Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio) DOI Creative Commons

Yi Liu,

Xiaoling Shi,

Chunjiao Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116976 - 116976

Published: Aug. 30, 2024

The accumulation of the active pharmaceutical chemical in environment usually results environmental pollution to increase risk human health. Indomethacin is a non-steroidal anti-inflammatory drug that potentially causes systemic and developmental toxicity various tissues. However, there have been few studies for its potential effects on cardiac development. In this study, we systematically determined cardiotoxicity acute indomethacin exposure zebrafish at different concentrations with morphological, histological, molecular levels. Specifically, malformation dysfunction development, including pericardial oedema, abnormal heart rate, larger distance between venous sinus bulbus arteriosus (SV-BA), enlargement area, aberrant motor capability, were after exposure. addition, further investigation indicated myocardial apoptosis dose-dependent manner early stage. Mechanistically, our revealed mainly regulates key development-related genes, especially genes related muscle contraction-related signaling pathway, embryos. Thus, findings suggested might cause by disturbing pathway inducing

Language: Английский

De Novo Assembly and Annotation of the Pantranscriptome of Astyanax Lacustris on the Liver and Pituitary-Gonadal Axis DOI
David Aciole Barbosa, Giovana Souza Branco, Aline D. Gomes

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-biomarker approach to assess the toxicity of carbamazepine, a neuropharmaceutical, in the female fish Astyanax lacustris (Teleostei: Characidae) DOI
Amanda da Silveira Guerreiro,

G. Aguiar,

Cecília Bertacini de Assis

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653

Published: Feb. 1, 2025

Language: Английский

Citations

0
De novo assembly and annotation of the pantranscriptome of Astyanax lacustris on the liver and pituitary-gonadal axis DOI
David Aciole Barbosa, Giovana Souza Branco, Aline D. Gomes

et al.

Marine Genomics, Journal Year: 2025, Volume and Issue: 81, P. 101190 - 101190

Published: April 16, 2025

Language: Английский

Citations

0
Delayed diagnosis of the full triad autoimmune polyendocrine syndrome type 2 with adrenal crisis: a case report and literature review DOI Creative Commons
Zhiwen Yao, Danlin Xu,

Xiao-Kai Hu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Background Autoimmune polyendocrine syndrome type 2 (APS-2) is a rare disorder characterized by autoimmune damage to multiple endocrine glands and typically involves primary adrenal insufficiency (PAI), thyroid disease (AITD), 1 diabetes mellitus (T1DM). Clinical presentations that feature the full triad alongside crisis (AC) are rare, with only four such cases reported globally. While AC most life-threatening acute complication of APS-2, its pathogenesis complex incompletely understood. there potential triggers, role exogenous substances as traditional Chinese medicine [TCM] has not been systematically examined. Case presentation A 69-year-old female was hospitalized 9-year history increasing fatigue, which had recently worsened due high fever, anorexia, vomiting lasting days. She previously diagnosed T1DM (nine years prior) AITD (five prior). Four earlier, she underwent thymoma resection. Three before admission, self-administered an unknown TCM remedy coincided increased fatigue mucocutaneous hyperpigmentation. On in hypovolemic shock severe hyponatremia (118.0 mmol/L). Laboratory tests revealed low basal cortisol (2.38 μg/dL) markedly elevated adrenocorticotropic hormone (>1250 pg/mL). An stimulation test confirmed non-responsive function, indicating PAI. Together her medical positive antibody profile, APS-2 diagnosed. responded well high-dose intravenous glucocorticoid therapy, sodium supplementation, symptomatic management. Although persistent recurred following discharge, it resolved fludrocortisone acetate condition remained stable at last follow-up. Conclusion We report fifth case full-triad document diagnostic delay non-specific symptoms asynchronous multi-glandular involvement. Thyroxine replacement therapy TCM-induced changes may have aggravated metabolism immune imbalances, hastening failure. Clinicians should implement stepwise organ-function monitoring patients any single-gland disease, maintain vigilance for medication use, multidisciplinary management strategies mitigate risk AC. This provides critical insights into both clinical APS-2.

Language: Английский

Citations

0
Photocatalytic performance with electrochemical effects for ZnO/Graphene Quantum Dots/CdSe nanocomposite toward ciprofloxacin antibiotics and paracetamol degradation under visible light DOI
David Nugroho,

Latiful Kabir,

Young Jun Joo

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 42, P. 102393 - 102393

Published: Nov. 10, 2024

Language: Английский

Citations

3
Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio) DOI Creative Commons

Yi Liu,

Xiaoling Shi,

Chunjiao Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116976 - 116976

Published: Aug. 30, 2024

The accumulation of the active pharmaceutical chemical in environment usually results environmental pollution to increase risk human health. Indomethacin is a non-steroidal anti-inflammatory drug that potentially causes systemic and developmental toxicity various tissues. However, there have been few studies for its potential effects on cardiac development. In this study, we systematically determined cardiotoxicity acute indomethacin exposure zebrafish at different concentrations with morphological, histological, molecular levels. Specifically, malformation dysfunction development, including pericardial oedema, abnormal heart rate, larger distance between venous sinus bulbus arteriosus (SV-BA), enlargement area, aberrant motor capability, were after exposure. addition, further investigation indicated myocardial apoptosis dose-dependent manner early stage. Mechanistically, our revealed mainly regulates key development-related genes, especially genes related muscle contraction-related signaling pathway, embryos. Thus, findings suggested might cause by disturbing pathway inducing

Language: Английский

Citations

1