Elements of cancer immunity and the cancer–immune set point

Nature, Год журнала: 2017, Номер 541(7637), С. 321 - 330

Опубликована: Янв. 1, 2017

Язык: Английский

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Tumour-associated macrophages as treatment targets in oncology

Nature Reviews Clinical Oncology, Год журнала: 2017, Номер 14(7), С. 399 - 416

Опубликована: Янв. 24, 2017

Язык: Английский

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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Nature Reviews Drug Discovery, Год журнала: 2019, Номер 18(3), С. 197 - 218

Опубликована: Янв. 4, 2019

Язык: Английский

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Immunogenic cell death in cancer and infectious disease

Nature reviews. Immunology, Год журнала: 2016, Номер 17(2), С. 97 - 111

Опубликована: Окт. 17, 2016

Язык: Английский

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Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Nature reviews. Cancer, Год журнала: 2016, Номер 16(5), С. 275 - 287

Опубликована: Апрель 15, 2016

Язык: Английский

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The immune contexture in cancer prognosis and treatment

Nature Reviews Clinical Oncology, Год журнала: 2017, Номер 14(12), С. 717 - 734

Опубликована: Июль 25, 2017

Язык: Английский

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Tertiary lymphoid structures in the era of cancer immunotherapy

Nature reviews. Cancer, Год журнала: 2019, Номер 19(6), С. 307 - 325

Опубликована: Май 15, 2019

Язык: Английский

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Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study

The Lancet Oncology, Год журнала: 2016, Номер 17(11), С. 1497 - 1508

Опубликована: Окт. 12, 2016

Язык: Английский

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Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

Nature Reviews Clinical Oncology, Год журнала: 2019, Номер 16(6), С. 356 - 371

Опубликована: Янв. 31, 2019

Язык: Английский

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Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Genome Medicine, Год журнала: 2019, Номер 11(1)

Опубликована: Май 24, 2019

We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, immunohistochemistry data.quanTIseq analysis 8000 revealed that cytotoxic T infiltration is more strongly associated with activation CXCR3/CXCL9 axis than mutational load deconvolution-based scores have prognostic value several solid cancers. Finally, we used show how kinase inhibitors modulate contexture reveal immune-cell underlie differential patients' responses checkpoint blockers.Availability: available at http://icbi.at/quantiseq .

Язык: Английский

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