Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats

Toxicology, Год журнала: 2024, Номер 504, С. 153766 - 153766

Опубликована: Март 1, 2024

Язык: Английский

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Ferroptosis as an emerging target in sickle cell disease

Current Research in Toxicology, Год журнала: 2024, Номер 7, С. 100181 - 100181

Опубликована: Янв. 1, 2024

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of death characterized reactive oxygen species (ROS) lipid peroxide accumulation, leading to damage impairments. The intricate interplay between iron, inflammation, oxidative stress SCD underscores the necessity thoroughly understanding these processes for development innovative therapeutic strategies. This review highlights importance balancing complex interactions among various factors exploitation knowledge developing novel therapeutics this devastating disease.

Язык: Английский

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Nrf2 activators for the treatment of rare iron overload diseases: from bench to bedside

Redox Biology, Год журнала: 2025, Номер 81, С. 103551 - 103551

Опубликована: Фев. 14, 2025

Iron overload and related oxidative damage are seen in many rare diseases, due to mutation of iron homeostasis-related genes. As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic levels by regulating iron-related genes pathways, making activators very good candidates for the treatment disorders. Successful examples include clinical use omaveloxolone Friedreich's Ataxia dimethyl fumarate relapsing-remitting multiple sclerosis. Despite these uses, therapeutic potentials disorders may be overlooked practice. Therefore, this study talks about potential use, possible mechanisms, precautions treating diseases. In addition, combination therapy with chelators is proposed reference, aiming facilitate more

Язык: Английский

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Mechanistic and Molecular Insights into Empagliflozin’s Role in Ferroptosis and Inflammation Trajectories in Acetaminophen-Induced Hepatotoxicity

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 405 - 405

Опубликована: Март 13, 2025

Background: Acetaminophen (APAP)-induced acute liver injury (ALI) is increasingly becoming a public health issue with high rate of morbidity and mortality. Therefore, there critical demand for finding protective modalities by understanding the underlying proposed mechanisms including, but not limited to, ferroptosis inflammation. Objectives: This study seeks to investigate possible hepatoprotective effect empagliflozin (EMPA) against APAP-induced ALI through modulation inflammatory cascades. Methods: Mice were allocated into following five groups: vehicle control, APAP, EMPA 10, 20 (10 mg/kg/day, respectively, P.O.), N-acetylcysteine (NAC, agent ALI). The hepatic was detected determining enzymes histopathological examination. Inflammation, oxidative stress, apoptosis, also evaluated. Results: APAP group showed an elevated level disrupted architecture. toxicity promoted inflammation, ferroptosis, as indicated cytokines, lipid peroxidation, reduced antioxidants, increased caspase-3, decreased Bcl-2, activation NF-κB/STAT3/hepcidin pathway. Pretreatment remarkably reversed these features, which reflected restoration histoarchitecture tissue, higher dose more efficient. Conclusions: can induce initiation conditions, favor ferroptosis. hindered unfavorable consequences; outcome indicates its anti-inflammatory, antioxidant, anti-apoptotic, anti-ferroptotic effects. modulatory action advocated potential agent.

Язык: Английский

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Iron as a Modifiable Factor for Adverse Pregnancy Outcomes: Refining and Understanding Causal Estimates Using Mendelian Randomization

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Язык: Английский

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Comprehensive review of leonurine: harnessing its therapeutic potential for chronic diseases

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

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The Regulatory Effects of Traditional Chinese Medicine on Ferroptosis

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 11

Опубликована: Сен. 19, 2022

Traditional Chinese medicine (TCM) has significantly contributed to protecting human health and promoting the progress of world civilization. A total 2,711 TCMs are included in 2020 version Pharmacopoeia, which is an integral part world's medical resources. Tu Youyou her team discovered purified artemisinin. And their contributions made values advantageous effects TCM more recognized by international community. There been a lot studies on treat diseases through antioxidant mechanisms, reports new mechanisms beyond antioxidants also increased year year. Recently, many appear have significant regulating ferroptosis. Ferroptosis iron-dependent, non-apoptotic, regulated cell death characterized intracellular lipid peroxide accumulation oxidative membrane damage. accumulating demonstrated that numerous organ injuries pathophysiological process companied with ferroptosis, such as cancer, neurodegenerative disease, acute renal injury, arteriosclerosis, diabetes, ischemia-reperfusion injury. This work mainly introduces dozens can regulate ferroptosis possible targets.

Язык: Английский

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Dissecting the potential role of ferroptosis in liver diseases: an updated review

Free Radical Research, Год журнала: 2023, Номер 57(4), С. 282 - 293

Опубликована: Апрель 3, 2023

Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic manner resulting from the intracellular accumulation large clusters reactive oxygen species (ROS) and lipid peroxides due to abnormal iron metabolism. Since liver main organ human body for storing iron, it essential perform in-depth investigation on role mechanistic basis ferroptosis in context divergent diseases. We previously summarized emerging among various diseases, however, past few years have been surge research establishing as molecular or treatment option. This review article concentrated accumulating progress range diseases such acute injury/failure (ALI/ALF), immune-mediated hepatitis, alcoholic disease (ALD), nonalcoholic fatty fibrosis. may be promising target prevention providing strategy exploring new therapeutic avenues these entities.

Язык: Английский

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Cross-talk between PPARγ, NF-κB, and p38 MAPK signaling mediates the ameliorating effects of bergenin against the iron overload-induced hepatotoxicity

Chemico-Biological Interactions, Год журнала: 2022, Номер 368, С. 110207 - 110207

Опубликована: Окт. 4, 2022

Язык: Английский

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Metabolic dysfunction-associated steatotic liver disease: ferroptosis related mechanisms and potential drugs

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 9, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a "multisystem" that simultaneously suffers from metabolic diseases and hepatic steatosis. Some may develop into fibrosis, cirrhosis, even hepatocellular carcinoma. Given the close connection between fatty liver, it urgent to identify drugs can control as whole delay progression. Ferroptosis, characterized by iron overload lipid peroxidation resulting abnormal metabolism, programmed cell death mechanism. It an important pathogenic mechanism in or become key direction for improving MASLD. In this article, we have summarized physiological pathological mechanisms of metabolism ferroptosis, well connections established through ferroptosis. We also MASLD therapeutic potential active substances targeting order provide readers with new insights. At same time, future clinical trials involving subjects (especially intervention drugs), detection serum levels ferroptosis markers patients should be increased further explore efficacy on

Язык: Английский

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