De Novo Assembly and Annotation of the Pantranscriptome of Astyanax Lacustris on the Liver and Pituitary-Gonadal Axis
Опубликована: Янв. 1, 2025
Язык: Английский
Multi-biomarker approach to assess the toxicity of carbamazepine, a neuropharmaceutical, in the female fish Astyanax lacustris (Teleostei: Characidae)
Environmental Toxicology and Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 104653 - 104653
Опубликована: Фев. 1, 2025
Язык: Английский
De novo assembly and annotation of the pantranscriptome of Astyanax lacustris on the liver and pituitary-gonadal axis
Marine Genomics,
Год журнала:
2025,
Номер
81, С. 101190 - 101190
Опубликована: Апрель 16, 2025
Язык: Английский
Delayed diagnosis of the full triad autoimmune polyendocrine syndrome type 2 with adrenal crisis: a case report and literature review
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 9, 2025
Background
Autoimmune
polyendocrine
syndrome
type
2
(APS-2)
is
a
rare
disorder
characterized
by
autoimmune
damage
to
multiple
endocrine
glands
and
typically
involves
primary
adrenal
insufficiency
(PAI),
thyroid
disease
(AITD),
1
diabetes
mellitus
(T1DM).
Clinical
presentations
that
feature
the
full
triad
alongside
crisis
(AC)
are
rare,
with
only
four
such
cases
reported
globally.
While
AC
most
life-threatening
acute
complication
of
APS-2,
its
pathogenesis
complex
incompletely
understood.
there
potential
triggers,
role
exogenous
substances
as
traditional
Chinese
medicine
[TCM]
has
not
been
systematically
examined.
Case
presentation
A
69-year-old
female
was
hospitalized
9-year
history
increasing
fatigue,
which
had
recently
worsened
due
high
fever,
anorexia,
vomiting
lasting
days.
She
previously
diagnosed
T1DM
(nine
years
prior)
AITD
(five
prior).
Four
earlier,
she
underwent
thymoma
resection.
Three
before
admission,
self-administered
an
unknown
TCM
remedy
coincided
increased
fatigue
mucocutaneous
hyperpigmentation.
On
in
hypovolemic
shock
severe
hyponatremia
(118.0
mmol/L).
Laboratory
tests
revealed
low
basal
cortisol
(2.38
μg/dL)
markedly
elevated
adrenocorticotropic
hormone
(>1250
pg/mL).
An
stimulation
test
confirmed
non-responsive
function,
indicating
PAI.
Together
her
medical
positive
antibody
profile,
APS-2
diagnosed.
responded
well
high-dose
intravenous
glucocorticoid
therapy,
sodium
supplementation,
symptomatic
management.
Although
persistent
recurred
following
discharge,
it
resolved
fludrocortisone
acetate
condition
remained
stable
at
last
follow-up.
Conclusion
We
report
fifth
case
full-triad
document
diagnostic
delay
non-specific
symptoms
asynchronous
multi-glandular
involvement.
Thyroxine
replacement
therapy
TCM-induced
changes
may
have
aggravated
metabolism
immune
imbalances,
hastening
failure.
Clinicians
should
implement
stepwise
organ-function
monitoring
patients
any
single-gland
disease,
maintain
vigilance
for
medication
use,
multidisciplinary
management
strategies
mitigate
risk
AC.
This
provides
critical
insights
into
both
clinical
APS-2.
Язык: Английский
A comprehensive review on the adsorptive removal of pharmaceutical pollutants: Occurrence, toxicology, molecular simulation and mechanistic insights
Talanta Open,
Год журнала:
2025,
Номер
unknown, С. 100491 - 100491
Опубликована: Май 1, 2025
Язык: Английский
Photocatalytic performance with electrochemical effects for ZnO/Graphene Quantum Dots/CdSe nanocomposite toward ciprofloxacin antibiotics and paracetamol degradation under visible light
Materials Today Chemistry,
Год журнала:
2024,
Номер
42, С. 102393 - 102393
Опубликована: Ноя. 10, 2024
Язык: Английский
Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio)
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116976 - 116976
Опубликована: Авг. 30, 2024
The
accumulation
of
the
active
pharmaceutical
chemical
in
environment
usually
results
environmental
pollution
to
increase
risk
human
health.
Indomethacin
is
a
non-steroidal
anti-inflammatory
drug
that
potentially
causes
systemic
and
developmental
toxicity
various
tissues.
However,
there
have
been
few
studies
for
its
potential
effects
on
cardiac
development.
In
this
study,
we
systematically
determined
cardiotoxicity
acute
indomethacin
exposure
zebrafish
at
different
concentrations
with
morphological,
histological,
molecular
levels.
Specifically,
malformation
dysfunction
development,
including
pericardial
oedema,
abnormal
heart
rate,
larger
distance
between
venous
sinus
bulbus
arteriosus
(SV-BA),
enlargement
area,
aberrant
motor
capability,
were
after
exposure.
addition,
further
investigation
indicated
myocardial
apoptosis
dose-dependent
manner
early
stage.
Mechanistically,
our
revealed
mainly
regulates
key
development-related
genes,
especially
genes
related
muscle
contraction-related
signaling
pathway,
embryos.
Thus,
findings
suggested
might
cause
by
disturbing
pathway
inducing
Язык: Английский