Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka DOI

Kensuke Mitsunaga,

Sheikh Shohag,

C. Ming

и другие.

Aquatic Toxicology, Год журнала: 2024, Номер 273, С. 107007 - 107007

Опубликована: Июнь 21, 2024

Язык: Английский

Fabrication of a surface molecularly imprinted polymer membrane based on a single template and its application in the separation and extraction of phenytoin, phenobarbital and lamotrigine DOI Creative Commons
Yanlin Zhao,

Yu-xin You,

Yu‐lang Chen

и другие.

RSC Advances, Год журнала: 2024, Номер 14(12), С. 8353 - 8365

Опубликована: Янв. 1, 2024

A molecularly imprinted polymer membrane (MIPM) was prepared using PVDF as the support and phenytoin (PHT) a single template. The results indicated that MIPMs can be used to extract PHT, phenobarbital, lamotrigine in different matrices.

Язык: Английский

Процитировано

4
Gold nanoparticles “AuNPs” -mediated amelioration of experimentally toxic-induced cerebellar syndrome: Insights into cytomolecular and immuno-histochemical modifications, with a focus on CREB/ Tau modulation DOI
Mai A. Samak,

yara elfakharany,

Nancy Huessiny

и другие.

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102725 - 102725

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Legislative and Precautionary Approaches to Managing Pharmaceutical Contaminants in Canadian Freshwaters DOI Creative Commons

Oluwatosin Joseph Aladekoyi,

Patricia Hania,

Rania Hamza

и другие.

Water Research, Год журнала: 2025, Номер 282, С. 123714 - 123714

Опубликована: Апрель 24, 2025

Pharmaceuticals are increasingly recognized as contaminants of emerging concern in aquatic environments due to their potential ecological impacts. In Canada, pharmaceutical pollution remains an under-regulated issue within federal chemical management policy. This study critically examines the extent which Canada's Chemicals Management Plan (CMP), under Canadian Environmental Protection Act (CEPA), addresses risks posed by pharmaceuticals freshwater systems. Through a review recent legislation and scientific information, identifies regulatory gaps, including limitations current wastewater treatment practices risk assessments. The CMP sets out guidelines for assessing managing chemicals CEPA minimize toxic substances. Despite evidence toxicity ecosystems, relatively few have been assessed CMP. article explores how multi-level governments can strengthen governance, particularly light 2023 legislative amendments CEPA. Drawing on comparative insights from European Union, emphasizes need integrate expanded screening criteria, enhanced monitoring, revised persistence bioaccumulation thresholds into framework. These improvements would enable Canada adopt more adaptive precautionary approach ecosystems while contributing global efforts that advance sustainable water practices.

Язык: Английский

Процитировано

0
Determination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry after its preconcentration by simple liquid-phase microextraction DOI
Sezin Erarpat,

Gizem Nur Ayan,

Süleyman Bodur

и другие.

Environmental Monitoring and Assessment, Год журнала: 2024, Номер 196(5)

Опубликована: Апрель 15, 2024

Язык: Английский

Процитировано

2
Developmental toxicity of the emerging contaminant cyclophosphamide and the integrated biomarker response (IBRv2) in zebrafish DOI
Tamilselvan Hema, Rama-Krishnan Poopal, Mathan Ramesh

и другие.

Environmental Science Processes & Impacts, Год журнала: 2023, Номер 25(8), С. 1391 - 1406

Опубликована: Янв. 1, 2023

The safety of cyclophosphamide (CP) in the early developmental stages is not studied yet; it important to study responses at these because they might have relevance CP-administered humans. We toxicity CP by analysing physiological, morphological, and oxidative stress, neurotransmission enzymes, gene expression histological endpoints zebrafish embryos/larvae. lasted for 120 hpf environmentally relevant concentrations CP. No visible alterations were noticed control group. Delayed hatching, slow heart rate, yolk sac oedema, pericardial morphological deformities, incompetence stress biomarkers, excessive generation ROS, apoptosis, inhibition neurotransmitters histopathological anomalies observed CP-treated groups. These found be concentration- duration-dependent effects physiological endpoints, whereas concentration-dependent antioxidants, apoptosis endpoints. Biomarkers standardised using integrated biomarker response-IBRv2 index. IBRv2 index showed a behaviour. A non-lethal teratogenic effect was embryos/larvae concentrations. biomarkers are sensitive, interrelated; thus, their useful assess veiled unseen hazards pharmaceuticals.

Язык: Английский

Процитировано

5
Multi-biomarker approach to evaluate the neurotoxic effects of environmentally relevant concentrations of phenytoin on adult zebrafish Danio rerio DOI

Jesús Daniel Cardoso-Vera,

Leobardo Manuel Gómez‐Oliván, Hariz Islas‐Flores

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 834, С. 155359 - 155359

Опубликована: Апрель 20, 2022

Язык: Английский

Процитировано

7
Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug DOI

Ayaka Sawada,

Dorcas Uaciquete, Yoshifumi Horie

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 108, С. 104474 - 104474

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

1
Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka DOI

Kensuke Mitsunaga,

Sheikh Shohag,

C. Ming

и другие.

Aquatic Toxicology, Год журнала: 2024, Номер 273, С. 107007 - 107007

Опубликована: Июнь 21, 2024

Язык: Английский

Процитировано

1