Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Окт. 31, 2022
A
metal-
and
aldehyde-free
visible-light-driven
photoredox-neutral
alkene
acylarylation
with
readily
available
cyanoarenes
is
described.
variety
of
3-(arylmethyl)chroman-4-ones
(i.e.,
homoisoflavonoids)
analogs
are
efficiently
synthesized
good
functional
group
tolerance.
This
mild
protocol
relies
on
a
phosphoranyl
radical-mediated
acyl
radical-initiated
cyclization
selective
radical-radical
coupling
sequence,
also
further
highlighted
by
subsequent
derivatization
to
chromone
2H-chromene
as
well
its
application
in
the
three-component
acylarylation.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(4), С. 2288 - 2295
Опубликована: Фев. 4, 2023
A
simple
and
practical
electron
donor-acceptor
(EDA)
strategy
to
synthesize
various
3-alkylated
coumarins
from
easily
available
naturally
abundant
carboxylic
acids
under
photocatalyst-,
oxidant-,
additive-free
mild
conditions
is
reported.
Using
Na2S
as
the
catalytic
donor,
a
series
of
primary,
secondary,
tertiary
carbon
radicals
can
be
efficiently
generated,
EDA
complex
regenerated
without
an
alkaline
additive.
Organic Letters,
Год журнала:
2023,
Номер
25(3), С. 494 - 499
Опубликована: Янв. 12, 2023
The
annulation
reactions
of
N-allylbenzamides
with
N-sulfonylaminopyridinium
salts
were
developed
under
metal-free
photoinduced
mild
conditions.
Substituent-controlled
sulfonaminoarylation
and
sulfonaminooxylation
benzamides
realized:
lead
to
benzosultams,
while
N-(2-phenylallyl)benzamides
give
sulfonamidylated
oxazoline
derivatives.
Control
experiments
indicated
that
those
undergo
a
radical
pathway
arylsulfonamidyl
radicals
as
the
intermediates.
aryl
C–H
bond
functionalization
in
was
involved
for
first
time
benzosultams.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(20)
Опубликована: Фев. 28, 2024
Abstract
We
demonstrate
that
electrochemical‐induced
decarboxylation
enables
reliable
post‐polymerization
modification
and
degradation
of
polymers.
Polymers
containing
N
‐(acryloxy)phthalimides
were
subjected
to
electrochemical
under
mild
conditions,
which
led
the
formation
transient
alkyl
radicals.
By
installing
these
redox‐active
units,
we
systematically
modified
pendent
groups
chain
ends
polyacrylates.
This
approach
enabled
production
poly(ethylene‐
co
‐methyl
acrylate)
poly(propylene‐
copolymers,
are
difficult
synthesize
by
direct
polymerization.
Spectroscopic
chromatographic
techniques
reveal
transformations
near‐quantitative
on
several
polymer
systems.
Electrochemical
also
all‐methacrylate
poly(
‐(methacryloxy)phthalimide‐
methacrylate)
copolymers
with
a
efficiency
>95
%.
Chain
cleavage
is
achieved
through
‐hydroxyphthalimide
ester
subsequent
β‐scission
backbone
radical.
Electrochemistry
thus
shown
be
powerful
tool
in
selective
controlled
macromolecular
degradation.
Catalysts,
Год журнала:
2023,
Номер
13(4), С. 761 - 761
Опубликована: Апрель 16, 2023
Acetonitrile
is
commonly
used
as
an
organic
solvent
and
can
also
be
important
intermediate
in
synthesis.
Its
widespread
use
has
led
to
the
development
of
new
methods
for
synthesis
a
variety
compounds.
In
past
decades,
conversion
reactions
acetonitrile
building
block
have
become
one
most-attractive
fields
Especially
field
electrochemical
conversions
involving
acetonitrile,
due
its
good
conductivity
environmentally
friendly
features,
it
powerful
compelling
tool
afford
nitrogen-containing
compounds
or
nitrile-containing
this
review,
we
mainly
discuss
research
progress
five
years,
covering
both
conventional
Besides,
detailed
discussion
substrate
scope
mechanistic
pathways
provided.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(7), С. 3755 - 3762
Опубликована: Фев. 12, 2024
Picolinamide
fungicides,
structurally
related
to
UK-2A
and
antimycin-A,
bind
into
the
Qi-site
in
bc1
complex.
However,
detailed
binding
mode
of
picolinamide
fungicides
remains
unknown.
In
present
study,
antimycin-A
were
selected
study
inhibitors
with
four
protonation
states
by
integrating
molecular
dynamics
simulation,
docking,
mechanics
Generalized
Born
surface
area
(MM/GBSA)
calculations.
Subsequently,
a
series
new
derivatives
designed
synthesized
further
understand
effects
substituents
on
tail
phenyl
ring.
The
computational
results
indicated
that
substituted
aromatic
rings
pharmacophore
fragments
made
primary
contribution
when
bound
protein.
Compound
9g-hydrolysis
formed
H-bonds
Hie201
Ash228
showed
an
IC50
value
6.05
±
0.24
μM
against
porcine
9c,
simpler
chemical
structure,
higher
control
than
florylpicoxamid
cucumber
downy
mildew
expanded
fungicidal
spectrum
fungicides.
structural
mechanistic
insights
obtained
from
will
provide
valuable
clue
for
future
designing
promising
inhibitors.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(47), С. 18292 - 18300
Опубликована: Сен. 22, 2023
Scaffold
hopping
strategy
has
become
one
of
the
most
successful
methods
in
process
molecular
design.
Seeking
to
develop
novel
succinate
dehydrogenase
inhibitors
(SDHIs),
we
employed
a
scaffold
design
compounds
featuring
geminate
dichloralkenes
(gem-dichloralkenes)
fragment.
After
stepwise
modifications,
series
N-cyclopropyl-dichloralkenes-pyrazole-carboxamide
derivatives
was
synthesized.
Among
them,
G28
(IC50
=
26.00
nM)
and
G40
27.00
were
identified
as
best
inhibitory
activity
against
porcine
SDH,
with
IC50
values
reaching
nanomolar
range,
outperforming
lead
compound
pydiflumetofen.
Additionally,
greenhouse
assay
indicated
that
G37
(EC90
0.031
mg/L)
G34
1.67
displayed
extremely
high
activities
wheat
powdery
mildew
(WPM)
cucumber
(CPM),
respectively.
Computational
results
further
revealed
gem-dichloralkene
fragment
fluorine
substituted
pyrazole
form
an
extra
hydrophobic
interaction
dipolar-dipolar
SDH.
In
summary,
our
study
provides
outstanding
fungicidal
properties,
obtained
through
hopping,
holds
great
potential
for
future
research
on
PM
control.
Organic Letters,
Год журнала:
2023,
Номер
25(14), С. 2466 - 2470
Опубликована: Март 31, 2023
A
novel
and
green
photocatalytic
strategy
for
the
synthesis
of
C-4-acylated
coumarins
with
α-keto
acids
3-nitrocoumarin
has
been
developed.
This
operationally
simple
protocol
works
under
mild
reaction
conditions,
providing
convenient
access
to
4-acyl
coumarin
derivatives.
The
control
experimental
results
showed
that
nitro
radical
produced
by
cleavage
C-N
bond
acts
as
an
electron
acceptor
complete
cycle,
achieving
a
redox-neutral
reaction.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(21), С. 14177 - 14185
Опубликована: Сен. 29, 2022
The
photoredox-catalyzed
radical
difluoroalkylation/cyclization/hydroxylation
cascade
reaction
of
various
2-bromo-2,2-difluoro-N-arylacetamides
containing
unactivated
alkene
moieties
has
been
developed,
providing
green
and
efficient
access
to
4-hydroxyalkyl-3,3-difluoro-γ-lactams.
Control
experiments
confirmed
a
process,
inexpensive
air
acted
as
the
sole
hydroxy
resource.
In
addition,
highlights
this
protocol
include
good
tolerance
for
variety
functional
groups,
lower
photocatalyst
loading,
ease
operation.
