Cancer Letters, Год журнала: 2025, Номер unknown, С. 217613 - 217613
Опубликована: Март 1, 2025
Язык: Английский
Immunity, Год журнала: 2023, Номер 56(10), С. 2188 - 2205
Опубликована: Окт. 1, 2023
The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.
Язык: Английский
Процитировано
351
Smart Medicine, Год журнала: 2024, Номер 3(1)
Опубликована: Фев. 1, 2024
Abstract Immune engineering, a burgeoning field within regenerative medicine, involves spectrum of strategies to optimize the intricate interplay between tissue biomaterials and host tissue. These are applied across different types various disease models, which encompasses finely modulating immune response at levels cells factors, aiming mitigate adverse effects like fibrosis persistent inflammation that may arise injury site consequently promote regeneration. With continuous progress in electrospinning technology, immunoregulatory capabilities electrospun fibers have gained substantial attention over years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, reliable pharmaceutical compound capacity, emerged as key players among engineering materials. This review specifically focuses on role fiber‐based emphasizing unique design strategies. Notably, actively engages by responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, (iv) biological grafting. presents comprehensive overview mechanisms system injured tissues while unveiling adopted orchestrate regulation. Furthermore, explores current developmental trends limitations concerning function drive advancements its full potential.
Язык: Английский
Процитировано
62
Cell, Год журнала: 2024, Номер 187(9), С. 2052 - 2078
Опубликована: Апрель 1, 2024
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense respond with targeted precision to perturbations induced pathogens tissue damage. Here, we review key principles underlying adaptive orchestrated distinct T cell B populations their extensions disease therapies. We discuss the intracellular intercellular processes shaping antigen specificity recognition in immune activation lymphocyte functions mediating effector memory responses. also describe how balance protective autoimmunity immunopathology, including during tolerance, response chronic stimulation, adaptation non-lymphoid tissues coordinating homeostasis. Finally, extracellular signals cell-intrinsic programs underpinning conclude summarizing advances vaccination engineering responses for therapeutic interventions. A deeper understanding of these holds promise uncovering new means improve human health.
Язык: Английский
Процитировано
62
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Янв. 31, 2024
The liver is essential for metabolic homeostasis. onset of cancer often accompanied by dysregulated function, leading to rearrangements. Overwhelming evidence has illustrated that cellular metabolism can, in turn, promote anabolic growth and tumor propagation a hostile microenvironment. In addition supporting continuous survival, disrupted process also creates obstacles the anticancer immune response restrains durable clinical remission following immunotherapy. this review, we elucidate communication between cells their surrounding discuss how reprogramming impacts microenvironment efficacy We describe crucial role gut-liver axis remodeling crosstalk surveillance escape, highlighting novel therapeutic opportunities.
Язык: Английский
Процитировано
40
Advanced Science, Год журнала: 2024, Номер 11(13)
Опубликована: Янв. 25, 2024
Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based
Язык: Английский
Процитировано
39
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Окт. 18, 2024
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.
Язык: Английский
Процитировано
35
The Journal of Experimental Medicine, Год журнала: 2024, Номер 221(3)
Опубликована: Фев. 27, 2024
T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer. Upon immune challenge, exit from a quiescent state, followed by clonal expansion effector differentiation. These processes shaped three established signals, namely antigen stimulation (Signal 1), costimulation 2), cytokines 3). Emerging findings reveal that nutrients, including glucose, amino acids, lipids, crucial regulators of cell responses interplay with Signals 1-3, highlighting nutrients as Signal 4 license immunity. Here, we first summarize the functional importance underlying mechanisms nutrient transport, sensing, signaling orchestrating activation quiescence exit. We also discuss roles programming differentiation fitness how can be targeted improve disease therapy. Understanding respond microenvironments will provide insights into context-dependent functions therapeutic interventions.
Язык: Английский
Процитировано
26
Nature Immunology, Год журнала: 2024, Номер 25(11), С. 2140 - 2151
Опубликована: Окт. 7, 2024
Язык: Английский
Процитировано
24
Trends in Immunology, Год журнала: 2024, Номер 45(4), С. 303 - 313
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
20
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 29, 2024
Abstract The immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8 + T cells play crucial role opposing pathological threats. Various immunotherapies based on have emerged recent decades, showing their promising results treating intractable diseases. However, the fight constantly changing evolving cancers, formation function of can be challenged by tumors that might train group accomplices to resist cell killing. As cancer therapy stepped into era immunotherapy, understanding physiological cells, studying machinery tumor escape, thereby formulating different therapeutic strategies become imperative missions for clinical translational researchers fulfill. After brief basics cell-based biology covered, this review delineates mechanisms escape discusses immunotherapy regimens with own advantages setbacks, embracing challenges perspectives near future.
Язык: Английский
Процитировано
19