Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 26, 2024
Abstract
The
tumor
microenvironment
(TME)
constitutes
a
complex
comprising
diverse
array
of
immune
cells
and
stromal
components.
Within
this
intricate
context,
tumor-associated
macrophages
(TAMs)
exhibit
notable
spatial
heterogeneity.
This
heterogeneity
contributes
to
various
facets
behavior,
including
response
modulation,
angiogenesis,
tissue
remodeling,
metastatic
potential.
review
summarizes
the
distribution
in
both
physiological
environment
TME.
Moreover,
paper
explores
interactions
between
TAMs
cell
populations
(T
cells,
dendritic
neutrophils,
natural
killer
other
cells)
within
These
bidirectional
exchanges
form
network
that
influence
surveillance
evasion
strategies.
Investigating
TAM
its
with
different
offers
potential
avenues
for
therapeutic
interventions.
Additionally,
discusses
strategies
targeting
macrophages,
aiming
uncover
novel
approaches
immunotherapy.
Immunity,
Год журнала:
2023,
Номер
56(10), С. 2188 - 2205
Опубликована: Окт. 1, 2023
The
cancer-immunity
cycle
provides
a
framework
to
understand
the
series
of
events
that
generate
anti-cancer
immune
responses.
It
emphasizes
iterative
nature
response
where
killing
tumor
cells
by
T
initiates
subsequent
rounds
antigen
presentation
and
cell
stimulation,
maintaining
active
immunity
adapting
it
evolution.
Any
step
can
become
rate-limiting,
rendering
system
unable
control
growth.
Here,
we
update
based
on
remarkable
progress
past
decade.
Understanding
mechanism
checkpoint
inhibition
has
evolved,
as
our
view
dendritic
in
sustaining
anti-tumor
immunity.
We
additionally
account
for
role
microenvironment
facilitating,
not
just
suppressing,
response,
discuss
importance
considering
tumor's
immunological
phenotype,
"immunotype".
While
these
new
insights
add
some
complexity
cycle,
they
also
provide
targets
research
therapeutic
intervention.
Cellular and Molecular Immunology,
Год журнала:
2023,
Номер
20(9), С. 983 - 992
Опубликована: Июль 10, 2023
Abstract
Macrophages
are
critical
regulators
of
tissue
homeostasis
but
also
abundant
in
the
tumor
microenvironment
(TME).
In
both
primary
tumors
and
metastases,
such
tumor-associated
macrophages
(TAMs)
seem
to
support
development.
While
we
know
that
TAMs
dominant
immune
cells
TME,
their
vast
heterogeneity
associated
functions
only
just
being
unraveled.
this
review,
outline
various
known
TAM
populations
found
thus
far
delineate
specialized
roles
with
main
stages
cancer
progression.
We
discuss
how
may
prime
premetastatic
niche
enable
growth
a
metastasis
then
subsequent
metastasis-associated
can
secondary
growth.
Finally,
speculate
on
challenges
remain
be
overcome
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 19, 2023
As
one
of
the
four
major
means
cancer
treatment
including
surgery,
radiotherapy
(RT),
chemotherapy,
immunotherapy,
RT
can
be
applied
to
various
cancers
as
both
a
radical
and
an
adjuvant
before
or
after
surgery.
Although
is
important
modality
for
treatment,
consequential
changes
caused
by
in
tumor
microenvironment
(TME)
have
not
yet
been
fully
elucidated.
RT-induced
damage
cells
leads
different
outcomes,
such
survival,
senescence,
death.
During
RT,
alterations
signaling
pathways
result
local
immune
microenvironment.
However,
some
are
immunosuppressive
transform
into
phenotypes
under
specific
conditions,
leading
development
radioresistance.
Patients
who
radioresistant
respond
poorly
may
experience
progression.
Given
that
emergence
radioresistance
inevitable,
new
radiosensitization
treatments
urgently
needed.
In
this
review,
we
discuss
irradiated
TME
regimens
describe
existing
potential
molecules
could
targeted
improve
therapeutic
effects
RT.
Overall,
review
highlights
possibilities
synergistic
therapy
building
on
research.
