Journal of Polymers and the Environment, Год журнала: 2024, Номер unknown
Опубликована: Окт. 24, 2024
Язык: Английский
Discover Materials, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 9, 2025
Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.
Язык: Английский
Процитировано
12
Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.
Язык: Английский
Процитировано
7
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141394 - 141394
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134962 - 134962
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
11
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 131 - 138
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
ABSTRACT Recently, there has been a surge in scholarly interest regarding the application of sophisticated materials technology to expedite wound healing, particularly through integration nanocomposites endowed with multifaceted functionalities augment efficacy care products. In order propose an external power‐free healing dressing electrical stimulation function, polyvinylidene fluoride (PVDF) nanofibers incorporating graphene oxide (GO) at varying concentrations were fabricated via electrospinning technique. Scanning electron microscopy (SEM) was employed reveal morphology composite nanofibers. Fourier transform infrared (FTIR) spectroscopy and X‐ray diffraction (XRD) analyses confirmed transition PVDF from α phase β phase. The antibacterial PVDF/GO against Staphylococcus aureus rigorously examined. Results indicated marked enhancement correlation increasing content GO. Moreover, piezoelectric property assessments, cytotoxicity, hemolysis tests meticulously performed. outcomes suggested that containing 0.5 w/w% GO (PVDF/GO‐0.5) demonstrated superior performance across all evaluated metrics, terms mechanical properties, characteristics, efficacy. These findings imply PVDF/GO‐0.5 possess capability mimic endogenous electric field, which is beneficial boost cellular migration proliferation, thereby accelerating process. Overall, innovative proposed this study can be considered highly promising candidate field tissue engineering.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Abstract Diabetic wounds, characterized by complex pathogenesis and high infection rates, pose significant challenges in treatment due to prolonged recovery times recurrence often leading severe complications such as amputation death. Traditional dry dressing treatments fail address the unique microenvironment of diabetic wounds tend cause secondary damage frequent replacement. In this study, an electronic‐embedding, drug‐loading hydrogel bioelectronics is reported for accelerating wound healing using a combination programmable pharmaceutical electrostimulative approaches. Encapsulated stretchable biocompatible materials, device capable multiple drug refilling accelerated release modulated on‐board electronics. vivo experiments on model rats confirm device's effectiveness promoting healing. This innovative approach implies potential improving management physical, material, interventions.
Язык: Английский
Процитировано
3
Biological and medical physics series, Год журнала: 2025, Номер unknown, С. 251 - 282
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер 10(9), С. 9088 - 9095
Опубликована: Фев. 26, 2025
This study successfully controlled the mechanical structure of chitosan films by regulating interactions between molecules through variations in concentration ratio citric and acetic acids within films. Additionally, precise drug release was achieved adjusting drying temperature during synthesis. The key issue addressed is challenge achieving control biodegradable materials. Inaccurate can lead to ineffective treatment or adverse side effects, limiting therapeutic efficacy increasing healthcare challenges. main objective fine-tune films' composition properties achieve predictable over ratios. Our results show that acid enhanced ratio, while higher temperatures reduced likely due structural changes film. Furthermore, caused varying enabled successful tensile strength strain we developed capable visually indicating color before after release, providing a simple effective method for real-time monitoring. Despite these promising results, challenges remain, such as improving biocompatibility use complex biological environments. Future research will focus on enhancing durability, conducting further tests systems, exploring methods increase their long-term performance.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106964 - 106964
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0