Chemosensors,
Год журнала:
2023,
Номер
11(4), С. 226 - 226
Опубликована: Апрель 6, 2023
Metal
ions
play
a
crucial
role
in
many
biochemical
processes,
and
when
state
of
scarcity
or
surplus,
they
can
lead
to
various
diseases.
Therefore,
the
development
selective,
sensitive,
cost-effective,
fast-responding
sensor
detect
metal
is
critical
for
vitro
medical
diagnostics.
In
recent
years,
fluorescent
sensors
have
been
extensively
investigated
as
potent
kits
effective
assessment
living
systems
due
their
high
sensitivity,
selectivity,
ability
perform
real-time,
non-invasive
monitoring,
versatility.
This
review
an
overview
advances
detection
imaging
biosystems
from
2018
date.
Specifically,
we
discuss
application
detecting
essential
non-essential
diagnostics,
cell
imaging,
vivo
imaging.
Finally,
summarize
remaining
challenges
offer
future
outlook
on
above
topics.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Complex
multicellular
organisms
are
composed
of
distinct
tissues
involving
specialized
cells
that
can
perform
specific
functions,
making
such
life
forms
possible.
Species
defined
by
their
genomes,
and
differences
between
individuals
within
a
given
species
directly
result
from
variations
in
genetic
codes.
While
alterations
give
rise
to
disease-causing
acquisitions
cell
identities,
it
is
now
well-established
biochemical
imbalances
also
lead
cellular
dysfunction
diseases.
Specifically,
nongenetic
chemical
events
orchestrate
metabolism
transcriptional
programs
govern
functional
identity.
Thus,
signaling,
which
broadly
defines
the
conversion
extracellular
signals
into
intracellular
changes,
contribute
acquisition
diseased
states.
Metal
ions
exhibit
unique
properties
be
exploited
cell.
For
instance,
metal
maintain
ionic
balance
cell,
coordinate
amino
acid
residues
or
nucleobases
altering
folding
function
biomolecules,
catalyze
reactions.
metals
essential
signaling
effectors
normal
physiology
disease.
Deciphering
ion
challenging
endeavor
illuminate
pathways
targeted
for
therapeutic
intervention.
Here,
we
review
key
processes
where
play
roles
describe
how
targeting
has
been
instrumental
dissecting
biochemistry
this
led
development
effective
strategies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15721 - 15721
Опубликована: Окт. 29, 2023
Trace
elements
and
metals
play
critical
roles
in
the
normal
functioning
of
central
nervous
system
(CNS),
their
dysregulation
has
been
implicated
neurodegenerative
disorders
such
as
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
In
a
healthy
CNS,
zinc,
copper,
iron,
manganese
vital
enzyme
cofactors,
supporting
neurotransmission,
cellular
metabolism,
antioxidant
defense.
Imbalances
these
trace
can
lead
to
oxidative
stress,
protein
aggregation,
mitochondrial
dysfunction,
thereby
contributing
neurodegeneration.
AD,
copper
zinc
imbalances
are
associated
with
amyloid-beta
tau
pathology,
impacting
cognitive
function.
PD
involves
disruption
iron
levels,
leading
damage
neuronal
loss.
Toxic
metals,
like
cadmium,
impair
synaptic
transmission
exacerbate
neuroinflammation,
CNS
health.
The
role
aluminum
AD
neurofibrillary
tangle
formation
also
noted.
Understanding
health
might
offer
potential
therapeutic
targets
for
disorders.
Codex
Alimentarius
standards
concerning
mentioned
foods
may
be
one
key
legal
contributions
safeguarding
public
Further
research
is
needed
fully
comprehend
complex
mechanisms
develop
effective
interventions.
Chemosensors,
Год журнала:
2023,
Номер
11(4), С. 226 - 226
Опубликована: Апрель 6, 2023
Metal
ions
play
a
crucial
role
in
many
biochemical
processes,
and
when
state
of
scarcity
or
surplus,
they
can
lead
to
various
diseases.
Therefore,
the
development
selective,
sensitive,
cost-effective,
fast-responding
sensor
detect
metal
is
critical
for
vitro
medical
diagnostics.
In
recent
years,
fluorescent
sensors
have
been
extensively
investigated
as
potent
kits
effective
assessment
living
systems
due
their
high
sensitivity,
selectivity,
ability
perform
real-time,
non-invasive
monitoring,
versatility.
This
review
an
overview
advances
detection
imaging
biosystems
from
2018
date.
Specifically,
we
discuss
application
detecting
essential
non-essential
diagnostics,
cell
imaging,
vivo
imaging.
Finally,
summarize
remaining
challenges
offer
future
outlook
on
above
topics.
