Endocrine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Abstract Cerebral amyloid angiopathy (CAA) is the leading cause of vascular dementia among elderly. Neuropsychiatric symptoms are commonly manifested in cerebral patients but usually considered as consequences pathology. Here, it reported that chronic stress promotes progression, which enhances deposition protein beta (Aβ) brain blood vessels and exacerbates subsequent injury. Mechanistically, neutrophil implicated development. Aβ accumulates vasculature induces extracellular traps (NETs) by activating STAT6 signaling, inhibits apoptosis switches programmed cell death toward NETosis. During stress, circulatory Norepinephrine (NE) strengthens activation NET formation, thus NET‐dependent angiopathy. It demonstrated inhibiting chemotaxis towards or suppressing formation both ameliorate severity context stress. Therefore, proposed stress‐associated psychological disorders NETs promising therapeutic targets
Язык: Английский
Процитировано
3
Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(1)
Опубликована: Янв. 20, 2025
Nerve signaling within the tumor microenvironment (TME) plays a critical role in initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior activation upon injury cancer onset, this review specifically focuses on how sympathetic nerves rewire TME. Within tumors, closely interact with various TME components, combined often shifts tumor-intrinsic physiology toward tumor-supportive phenotypes. In turn, such as myeloid cells, lymphoid extracellular matrix (ECM), endothelial associated fibroblasts (CAFs), Schwann secrete neurotrophic axon guidance factors that influence both outgrowth cell behavior, further exacerbating progression metastasis. Here, we current evidence multidirectional impacts immune non-immune nature these communication processes, exploring interactions may inform future therapeutics impair
Язык: Английский
Процитировано
0
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 21, 2025
Abstract Aging is an inevitable physiological process in organisms, and the development of tumors closely associated with cellular senescence. This article initially examines role senescence tumorigenesis, emphasizing correlation between telomere length—a marker senescence—and tumor risk. Concurrently, study explores expression levels senescence-associated markers, such as p16, p53, mTOR, context development. Additionally, investigates impact on organismal senescence, including effects immune system function metabolic processes. Ultimately, discussion potential application anti-aging strategies therapy considers possibility utilizing mechanisms a novel therapeutic approach for tumors. research provides insights into complex interplay development, suggesting future preventative measures interventions.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
The present immune therapy was focused on the checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate innate system antitumor still lags out. Neutrophils are most abundant circulating leukocytes in human, and heterogeneous neutrophils have been increasingly recognized as important players tumor progression. They play double “edge-sward” by either supporting suppressing growth, including driving angiogenesis, extracellular matrix remodeling promote participating adaptive immunity, killing cells directly inhibit growth. complex role of various tumors depends microenvironment (TME) they located, emerging evidence has suggested that may determine success immunotherapy context blockade, training, drug-loaded microvesicles therapy, which makes them become an exciting target for immunotherapy, with challenges. Here, we summarize latest insights immunity discuss advances neutrophil-targeted strategies.
Язык: Английский
Процитировано
0
Endocrine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0