Tissue-specific properties of type 1 dendritic cells in lung cancer: implications for immunotherapy DOI Creative Commons
Laura Rodríguez,

Roberto M. Amadio,

Giulia Maria Piperno

и другие.

Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(3), С. e010547 - e010547

Опубликована: Март 1, 2025

Checkpoint inhibitors have led to remarkable benefits in non-small cell lung cancer (NSCLC), yet response rates remain below expectations. High-dimensional analysis and mechanistic experiments clinical samples relevant NSCLC models uncovered the immune composition of tissues, providing invaluable insights into functional properties tumor-infiltrating T cells myeloid cells. Among cells, type 1 conventional dendritic (cDC1s) stand out for their unique ability induce effector CD8 against neoantigens coordinate antitumoral immunity. Notably, resident cDC1 are particularly abundant long-lived express a tissue-specific gene program, underscoring central role Here, we discuss recent on induction regulation responses cancer, separating it from tissue-agnostic knowledge generated heterogeneous tumor models. We focus most studies dissecting states spatial distribution across stages impact neoantigens. Finally, highlight gaps emerging strategies harness immunostimulatory potential.

Язык: Английский

CD8+ T cells in the cancer-immunity cycle DOI Creative Commons
Josephine R. Giles, Anna-Maria Globig,

Susan M. Kaech

и другие.

Immunity, Год журнала: 2023, Номер 56(10), С. 2231 - 2253

Опубликована: Окт. 1, 2023

Язык: Английский

Процитировано

177

Tertiary lymphoid structures and B cells: An intratumoral immunity cycle DOI Creative Commons
Wolf H. Fridman, Maxime Meylan, Guilhem Pupier

и другие.

Immunity, Год журнала: 2023, Номер 56(10), С. 2254 - 2269

Опубликована: Сен. 11, 2023

Язык: Английский

Процитировано

128

Stem-like exhausted and memory CD8+ T cells in cancer DOI
Thomas Gebhardt, Simone L. Park, Ian A. Parish

и другие.

Nature reviews. Cancer, Год журнала: 2023, Номер 23(11), С. 780 - 798

Опубликована: Окт. 11, 2023

Язык: Английский

Процитировано

78

Cancer cell-intrinsic mechanisms driving acquired immune tolerance DOI Creative Commons
Ehsan Ghorani, Charles Swanton, Sergio A. Quezada

и другие.

Immunity, Год журнала: 2023, Номер 56(10), С. 2270 - 2295

Опубликована: Окт. 1, 2023

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host immune system and evade cycle recognition destruction. Here, we review current understanding cancer cell-intrinsic factors driving evasion. We focus on T cells as key effectors anti-cancer immunity argue that destruction by gaining control over pathways usually serve maintain physiological tolerance self. Using this framework, place recent mechanistic advances in into broad categories cell localization, antigen recognition, acquisition optimal effector function. discuss redundancy involved identify knowledge gaps must be overcome better target evasion, including need for better, routinely available tools incorporate growing mechanisms stratify patients therapy trials.

Язык: Английский

Процитировано

53

Multiplex protein imaging in tumour biology DOI
Natalie de Souza, Shan Zhao, Bernd Bodenmiller

и другие.

Nature reviews. Cancer, Год журнала: 2024, Номер 24(3), С. 171 - 191

Опубликована: Фев. 5, 2024

Язык: Английский

Процитировано

34

Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates DOI Creative Commons
Candace L. Haddox, Michael J. Nathenson, Emanuele Mazzola

и другие.

Clinical Cancer Research, Год журнала: 2024, Номер 30(7), С. 1281 - 1292

Опубликована: Янв. 18, 2024

Abstract Purpose: Eribulin modulates the tumor-immune microenvironment via cGAS-STING signaling in preclinical models. This non-randomized phase II trial evaluated combination of eribulin and pembrolizumab patients with soft-tissue sarcomas (STS). Patients Methods: enrolled one three cohorts: leiomyosarcoma (LMS), liposarcomas (LPS), or other STS that may benefit from PD-1 inhibitors, including undifferentiated pleomorphic sarcoma (UPS). was administered at 1.4 mg/m2 i.v. (days 1 8) fixed-dose 200 mg (day 1) each 21-day cycle, until progression, unacceptable toxicity, completion 2 years treatment. The primary endpoint 12-week progression-free survival rate (PFS-12) cohort. Secondary endpoints included objective response rate, median PFS, safety profile, overall (OS). Pretreatment on-treatment blood specimens were who achieved durable disease control (DDC) progression within 12 weeks [early (EP)]. Multiplexed immunofluorescence performed on archival LPS samples DDC EP. Results: Fifty-seven (LMS, n = 19; LPS, 20; UPS/Other, 18). PFS-12 36.8% (90% confidence interval: 22.5–60.4) for LMS, 69.6% (54.5–89.0) 52.6% (36.8–75.3) UPS/Other cohorts. All 3 cohort angiosarcoma RECIST responses. Toxicity manageable. Higher IFNα IL4 serum levels associated clinical benefit. Immune aggregates expressing PD-L1 observed a patient completed Conclusions: demonstrated promising activity angiosarcoma.

Язык: Английский

Процитировано

20

Unveiling the impact of tertiary lymphoid structures on immunotherapeutic responses of clear cell renal cell carcinoma DOI Creative Commons
Wenhao Xu, Jiahe Lu, Xi Tian

и другие.

MedComm, Год журнала: 2024, Номер 5(1)

Опубликована: Янв. 1, 2024

Abstract Tertiary lymphoid structures (TLS) are organized aggregates of immune cells that form under pathological conditions. However, the predictive value TLS in clear cell renal carcinoma (ccRCC) for immunotherapies remains unclear. We comprehensively assessed implications prognosis and immunological responses spatial maturation heterogeneity 655 ccRCC patients. A higher proportion early‐TLS was found peritumoral TLS, while intratumoral mainly comprised secondary follicle‐like (SFL‐TLS), indicating markedly better survival. Notably, presence especially SFL‐TLS, significantly correlated with survival objective reflection rate patients receiving anti‐Programmed Cell Death Protein‐1 (PD‐1)/Programmed Death‐Ligand‐1 (PD‐L1) immunotherapies. In cluster, primary tumor‐associated macrophages, Treg infiltration regions increased prominently, suggesting an immunosuppressive tumor microenvironment. Interestingly, transcriptome annotation multispectral fluorescence showed abundance mature plasma within has capacity to produce IgA IgG, which demonstrate response rates a superior subjected immunotherapy. conclusion, this study revealed on status clinical responses, allowing improvement precise ccRCC.

Язык: Английский

Процитировано

18

Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer DOI Creative Commons
Lucas Onder, Chrysa Papadopoulou, Almut Lütge

и другие.

Cell, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

18

SCIMAP: A Python Toolkit for Integrated Spatial Analysis of Multiplexed Imaging Data DOI Creative Commons
Ajit J. Nirmal, Peter K. Sorger

The Journal of Open Source Software, Год журнала: 2024, Номер 9(97), С. 6604 - 6604

Опубликована: Май 29, 2024

Multiplexed imaging data are revolutionizing our understanding of the composition and organization tissues tumors ("Catching up with Tissue Imaging," 2022).A critical aspect such "tissue profiling" is quantifying spatial relationships among cells at different scales from interaction neighboring to recurrent communities multiple types.This often involves statistical analysis 10 7 or more in which 100 biomolecules (commonly proteins) have been measured.While software tools currently cater transcriptomics (Liu et al., 2022), there remains a need for toolkits explicitly tailored complexities multiplexed including seamlessly integrate image visualization exploration.We introduce SCIMAP, Python package specifically crafted address these challenges.With users can efficiently preprocess, analyze, visualize large datasets, facilitating exploration their significance.SCIMAP's modular design enables integration new algorithms, enhancing its capabilities analysis.

Язык: Английский

Процитировано

10

Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures DOI
Zhonghui Tang, Yinqi Bai, Qi Fang

и другие.

Cancer Cell, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

2