Biomarkers of Fumonisin Exposure in Pigs Fed the Maximum Recommended Level in Europe
Toxins,
Год журнала:
2025,
Номер
17(2), С. 69 - 69
Опубликована: Фев. 4, 2025
This
study
investigated
biomarkers
of
fumonisin
exposure
in
pigs
fed
diets
contaminated
with
fumonisins
at
the
European
Union’s
maximum
recommended
level.
Pigs
were
assigned
to
either
a
(FB)
diet
or
plus
AlgoClay
(FB
+
AC)
for
durations
4,
9,
and
14
days.
At
days,
plasma
Sa1P:So1P
ratio
increased
FB
diet,
while
Sa:So
remained
unchanged.
In
liver,
FB1
was
detected
four
days
exposure,
concentration
tending
increase
through
day
14.
The
C22-24:C16
ratios
18:1-,
18:2-,
m18:1-ceramides
elevated
9
respectively.
kidneys,
only
detectable
18:1-ceramides
increased.
both
liver
attributed
reduction
C16
ceramides.
lungs,
no
detected;
however,
increased,
ceramide
concentrations
decreased
Feeding
AC
resulted
tissue-to-feed
kidneys
but
did
not
affect
ratios.
Interestingly,
decreases
ceramides
observed
group
longer
group.
Overall,
these
findings
highlight
complexity
relationship
between
tissue
sphingolipid
changes,
suggesting
that
comprehensive
analysis
multiple
is
required
fully
understand
fumonisin’s
effects.
Язык: Английский
Fumonisin Distorts the Cellular Membrane Lipid Profile: A Mechanistic Insight
Toxicology,
Год журнала:
2024,
Номер
506, С. 153860 - 153860
Опубликована: Июнь 12, 2024
Monitoring
modifications
in
membrane
lipids
association
with
external
stimuli/agents,
including
fumonisins
(FUMs),
is
a
widely
employed
approach
to
assess
cellular
metabolic
response/status.
FUMs
are
prevalent
fusariotoxins
worldwide
that
have
diverse
structures
varying
toxicity
across
species;
nevertheless,
they
can
induce
disturbances
and
disease,
cancer.
The
capacity
of
disrupt
lipids,
demonstrated
numerous
species
organs/tissues,
ascribed
multitude
factors/events,
which
range
from
direct
indirect
effects.
Certain
events
well
established,
whereas
the
potential
consequences
others
remain
speculative.
most
notable
effect
their
resemblance
sphingoid
bases,
impacts
synthesis
ceramides
leading
changes
lipids'
composition
not
limited
sphingolipids'
membranes.
next
plausible
scenario
involves
induction
oxidative
stress,
considered
an
indirect/secondary
FUMs.
Additional
modes
action
include
enzyme
activities
nuclear
signals
related
lipid
metabolism,
although
these
likely
yet
fully
comprehended.
This
review
provides
in-depth
insight
into
current
state
mechanistic
actions
modifying
focus
on
long-chain
fatty
acids.
paper
also
presents
detailed
description
reported
by
Язык: Английский
Effects of the Maximum Recommended Levels of Fumonisins in the EU on Oxylipin Profiles in the Liver and Brain of Chickens
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 19 - 19
Опубликована: Дек. 27, 2024
This
study
aimed
to
assess
the
effects
of
a
diet
containing
20.8
mg
FB1
+
FB2/kg
over
four
and
nine
days
on
oxylipin
(OL)
profiles
in
liver
brain
chickens.
A
total
96
OLs,
derived
from
seven
polyunsaturated
fatty
acids
(PUFAs)
via
cyclooxygenase
(COX),
lipoxygenase
(LOX),
cytochrome
P450
(P450),
non-enzymatic
pathways,
were
measured
using
HPLC-MS/MS.
In
liver,
significant
increase
epoxide
P450-derived
OLs
was
detected
by
day
4,
with
smaller
but
notable
increases
COX-
LOX-derived
9.
These
alterations
independent
whether
parent
PUFA
ω6
or
ω3.
However,
18-carbon
(C18)
PUFAs,
such
as
linoleic
acid
alpha-linolenic
acid,
showed
greater
compared
those
C20
C22
PUFAs.
The
diol/epoxide
ratios
decreased
at
days,
suggesting
that
fumonisins
did
not
induce
an
inflammatory
response.
brain,
most
discriminative
ω3-PUFAs,
including
docosahexaenoic
docosapentaenoic
LOX
pathway.
By
several
arachidonic
spanning
all
enzymatic
became
discriminative.
general,
4
then
returned
initial
levels.
Taken
together,
these
results
show
strong
are
both
specific
distinct.
Язык: Английский