Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Language: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

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A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134962 - 134962

Published: Aug. 22, 2024

Language: Английский

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A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

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Composites for BTE

Biological and medical physics series, Journal Year: 2025, Volume and Issue: unknown, P. 251 - 282

Published: Jan. 1, 2025

Language: Английский

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Nanohydrogel mediated approaches for wound healing

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 138

Published: Jan. 1, 2025

Language: Английский

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Colorimetric Chitosan Films with Tunable Drug Release Ratio: Effect of Citric Acid and Acetic Acid Concentration Ratio and Drying Temperature

ACS Omega, Journal Year: 2025, Volume and Issue: 10(9), P. 9088 - 9095

Published: Feb. 26, 2025

This study successfully controlled the mechanical structure of chitosan films by regulating interactions between molecules through variations in concentration ratio citric and acetic acids within films. Additionally, precise drug release was achieved adjusting drying temperature during synthesis. The key issue addressed is challenge achieving control biodegradable materials. Inaccurate can lead to ineffective treatment or adverse side effects, limiting therapeutic efficacy increasing healthcare challenges. main objective fine-tune films' composition properties achieve predictable over ratios. Our results show that acid enhanced ratio, while higher temperatures reduced likely due structural changes film. Furthermore, caused varying enabled successful tensile strength strain we developed capable visually indicating color before after release, providing a simple effective method for real-time monitoring. Despite these promising results, challenges remain, such as improving biocompatibility use complex biological environments. Future research will focus on enhancing durability, conducting further tests systems, exploring methods increase their long-term performance.

Language: Английский

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Preparation and In Vitro Characterization of Polyvinylidene Fluoride/Graphene Oxide Composite Nanofibers for Potential Wound Healing Application

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

ABSTRACT Recently, there has been a surge in scholarly interest regarding the application of sophisticated materials technology to expedite wound healing, particularly through integration nanocomposites endowed with multifaceted functionalities augment efficacy care products. In order propose an external power‐free healing dressing electrical stimulation function, polyvinylidene fluoride (PVDF) nanofibers incorporating graphene oxide (GO) at varying concentrations were fabricated via electrospinning technique. Scanning electron microscopy (SEM) was employed reveal morphology composite nanofibers. Fourier transform infrared (FTIR) spectroscopy and X‐ray diffraction (XRD) analyses confirmed transition PVDF from α phase β phase. The antibacterial PVDF/GO against Staphylococcus aureus rigorously examined. Results indicated marked enhancement correlation increasing content GO. Moreover, piezoelectric property assessments, cytotoxicity, hemolysis tests meticulously performed. outcomes suggested that containing 0.5 w/w% GO (PVDF/GO‐0.5) demonstrated superior performance across all evaluated metrics, terms mechanical properties, characteristics, efficacy. These findings imply PVDF/GO‐0.5 possess capability mimic endogenous electric field, which is beneficial boost cellular migration proliferation, thereby accelerating process. Overall, innovative proposed this study can be considered highly promising candidate field tissue engineering.

Language: Английский

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Green-synthesized carbon quantum dots–silver nanocomposites for broad-spectrum antimicrobial and wound healing applications

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106964 - 106964

Published: April 1, 2025

Language: Английский

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Biomimetic surfactants for tunable interfacial properties in drug delivery, biomedical coatings and tissue engineering

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125658 - 125658

Published: April 1, 2025

Language: Английский

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