Deleted Journal,
Год журнала:
2023,
Номер
2, С. 262 - 262
Опубликована: Дек. 30, 2023
Heart
failure
(HF)
after
a
myocardial
infarction
(MI)
is
one
of
the
most
frequent
complications
and
with
highest
mortality
rate
in
population.
Given
this,
importance
finding
appropriate
biomarkers
for
diagnosis,
prognosis
treatment
this
condition.
The
review
was
carried
out
under
an
analytical
approach,
using
PRISMA
statement
as
methodology;
documents
were
retrieved
through
Scopus,
ScienceDirect
PubMed
databases,
where
20
articles
that
met
certain
inclusion
criteria
recognized.
In
conclusion,
it
explained
use
standard
such
B-type
natriuretic
peptide
(BNP)
non-terminal
pro-BNP
clinical
practice
have
limitations,
especially
due
to
their
low
specificity
HF
post-MI
complication.
Therefore,
currently,
reflect
alteration
cardiac
integrity,
injury
necrosis,
inflammatory
biomarkers,
fibrosis,
biomechanical
stress,
other
types
non-coding
RNAs
are
being
investigated
Frontiers in Cardiovascular Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Окт. 30, 2023
Myocardial
infarction
(MI)
is
a
prevalent
cardiovascular
disease
characterized
by
myocardial
necrosis
resulting
from
coronary
artery
ischemia
and
hypoxia,
which
can
lead
to
severe
complications
such
as
arrhythmia,
cardiac
rupture,
heart
failure,
sudden
death.
Despite
being
research
hotspot,
the
etiological
mechanism
of
MI
remains
unclear.
The
emergence
widespread
use
omics
technologies,
including
genomics,
transcriptomics,
proteomics,
metabolomics,
other
omics,
have
provided
new
opportunities
for
exploring
molecular
identifying
large
number
biomarkers.
However,
single-omics
approach
has
limitations
in
understanding
complex
biological
pathways
diseases.
multi-omics
reveal
interaction
network
among
molecules
at
various
levels
overcome
approaches.
This
review
focuses
on
studies
MI,
epigenomics,
omics.
exploration
extended
into
domain
integrative
analysis,
accompanied
compilation
diverse
online
resources,
databases,
tools
conducive
these
investigations.
Additionally,
we
discussed
role
prospects
approaches
personalized
medicine,
highlighting
potential
improving
diagnosis,
treatment,
prognosis
MI.
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(3), С. 831 - 852
Опубликована: Март 31, 2024
Non-coding
RNAs
(ncRNAs)
are
a
diverse
group
of
functional
RNA
molecules
that
lack
the
ability
to
code
for
proteins.
Despite
missing
this
traditional
role,
ncRNAs
have
emerged
as
crucial
regulators
various
biological
processes
and
been
implicated
in
development
progression
many
diseases,
including
cancer.
MicroRNAs
(miRNAs)
long
non-coding
(lncRNAs)
two
prominent
classes
key
players
cancer
pathophysiology.
In
particular,
miR-21
has
reported
exhibit
oncogenic
roles
forms
human
cancer,
prostate,
breast,
lung,
colorectal
context,
overexpression
is
closely
associated
with
tumor
proliferation,
growth,
invasion,
angiogenesis,
chemoresistance,
whereas
inactivation
linked
regression
most
tumor-related
processes.
Accordingly,
modulator
canonical
pathways
such
PTEN/PI3K/Akt,
Wnt/β-catenin,
STAT,
p53,
MMP2,
MMP9.
Moreover,
interplays
between
lncRNA
miRNA
further
complicate
regulatory
mechanisms
underlying
progression.
regard,
several
lncRNAs
found
interact
and,
by
functioning
competitive
endogenous
(ceRNAs)
or
sponges,
can
modulate
tumorigenesis.
This
work
presents
discusses
recent
findings
highlighting
pathophysiological
implications
miR-21-lncRNA
axis
occurrence,
development,
The
data
collected
indicate
specific
lncRNAs,
MEG3,
CASC2,
GAS5,
strongly
types
gastric,
cervical,
glioma.
Indeed,
these
well-known
suppressors
commonly
downregulated
different
tumors.
Conversely,
modulating
signaling
pathways,
their
preventing
formation
development.
review
highlights
significance
potential
use
therapy
diagnostic
prognostic
markers.
Functional & Integrative Genomics,
Год журнала:
2023,
Номер
23(2)
Опубликована: Май 27, 2023
Circular
RNAs
(circRNAs)
are
regulatory
elements
that
involved
in
orchestrating
gene
expression
and
protein
functions
implicated
various
biological
processes
including
cancer.
Notably,
breast
cancer
has
a
significant
mortality
rate
is
one
of
the
most
common
malignancies
women.
CircRNAs
have
been
demonstrated
to
contribute
pathogenesis
its
initiation,
progression,
metastasis,
resistance
drugs.
By
acting
as
miRNA
sponges,
circRNAs
can
indirectly
influence
by
disrupting
regulation
their
target
genes,
ultimately
altering
course
development
progression.
Additionally,
interact
with
proteins
modulate
signaling
pathways
initiation
Recently,
encode
peptides
play
role
pathophysiology
other
diseases
potential
diagnostic
biomarkers
therapeutic
targets
for
cancers
possess
differentiate,
such
stability,
specificity,
sensitivity,
be
detected
several
specimens
blood,
saliva,
urine.
Moreover,
an
important
cellular
cell
proliferation,
differentiation,
apoptosis,
all
which
integral
factors
progression
This
review
synthesizes
cancer,
scrutinizing
contributions
onset
evolution
disease
through
interactions
exosomes
cancer-related
intracellular
pathways.
It
also
delves
into
use
circRNA
biomarker
against
discusses
databases
online
tools
offer
crucial
information
networks.
Lastly,
challenges
prospects
utilizing
clinical
settings
associated
explored.
Journal of Molecular and Cellular Cardiology Plus,
Год журнала:
2025,
Номер
11, С. 100284 - 100284
Опубликована: Янв. 18, 2025
Cardiogenic
shock
(CS)
is
a
medical
emergency
with
high
in-hospital
mortality.
New
biomarkers
are
needed
to
identify
patients
at
greater
risk
of
adverse
outcomes.
This
study
aimed
investigate
the
prognostic
potential
microRNAs
(miRNAs)
in
assessment
outcome
cardiogenic
shock.
Circulating
miRNA
levels
were
measured
by
quantitative
PCR
plasma
samples
collected
baseline
from
165
multicenter,
prospective,
observational
CardShock
and
compared
between
90-day
survivors
non-survivors.
Of
10
studied
miRNAs,
median
miR-20b-5p
significantly
higher
non-survivors
[median
0.014
arbitrary
units
(AU)
(interquartile
range
(IQR)
0.003-0.024)
vs.
0.008
AU
(IQR
0.001-0.015),
p
=
0.013]
[0.015
0.003-0.025)
0.010
0.012],
respectively.
In
Cox
regression
analysis,
highest
quartile
associated
survival
(adjusted
hazard
ratio
2.47
(95
%
confidence
interval
1.16-5.28),
0.019)
when
adjusted
for
Risk
Score
variables
(age,
confusion
presentation,
previous
myocardial
infarction
or
coronary
artery
bypass
grafting,
acute
syndrome
(ACS)
etiology,
left
ventricular
ejection
fraction,
lactate,
estimated
glomerular
filtration
rate).
A
similar
association
was
also
confirmed
ACS
patient
subcohort
(79
CS
patients).
The
results
this
indicate
that
circulating
could
help
assessing
patients.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1747 - 1768
Опубликована: Фев. 1, 2025
Abstract:
Myocardial
infarction
(MI)
is
the
leading
cause
of
mortality
from
cardiovascular
diseases.
Rapid
diagnosis
and
effective
treatment
are
critical
for
improving
patient
prognosis.
Although
current
diagnostic
therapeutic
approaches
have
made
significant
progress,
they
still
face
challenges
such
as
ischemia-reperfusion
injury,
microcirculatory
disorders,
adverse
cardiac
remodeling,
inflammatory
responses.
These
issues
highlight
urgent
need
innovative
solutions.
Nanomaterials,
with
their
diverse
types,
excellent
physicochemical
properties,
biocompatibility,
targeting
capabilities,
offer
promising
potential
in
addressing
these
challenges.
Advances
nanotechnology
increasingly
drawn
attention
to
application
nanomaterials
both
diagnosing
treating
myocardial
infarction.
We
summarize
pathophysiological
mechanisms
staging
systematically
review
applications
MI
diagnosis,
including
detection
biomarkers
imaging
techniques,
well
treatment,
encompassing
anti-inflammatory
effects,
antioxidant
stress,
inhibition
fibrosis,
promotion
angiogenesis,
conduction
repair.
analyze
existing
provide
insights
into
future
research
directions
Specifically,
we
discuss
rigorous
safety
assessments,
long-term
efficacy
studies,
development
robust
strategies
translating
laboratory
findings
clinical
practice.
In
conclusion,
holds
promise
a
new
strategy
Its
enhance
outcomes
revolutionize
care
makes
it
an
exciting
area
practical
real-world
settings.
Keywords:
infarction,
nanomaterials,
nanoparticles,
Biochemical Pharmacology,
Год журнала:
2023,
Номер
215, С. 115732 - 115732
Опубликована: Авг. 2, 2023
An
intricate
interplay
between
genetic
and
environmental
factors
contributes
to
the
development
of
type
2
diabetes
(T2D)
its
complications.
Therefore,
it
is
not
surprising
that
epigenome
also
plays
a
crucial
role
in
pathogenesis
T2D.
Hyperglycemia
can
indeed
trigger
epigenetic
modifications,
thereby
regulating
different
gene
expression
patterns.
Such
changes
persist
after
normalizing
serum
glucose
concentrations,
suggesting
presence
'metabolic
memory'
previous
hyperglycemia
which
may
be
epigenetically
regulated.
Metformin,
derivative
biguanide
known
reduce
concentrations
patients
with
T2D,
appears
exert
additional
pleiotropic
effects
are
mediated
by
multiple
modifications.
modifications
have
been
reported
various
organs,
tissues,
cellular
compartments
appear
account
for
metformin
on
glycemic
control
as
well
local
systemic
inflammation,
oxidant
stress,
fibrosis.
This
review
discusses
emerging
evidence
regarding
metformin-mediated
particularly
short
long
non-coding
RNAs,
DNA
methylation,
histone
proteins
post-translational
their
biological
clinical
significance,
potential
therapeutic
applications,
future
research
directions.
