Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line DOI
Deepika Saini, Pankaj Kumar Chaudhary, Ganesh Kumar Verma

и другие.

Toxicology in Vitro, Год журнала: 2025, Номер unknown, С. 106082 - 106082

Опубликована: Май 1, 2025

Язык: Английский

Activation of lysosomal iron triggers ferroptosis in cancer DOI Creative Commons
Tatiana Cañeque, Leeroy Baron, Sebastian Müller

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Iron catalyses the oxidation of lipids in biological membranes and promotes a form cell death called ferroptosis1. Defining where this chemistry occurs can inform design drugs capable inducing or inhibiting ferroptosis various disease-relevant settings. Genetic approaches have revealed suppressors ferroptosis2-4; by contrast, small molecules provide spatiotemporal control at work5. Here we show that inhibitor liproxstatin-1 exerts cytoprotective effects inactivating iron lysosomes. We also inducer RSL3 initiates membrane lipid designed small-molecule activator lysosomal iron-fentomycin-1-to induce oxidative degradation phospholipids ultimately ferroptosis. Fentomycin-1 is able to kill iron-rich CD44high primary sarcoma pancreatic ductal adenocarcinoma cells, which promote metastasis fuel drug tolerance. In such regulates adaptation6,7 while conferring vulnerability ferroptosis8,9. Sarcoma cells exposed sublethal doses fentomycin-1 acquire ferroptosis-resistant state characterized downregulation mesenchymal markers activation membrane-damage response. This phospholipid degrader eradicate drug-tolerant persister cancer vitro reduces intranodal tumour growth mouse model breast metastasis. Together, these results reactivity confers therapeutic benefits, establish as druggable target highlight value targeting states10.

Язык: Английский

Процитировано

1
Copper-based nanoplatforms and their role in cancer therapy DOI
José I. García-Peiro, Javier Bonet-Aletá,

José L. Hueso

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216542 - 216542

Опубликована: Март 13, 2025

Язык: Английский

Процитировано

0
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis DOI

Wenqian Zheng,

Yang Liu, Jinru Liu

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137337 - 137337

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line DOI
Deepika Saini, Pankaj Kumar Chaudhary, Ganesh Kumar Verma

и другие.

Toxicology in Vitro, Год журнала: 2025, Номер unknown, С. 106082 - 106082

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0