английский

Citations

0
Carboxymethylated yeast β-glucan: Biological activity screening in zebrafish, sprayable hydrogel preparation, and wound healing study in diabetic mice DOI

Chunhua Xu,

Yongchun Zhang, Hui Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138178 - 138178

Published: Nov. 28, 2024

Language: Английский

Citations

2
Antimicrobial Zn2+-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds DOI Creative Commons
Svetlana Bratskaya, Andrey V. Boroda, Tamara Bogomaz

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 841 - 841

Published: Dec. 20, 2024

The local application of broad-spectrum antibiotics via polymeric drug delivery systems is a promising alternative to their systemic administration in wound healing, prevention and treatment infections associated with surgical implants. However, low poorly controlled loading efficiency 100% burst release are common problems for the materials weak physical interaction between matrices. Here, we report new multifunctional carboxymethyl chitosan (CMC) cryogel, which efficiently prevents bacterial adhesion surface, kills bacteria solution ciprofloxacin (CIP), promotes fibroblast proliferation. suggested approach based on CIP Zn2+-chelated CMC cryogel ligand exchange reaction. We have shown that, due strong binding Zn2+ CMC, antibacterial effect toxicity fibroblasts CMC-Zn-CIP cryogels were mainly determined by content loaded CIP, can be precisely cryogel. containing 20 mgZn/g amounts sufficient completely suppress growth hospital strain Klebsiella oxytoca MIC 0.125 µg/mL, while maintaining viability at level 85–90%.

Language: Английский

Citations

0