Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
289, С. 138633 - 138633
Опубликована: Дек. 13, 2024
Язык: Английский
Advances of naturally derived biomedical polymers in tissue engineering
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
The
extensive
utilization
of
natural
polymers
in
tissue
engineering
is
attributed
to
their
excellent
biocompatibility,
degradability,
and
resemblance
the
extracellular
matrix.
These
have
a
wide
range
applications
such
as
delivering
therapeutic
medicine,
detecting
diseases,
sensing
biological
substances,
promoting
regeneration,
treating
diseases.
This
brief
review
current
developments
properties
uses
widely
used
biomedical
derived
from
nature.
Additionally,
it
explores
correlation
between
characteristics
functions
these
materials
different
highlights
prospective
direction
for
advancement
polymer
engineering.
Язык: Английский
Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope Helicobacter pylori Vaccines in a BALB/c Mouse Model
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 132 - 132
Опубликована: Янв. 18, 2025
Background/Objectives:
Helicobacter
pylori
is
the
leading
cause
of
chronic
gastritis,
peptic
ulcer,
gastric
adenocarcinoma,
and
mucosal-associated
lymphoma.
Due
to
emerging
problems
with
antibiotic
treatment
against
H.
in
clinical
practice,
vaccination
has
gained
more
interest.
Oral
immunization
considered
a
promising
approach
for
preventing
initial
colonization
this
bacterium
gastrointestinal
tract,
establishing
first
line
defense
at
mucosal
surfaces.
Chitosan
nanoparticles
can
be
exploited
effectively
oral
vaccine
delivery
due
their
stability,
simplicity
target
accessibility,
beneficial
mucoadhesive
immunogenic
properties.
Methods:
In
study,
new
multi-epitope
pDNA-
recombinant
protein-based
vaccines
incorporating
multiple
antigens
were
produced
encapsulated
chitosan
intramuscular
administration.
The
induced
immune
response
was
assessed
through
levels
antigen-specific
IgGs,
secreted
SIgA,
cytokines
(IL-2,
IL-10,
IFN-γ)
immunized
BALB/C
mice.
Results:
Intramuscular
administration
both
pDNA
efficiently
stimulated
production
specific
IgG2a
IgG1,
which
supported
by
levels.
immunizations
either
or
protein
revealed
high
SIgA
levels,
suggesting
effective
immunization,
contrasting
immunizations,
did
not
induce
SIgA.
Conclusions:
These
findings
indicate
that
into
are
candidates
eradicating
mitigating
associated
diseases
humans.
Язык: Английский
Harnessing the immunomodulatory potential of chitosan and its derivatives for advanced biomedical applications
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142055 - 142055
Опубликована: Март 1, 2025
Язык: Английский
Nanotechnology-Driven Strategy Against SARS-CoV-2: Pluronic F127-Based Nanomicelles with or Without Atazanavir Reduce Viral Replication in Calu-3 Cells
Viruses,
Год журнала:
2025,
Номер
17(4), С. 518 - 518
Опубликована: Апрель 1, 2025
Despite
extensive
efforts,
no
highly
effective
antiviral
molecule
exists
for
treating
moderate
and
severe
COVID-19.
Nanotechnology
has
emerged
as
a
promising
approach
developing
novel
drug
delivery
systems
to
enhance
efficacy.
Among
these,
polymeric
nanomicelles
improve
the
solubility,
bioavailability,
cellular
uptake
of
therapeutic
agents.
In
this
study,
Pluronic
F127-based
were
developed
evaluated
their
activity
against
SARS-CoV-2.
The
nanomicelles,
formulated
using
direct
dissolution
method,
exhibited
an
average
size
37.4
±
8.01
nm
polydispersity
index
(PDI)
0.427
0.01.
Their
efficacy
was
assessed
in
SARS-CoV-2-infected
Vero
E6
Calu-3
cell
models,
where
treatment
with
1:2
dilution
inhibited
viral
replication
by
more
than
90%.
Cytotoxicity
assays
confirmed
non-toxic
both
lines
after
72
h.
cells
(human
type
II
pneumocyte
model),
containing
atazanavir
(ATV)
significantly
reduced
replication,
even
under
high
MOI
(2)
48
h,
while
also
preventing
IL-6
upregulation.
To
investigate
mechanism,
pretreatment
showed
inhibitory
effect.
However,
pre-exposure
led
significant
reduction
(>85%
>75%
1:4
dilutions,
respectively),
transmission
electron
microscopy.
These
findings
highlight
nanotechnology-driven
strategy
SARS-CoV-2,
reinforcing
potential
future
therapies.
Язык: Английский
Reducing Endotoxin Contamination in Chitosan: An Optimized Purification Method for Biomedical Applications
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2025,
Номер
unknown, С. 100797 - 100797
Опубликована: Апрель 1, 2025
Язык: Английский
Polysaccharide-Based Composite Systems in Bone Tissue Engineering: A Review
Materials,
Год журнала:
2024,
Номер
17(17), С. 4220 - 4220
Опубликована: Авг. 27, 2024
In
recent
years,
a
growing
demand
for
biomaterials
has
been
observed,
particularly
applications
in
bone
regenerative
medicine.
Bone
tissue
engineering
(BTE)
aims
to
develop
innovative
materials
and
strategies
repairing
regenerating
defects
injuries.
Polysaccharides,
due
their
biocompatibility,
biodegradability
as
well
bioactivity,
have
emerged
promising
candidates
scaffolds
or
composite
systems
BTE.
Polymers
combined
with
bioactive
ceramics
can
support
osteointegration.
Calcium
phosphate
(CaP)
be
broad
choice
an
inorganic
phase
that
stimulates
the
formation
of
new
apatite
layers.
This
review
provides
comprehensive
analysis
based
on
selected
polysaccharides
used
engineering,
highlighting
synthesis,
properties
applications.
Moreover,
applicability
produced
biocomposites
analyzed,
trends
modifying
endowing
them
functionalizations.
The
effects
these
composites
mechanical
properties,
biocompatibility
osteoconductivity
were
critically
analyzed.
article
summarizes
latest
manufacturing
methods
developments
polysaccharide-based
cartilage
regeneration
Язык: Английский