Breast Cancer Targets and Therapy,
Год журнала:
2024,
Номер
Volume 16, С. 23 - 39
Опубликована: Янв. 1, 2024
Objective:
Breast
cancer
is
the
second
most
common
malignancy
globally
and
a
leading
cause
of
death
in
women.
Analysis
factors
related
to
disease-free
survival
(DFS)
has
improved
understanding
disease
characteristics
recurrence.
The
aim
this
study
was
investigate
predictors
DFS
patients
with
breast
enable
identification
at
high
risk
who
may
benefit
from
prevention
interventions.
Methods:
We
retrospectively
analyzed
559
women
underwent
treatment
between
2004
2022.
endpoint
DFS.
Recurrence
defined
as
local
recurrence,
regional
distant
metastases,
contralateral
cancer,
other
primary
death.
Baseline
tumor-related
characteristics,
treatment-related
sociodemographic
biochemical
data
were
using
Cox
proportional
hazards
analysis.
Results:
median
45
months
(range,
2
225
months).
recurred
86
(15.4%),
whom
10
had
17
29
died.
Multivariate
forward
stepwise
regression
analysis
showed
that
AJCC
stage
III,
Ki67
≥
14%,
albumin,
platelet,
red
cell
distribution
width-standard
deviation
(RDW-SD)
worse
In
addition,
effects
RDW-SD
on
recurrence
confirmed
by
structural
equation
model
(SEM)
Conclusion:
addition
traditional
such
III
lower
pretreatment
circulating
higher
platelet
count
could
significantly
predict
study,
SEM
delineated
possible
causal
pathways
inter-relationships
contributing
among
Chinese
cancer.
Keywords:
RDW-SD,
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Авг. 8, 2023
Nanogels
are
highly
recognized
as
adaptable
drug
delivery
systems
that
significantly
contribute
to
improving
various
therapies
and
diagnostic
examinations
for
different
human
diseases.
These
three-dimensional,
hydrophilic
cross-linked
polymers
have
the
ability
absorb
large
amounts
of
water
or
biological
fluids.
Due
growing
demand
enhancing
current
therapies,
nanogels
emerged
next-generation
system.
They
effectively
address
limitations
conventional
therapy,
such
poor
stability,
particle
size,
low
loading
efficiency.
find
extensive
use
in
controlled
therapeutic
agents,
reducing
adverse
effects
enabling
lower
doses
while
maintaining
enhanced
efficacy
patient
compliance.
considered
an
innovative
system
highlights
shortcomings
traditional
methods.
This
article
covers
several
topics,
including
involvement
nanomedicine
sector,
their
advantages
limitations,
ideal
properties
like
biocompatibility,
biodegradability,
capacity,
permeability,
non-immunological
response,
colloidal
stability.
Additionally,
it
provides
information
on
nanogel
classification,
synthesis,
release
mechanisms,
applications.
The
also
discusses
barriers
associated
with
brain
targeting
progress
nanocarriers
delivering
agents
central
nervous
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Parkinson's
disease
(PD)
is
a
degenerative
neurological
condition
marked
by
the
gradual
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta.
The
precise
etiology
PD
remains
unclear,
but
emerging
evidence
suggests
significant
role
for
disrupted
autophagy-a
crucial
cellular
process
maintaining
protein
and
organelle
integrity.
Abstract
Brain
metastasis
(BrM)
is
a
major
problem
associated
with
cancer-related
mortality,
and
currently,
no
specific
biomarkers
are
available
in
clinical
settings
for
early
detection.
Liquid
biopsy
widely
accepted
as
non-invasive
method
diagnosing
cancer
other
diseases.
We
have
reviewed
the
evidence
that
shows
how
molecular
alterations
involved
BrM,
majorly
from
breast
(BC),
lung
(LC),
melanoma,
an
inception
they
can
be
employed
biomarker
development.
discussed
genetic
epigenetic
changes
influence
cells
to
breach
blood-brain
barrier
(BBB)
help
establish
metastatic
lesions
uniquely
distinct
brain
microenvironment.
Keeping
abreast
recent
breakthroughs
context
of
various
biomolecules
detections
identifications,
circulating
tumor
(CTC),
cell-free
nucleotides,
non-coding
RNAs,
secretory
proteins,
metabolites
pursued
human
body
fluids
such
blood,
serum,
cerebrospinal
fluid
(CSF),
urine
obtain
potential
candidates
The
liquid
biopsy-based
overlay
current
imaging
techniques
amplify
signal
viable
improving
detection
treatments
occult
BrM.
