The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Alcohols
are
the
most
commercially
abundant,
synthetically
versatile
and
operationally
convenient
functional
groups
in
organic
chemistry.
Therefore,
a
strategy
that
utilizes
hydroxy-containing
compounds
to
develop
novel
bond
disconnection
formation
process
would
achieve
molecular
diversity.
Herein,
deconstructive
for
generation
of
quinoxalin-2(1H)-one
derivatives
has
been
developed
from
alcohol
precursors
via
oxy-radical-induced
β-fragmentation.
Additionally,
1,5-HAT
deoxygenation
by
P(III)
along
with
oxy-radical
were
demonstrated
as
alternative
pathways
this
transformation.
Furthermore,
deep-seated
reorganization
few
terpenes
carbon
framework,
unique
activity
inhibition
against
growth
pathogenic
fungi
was
observed.
Green Chemistry,
Год журнала:
2023,
Номер
25(8), С. 3292 - 3296
Опубликована: Янв. 1, 2023
The
semi-heterogeneous
g-C
3
N
4
/NaI
dual
catalytic
system
driven
C–C
bond
formation
between
quinoxalin-2(1
H
)-ones
and
arylhydrazines
under
blue
light
irradiation
is
reported
for
the
first
time.
Green Chemistry,
Год журнала:
2023,
Номер
25(14), С. 5539 - 5542
Опубликована: Янв. 1, 2023
With
formaldehyde
as
an
atom-economical
carbonyl
synthon,
the
EtOH-catalyzed
electrochemical
multicomponent
synthesis
of
various
imidazolidine-fused
sulfamidates
under
organic
oxidant-free,
energy-saving
and
mild
conditions
was
developed.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 19, 2024
This
comprehensive
review,
covering
2021-2023,
explores
the
multifaceted
chemical
and
pharmacological
potential
of
coumarins,
emphasizing
their
significance
as
versatile
natural
derivatives
in
medicinal
chemistry.
The
synthesis
functionalization
coumarins
have
advanced
with
innovative
strategies.
enabled
incorporation
diverse
functional
fragments
or
construction
supplementary
cyclic
architectures,
thereby
biological
physico-chemical
properties
compounds
obtained
were
enhanced.
unique
structure
coumarine
facilitates
binding
to
various
targets
through
hydrophobic
interactions
pi-stacking,
hydrogen
bonding,
dipole-dipole
interactions.
Therefore,
this
important
scaffold
exhibits
promising
applications
uncountable
fields
chemistry
(e.g.,
neurodegenerative
diseases,
cancer,
inflammation).
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10614 - 10623
Опубликована: Июль 25, 2024
A
photocatalyst-free
and
EDA
complex-enabled
radical
cascade
cyclization
reaction
of
inactive
alkenes
with
bromodifluoroacetamides
was
reported
for
the
divergent
synthesis
fluorine-containing
tetralones
quinazolinones.
In
this
transformation,
persulfates
as
electron
donors
difluoro
bromamide
acceptors
generate
complex.
This
is
a
promising
photochemical
method
advantages
such
mild
conditions,
simple
operation,
being
metal-free,
excellent
functional
group
tolerance.
A
green
and
practical
method
for
the
electrochemical
synthesis
of
tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
through
three-component
reaction
quinoxalin-2(1H)-ones,
N-arylglycines
paraformaldehyde
was
reported.
In
this
strategy,
EtOH
played
dual
roles
(eco-friendly
solvent
waste-free
pre-catalyst)
in
situ
generated
ethoxide
promoted
triple
sequential
deprotonations.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(13), С. 8360 - 8368
Опубликована: Июнь 1, 2023
A
1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene
(4-CzIPN)-photocatalyzed
cascade
arylation/cyclization
reaction
of
2-isocyanobiaryls
and
iodonium
ylides
was
established
for
the
synthesis
6-arylated
phenanthridines.
This
is
first
example
employing
as
aryl
radical
sources
in
a
visible-light-induced
cyclization
reaction.
