Fabrication of a surface molecularly imprinted polymer membrane based on a single template and its application in the separation and extraction of phenytoin, phenobarbital and lamotrigine

RSC Advances, Journal Year: 2024, Volume and Issue: 14(12), P. 8353 - 8365

Published: Jan. 1, 2024

A molecularly imprinted polymer membrane (MIPM) was prepared using PVDF as the support and phenytoin (PHT) a single template. The results indicated that MIPMs can be used to extract PHT, phenobarbital, lamotrigine in different matrices.

Language: Английский

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Gold nanoparticles “AuNPs” -mediated amelioration of experimentally toxic-induced cerebellar syndrome: Insights into cytomolecular and immuno-histochemical modifications, with a focus on CREB/ Tau modulation

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102725 - 102725

Published: Jan. 11, 2025

Language: Английский

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Legislative and Precautionary Approaches to Managing Pharmaceutical Contaminants in Canadian Freshwaters

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123714 - 123714

Published: April 1, 2025

Language: Английский

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Determination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry after its preconcentration by simple liquid-phase microextraction

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(5)

Published: April 15, 2024

Language: Английский

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Developmental toxicity of the emerging contaminant cyclophosphamide and the integrated biomarker response (IBRv2) in zebrafish

Environmental Science Processes & Impacts, Journal Year: 2023, Volume and Issue: 25(8), P. 1391 - 1406

Published: Jan. 1, 2023

The safety of cyclophosphamide (CP) in the early developmental stages is not studied yet; it important to study responses at these because they might have relevance CP-administered humans. We toxicity CP by analysing physiological, morphological, and oxidative stress, neurotransmission enzymes, gene expression histological endpoints zebrafish embryos/larvae. lasted for 120 hpf environmentally relevant concentrations CP. No visible alterations were noticed control group. Delayed hatching, slow heart rate, yolk sac oedema, pericardial morphological deformities, incompetence stress biomarkers, excessive generation ROS, apoptosis, inhibition neurotransmitters histopathological anomalies observed CP-treated groups. These found be concentration- duration-dependent effects physiological endpoints, whereas concentration-dependent antioxidants, apoptosis endpoints. Biomarkers standardised using integrated biomarker response-IBRv2 index. IBRv2 index showed a behaviour. A non-lethal teratogenic effect was embryos/larvae concentrations. biomarkers are sensitive, interrelated; thus, their useful assess veiled unseen hazards pharmaceuticals.

Language: Английский

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Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 273, P. 107007 - 107007

Published: June 21, 2024

Language: Английский

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Multi-biomarker approach to evaluate the neurotoxic effects of environmentally relevant concentrations of phenytoin on adult zebrafish Danio rerio

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 834, P. 155359 - 155359

Published: April 20, 2022

Language: Английский

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Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104474 - 104474

Published: May 17, 2024

Language: Английский

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