Lipid mediators in neutrophil biology: inflammation, resolution and beyond DOI

Anita Ghodsi,

Andrés Hidalgo, Stephania Libreros

et al.

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Purpose of review Acute inflammation is the body's first defense in response to pathogens or injury. Failure efficiently resolve inflammatory insult can severely affect tissue homeostasis, leading chronic inflammation. Neutrophils play a pivotal role eradicating infectious pathogens, orchestrating initiation and resolution acute inflammation, maintaining physiological functions. The highly orchestrated biochemical process, partially modulated by novel class endogenous lipid mediators known as specialized pro-resolving (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR). Recent findings This focuses on recent advances understanding multifaceted functions SPMs, detailing roles expediting neutrophil apoptosis, promoting clearance macrophages, regulating excessive infiltration at sites, bone marrow deployment, also enhances phagocytosis repair mechanisms under both pathological conditions. We focus functions, differentiation, highlight open questions about SPMs’ heterogeneity. Summary mitigating hyperactivity within milieus, notably conditions such sepsis, cardiovascular disease, ischemic events, cancer. significant function highlights promising therapeutic agents management disorders.

Language: Английский

Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver DOI Creative Commons
Dean G. Tang

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(8)

Published: April 14, 2025

Castration-resistant prostate cancer frequently metastasizes to the liver, and liver metastases often present a neuroendocrine phenotype (i.e., [NEPC]), but underlying molecular underpinnings remain unclear. In this issue of JCI, Liu et al. demonstrate that neurotransmitter serotonin (also known as 5-hydroxytryptamine), produced by NEPC cells, gained access activated neutrophils modifying histone 3 (H3) form neutrophil extracellular traps, which in turn promoted macrometastases liver. The study suggests blocking transport inhibiting enzymes catalyze serotonin-mediated H3 modifications may represent alternative approaches treating metastases.

Language: Английский

Citations

0
Decoding the Neuroimmune Axis in Colorectal Cancer: From Neural Circuitry to Therapeutic Innovation DOI
Ying Li, Suk‐Kyun Yang,

Yongyin Zhang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy DOI Creative Commons
Abdul Ahad, Feng Leng, Hiroshi Ichise

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Residual tumor cells can persist in a dormant state during clinical remissions that may last decades. The mechanisms lead to such growth control vs. eventual reactivation and macroscopic outgrowth remain unclear. Here, we report data from mouse model reveals key role of host immunity the cellular molecular dormancy. Abrogation myeloid-specific TGF-βRII expression (TβRII myeKO ) resulted an IFN-γ rich immune microenvironment. turn elevated KLF4-mediated SLURP1 production malignant cells, which is critical cell quiescent through interruption fibronectin-integrin signaling pathways. lesions were located spatially localized niches NK cDCs, monocytes, neutrophils, concomitant with inactivation surveillance CD200-CD200R1 mechanism. Our studies identify IFN-γ-KLF4-SLURP1 axes as drivers dormancy regulated by immune-tumor crosstalk. These insights provide enhanced mechanistic understanding suitable for further investigation cancer treatment resistance prevention metastatic spread.

Language: Английский

Citations

0
Stress-induced metastasis: The NET effect DOI Creative Commons
Jing Hu

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(3), P. 335 - 337

Published: March 1, 2024

Language: Английский

Citations

3
Lipid mediators in neutrophil biology: inflammation, resolution and beyond DOI

Anita Ghodsi,

Andrés Hidalgo, Stephania Libreros

et al.

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Purpose of review Acute inflammation is the body's first defense in response to pathogens or injury. Failure efficiently resolve inflammatory insult can severely affect tissue homeostasis, leading chronic inflammation. Neutrophils play a pivotal role eradicating infectious pathogens, orchestrating initiation and resolution acute inflammation, maintaining physiological functions. The highly orchestrated biochemical process, partially modulated by novel class endogenous lipid mediators known as specialized pro-resolving (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR). Recent findings This focuses on recent advances understanding multifaceted functions SPMs, detailing roles expediting neutrophil apoptosis, promoting clearance macrophages, regulating excessive infiltration at sites, bone marrow deployment, also enhances phagocytosis repair mechanisms under both pathological conditions. We focus functions, differentiation, highlight open questions about SPMs’ heterogeneity. Summary mitigating hyperactivity within milieus, notably conditions such sepsis, cardiovascular disease, ischemic events, cancer. significant function highlights promising therapeutic agents management disorders.

Language: Английский

Citations

3