Chemical Communications, Год журнала: 2024, Номер 60(71), С. 9550 - 9553
Опубликована: Янв. 1, 2024
A near-infrared light-driven Janus nanomotor with excellent motility and collagenase activity is constructed, which can potently penetrate into tumors significantly enhance anti-tumor immune efficacy.
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Фев. 24, 2024
Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, producing anticancer microbial agents situ to suppress growth. Despite the unique advantages of bacteria-based biotherapy, insufficient efficiency limits its application complete ablation malignant tumors. The combination nanomedicine engineered has attracted increasing attention owing their striking synergistic effects treatment. that function as natural vehicles effectively deliver nanomedicines sites. Moreover, provide an opportunity enhance by modulating TME substrates support nanomedicine-mediated reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, catalytic properties, plays important role promoting bacteria-mediated biotherapies. therapy comprehensively summarized this review. Attention is paid not only fabrication nanobiohybrid composites, but also interpromotion mechanism between therapy. Additionally, recent advances bacteria-synergized multimodal therapies highlighted.
Язык: Английский
Процитировано
16
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 8, 2025
Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2022, Номер 16(9), С. 13821 - 13833
Опубликована: Авг. 22, 2022
To address the low response rate to immune checkpoint blockade (ICB) therapy, we propose a specific promoter-driven CRISPR/Cas9 system, F-PC/pHCP, that achieves permanent genomic disruption of PD-L1 and elicits multifaceted anticancer potentiate immunotherapy. This system consists chlorin e6-encapsulated fluorinated dendrimer HSP70-promoter-driven CRISPR/Cas9. F-PC/pHCP under 660 nm laser activated HSP70 promoter enabled expression Cas9 protein disrupt gene, preventing escape. Moreover, also induced immunogenic cell death (ICD) tumor cells reprogrammed immunosuppressive microenvironment. Overall, this showed great efficacy and, more importantly, stimulated an memory inhibit distant growth lung metastasis. represents alternative strategy for ICB therapy as well enhanced cancer
Язык: Английский
Процитировано
36
Advanced Science, Год журнала: 2023, Номер 10(35)
Опубликована: Окт. 24, 2023
Abstract Patients with colorectal cancer (CRC) and diffuse peritoneal metastasis (PM) are not eligible for surgical intervention. Thus, palliative treatment remains the standard of care in clinical practice. Systemic chemotherapy fails to cause drug accumulation at lesion sites, while intraperitoneal (IPC) is limited by high clearance rates associated complications. Given poor prognosis, a customized OxP/R848@PLEL hydrogel delivery system has been devised improve benefit advanced CRC PM. This distinguished its simplicity, security, efficiency. Specifically, PLEL exhibits excellent injectability thermosensitivity, enabling formation depots within abdominal cavity, rendering it an optimal carrier IPC. Oxaliplatin (OxP), first‐line CRC, cytotoxic enhances immunogenicity tumors inducing immunogenic cell death. Furthermore, OxP resiquimod (R848) synergistically enhance maturation dendritic cells, promote expansion T lymphocytes, induce central memory cells. Moreover, R848 domesticates macrophages anti‐tumor phenotype. effectively eradicates metastases, completely inhibits ascites production, significantly prolongs mice lifespan. As such, provides promising approach managing PM patients without indications.
Язык: Английский
Процитировано
22
International Journal of Pharmaceutics, Год журнала: 2023, Номер 634, С. 122655 - 122655
Опубликована: Янв. 30, 2023
Язык: Английский
Процитировано
20
Chinese Chemical Letters, Год журнала: 2023, Номер 35(2), С. 108536 - 108536
Опубликована: Май 6, 2023
Язык: Английский
Процитировано
19
Advanced Materials, Год журнала: 2023, Номер 35(41)
Опубликована: Июнь 1, 2023
The journey of ceramics in medicine has been synchronized with an evolution from the first generation-alumina, zirconia, etc.-to third -3D scaffolds. There is up-and-coming member called oxygen-deficient or colored bioceramics, which have recently found their way through biomedical applications. oxygen vacancy steers light absorption toward visible and near infrared regions, making bioceramics multifunctional-therapeutic, diagnostic, regenerative. Oxygen-deficient are capable turning into heat reactive species for photothermal photodynamic therapies, respectively, concomitantly yield photoacoustic images. Different types developed various synthesis routes. Some them like TiO2-x , MoO3-x WOx more investigated applications, whereas rest yet to be scrutinized. most prominent advantage these over other biomaterials multifunctionality endowed a change microstructure. some challenges ahead this category discussed at end present review. By shedding on born subcategory, it believed that field will undergo big step further as platforms naturally multifunctional.
Язык: Английский
Процитировано
18
Small Methods, Год журнала: 2023, Номер 8(8)
Опубликована: Дек. 12, 2023
Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against various cancers. However, its clinical application severely limited by poor water solubility, easy inactivation, and severe toxicity. Structural modifications nanoformulations represent two crucial avenues for camptothecin's development. the potential further structural limited, camptothecin nanoparticles fabricated via physical loading have drawbacks of low drug leakage. Prodrug-based CPT shown unique advantages, including increased loading, reduced burst release, improved bioavailability, minimal toxic side effects. Stimulus-responsive nano-prodrugs that respond to endogenous or exogenous stimuli introducing activatable linkers achieve spatiotemporally responsive release at tumor site. This review comprehensively summarizes latest research advances in stimulus-responsive nano-prodrugs, preparation strategies, mechanisms, their applications cancer therapy. Special focus placed on mechanisms characteristics treatment. Furthermore, prodrugs are discussed. Finally, challenges future directions be valuable readers engaged prodrug expected.
Язык: Английский
Процитировано
18
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 4, 2024
The limited efficacy of cancer immunotherapy occurs due to the lack spatiotemporal orchestration adaptive immune response stimulation and immunosuppressive tumor microenvironment modulation. Herein, we report a nanoplatform fabricated using pH-sensitive triblock copolymer synthesized by reversible addition-fragmentation chain transfer polymerization enabling in situ vaccination tumor-associated macrophages (TAMs) polarization. nanocarrier itself can induce melanoma immunogenic cell death (ICD) via tertiary amines thioethers concentrating on mitochondria regulate metabolism triggering endoplasmic reticulum stress upregulating gasdermin D for pyroptosis as well some features ferroptosis apoptosis. After addition ligand cyclic arginine-glycine-aspartic acid (cRGD) mannose, mixed with adjuvant resiquimod encapsulation target B16F10 cells TAMs M1 phenotype In vivo studies indicate that targeting elicits ICD, dendritic maturation, TAM polarization, cytotoxic T lymphocyte infiltration inhibits volume growth. combination checkpoint blockade, survival time mice is markedly prolonged. This study provides strategy utilizing immunoactive materials innate responses augment therapy.
Язык: Английский
Процитировано
8
Nano Today, Год журнала: 2022, Номер 48, С. 101722 - 101722
Опубликована: Дек. 16, 2022
Язык: Английский
Процитировано
26