The success of the tumor immunotherapy: neutrophils from bench to beside

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

The present immune therapy was focused on the checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate innate system antitumor still lags out. Neutrophils are most abundant circulating leukocytes in human, and heterogeneous neutrophils have been increasingly recognized as important players tumor progression. They play double “edge-sward” by either supporting suppressing growth, including driving angiogenesis, extracellular matrix remodeling promote participating adaptive immunity, killing cells directly inhibit growth. complex role of various tumors depends microenvironment (TME) they located, emerging evidence has suggested that may determine success immunotherapy context blockade, training, drug-loaded microvesicles therapy, which makes them become an exciting target for immunotherapy, with challenges. Here, we summarize latest insights immunity discuss advances neutrophil-targeted strategies.

Язык: Английский

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Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers

Endocrine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

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Paeoniflorin Attenuates APAP-Induced Liver Injury via Intervening the Crosstalk Between Hepatocyte Pyroptosis and NETs

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1493 - 1493

Опубликована: Фев. 11, 2025

(1) Liver injury caused by an overdose of acetaminophen (APAP) represents a major public health concern. Paeoniflorin (PF) has been reported to have anti-inflammatory and liver-protective effects, but the underlying mechanisms remain unclear. This study aimed investigate effect PF on crosstalk between pyroptosis NETs in AILI. (2) APAP-treated C57BL/6J mice were used demonstrate protective liver injury. HepG2 dHL-60 cells cultured effects hepatocyte neutrophil extracellular traps (NETs) vitro. Moreover, cell co-culture experiments performed, treated with NETs-depleting agent inhibitor improvement AILI induced through regulating NETs. (3) significantly alleviated Additionally, inhibited expression pyroptosis-related proteins, high-mobility group box 1 (HMGB1), NETs-associated proteins vitro vivo. The demonstrated that not only triggered pyroptosis, also suppressed In depleted neutrophils, level notably decreased, indicating diminished impact PF. Similarly, formation was reduced receiving compared APAP group. Compared DNase I alone, reduction combined serum ALT AST levels decreased from 46.857% 39.927% 44.347% 33.419%, respectively. DSF 45.347% 36.419%, (4) therapeutic Its mechanism involves regulation research substantiates pharmacological promise as intervention for acute

Язык: Английский

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α5-nAChR/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

α5-nicotinic acetylcholine receptor (α5‐nAChR) participates in chronic stress-promoted lung adenocarcinoma (LUAD) progression. Neuropilin and tolloid-like 2 (NETO2) contributes to fear expression extinction, which is related tumorigenesis. CHRNA5 (encoding α5‐nAChR) gene profiling revealed a reduction NETO2 following knockdown. Nevertheless, the connection between α5-nAChR LUAD progression induced by stress remains unclear. RNA-Seq bioinformatics database were used for analyzing as well correlation of α5-nAChR, together with LUAD. detected using immunohistochemistry tissue microarrays, restraint (CRS) unpredictable (CUMS) mice tissues. In A549 H1299 cells, NETO2, p-CAMKII, p-STAT3 vimentin acetylcholine/nicotine was examined western blot. The interaction cells Co-immunoprecipitation assay modeled molecular docking. EdU colony formation conducted evaluate cell proliferation, while wound healing transwell assessed migration invasion cells. expression, low survival rate, staging smoking status dataset microarrays. validated nude xenograft correlated CRS CUMS vitro, mediated via α5-nAChR. interacted CAMKII α5-nAChR/NETO2 signaling contributed invasion. above results uncover new pathway: axis

Язык: Английский

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“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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