Abstract
Next‐generation
cancer
treatments
are
expected
not
only
to
target
cells
but
also
simultaneously
train
immune
combat
while
modulating
the
immune‐suppressive
environment
of
tumors
and
hosts
ensure
a
robust
lasting
response.
Achieving
this
requires
carriers
that
can
codeliver
multiple
therapeutics
right
and/or
ensuring
patient
safety.
Nanotechnology
holds
great
potential
for
addressing
these
challenges.
This
article
highlights
recent
advances
in
nanoimmunotherapeutic
development,
with
focus
on
breast
cancer.
While
checkpoint
inhibitors
(ICIs)
have
achieved
remarkable
success
lead
cures
some
cancers,
their
response
rate
is
low.
The
poor
solid
often
associated
low
infiltration
anti‐cancer
T
an
immunosuppressive
tumor
microenvironment
(TME).
To
enhance
T‐cell
responses,
nanoparticles
employed
deliver
ICIs,
bispecific
antibodies,
cytokines,
agents
induce
immunogenic
cell
death
(ICD).
Additionally,
used
manipulate
various
components
TME,
such
as
myeloid
cells,
macrophages,
dendritic
fibroblasts
improve
activities.
Finally,
discusses
outlook,
challenges,
future
directions
nanoimmunotherapeutics.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 4, 2024
The
limited
efficacy
of
cancer
immunotherapy
occurs
due
to
the
lack
spatiotemporal
orchestration
adaptive
immune
response
stimulation
and
immunosuppressive
tumor
microenvironment
modulation.
Herein,
we
report
a
nanoplatform
fabricated
using
pH-sensitive
triblock
copolymer
synthesized
by
reversible
addition-fragmentation
chain
transfer
polymerization
enabling
in
situ
vaccination
tumor-associated
macrophages
(TAMs)
polarization.
nanocarrier
itself
can
induce
melanoma
immunogenic
cell
death
(ICD)
via
tertiary
amines
thioethers
concentrating
on
mitochondria
regulate
metabolism
triggering
endoplasmic
reticulum
stress
upregulating
gasdermin
D
for
pyroptosis
as
well
some
features
ferroptosis
apoptosis.
After
addition
ligand
cyclic
arginine-glycine-aspartic
acid
(cRGD)
mannose,
mixed
with
adjuvant
resiquimod
encapsulation
target
B16F10
cells
TAMs
M1
phenotype
In
vivo
studies
indicate
that
targeting
elicits
ICD,
dendritic
maturation,
TAM
polarization,
cytotoxic
T
lymphocyte
infiltration
inhibits
volume
growth.
combination
checkpoint
blockade,
survival
time
mice
is
markedly
prolonged.
This
study
provides
strategy
utilizing
immunoactive
materials
innate
responses
augment
therapy.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 13821 - 13833
Опубликована: Авг. 22, 2022
To
address
the
low
response
rate
to
immune
checkpoint
blockade
(ICB)
therapy,
we
propose
a
specific
promoter-driven
CRISPR/Cas9
system,
F-PC/pHCP,
that
achieves
permanent
genomic
disruption
of
PD-L1
and
elicits
multifaceted
anticancer
potentiate
immunotherapy.
This
system
consists
chlorin
e6-encapsulated
fluorinated
dendrimer
HSP70-promoter-driven
CRISPR/Cas9.
F-PC/pHCP
under
660
nm
laser
activated
HSP70
promoter
enabled
expression
Cas9
protein
disrupt
gene,
preventing
escape.
Moreover,
also
induced
immunogenic
cell
death
(ICD)
tumor
cells
reprogrammed
immunosuppressive
microenvironment.
Overall,
this
showed
great
efficacy
and,
more
importantly,
stimulated
an
memory
inhibit
distant
growth
lung
metastasis.
represents
alternative
strategy
for
ICB
therapy
as
well
enhanced
cancer
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
14(2), С. 765 - 780
Опубликована: Окт. 19, 2023
A
major
challenge
facing
photodynamic
therapy
(PDT)
is
that
the
activity
of
immune-induced
infiltrating
CD8+
T
cells
subject
to
regulatory
lymphocytes
(Tregs),
leaving
tumor
at
risk
recurrence
and
metastasis
after
initial
ablation.
To
augment
antitumor
response
reprogram
immunosuppressive
microenvironment
(TME),
a
supramolecular
nanoparticle
(DACss)
constructed
by
host-guest
interaction
between
demethylcantharidin-conjugated
β-cyclodextrin
(DMC-CD)
amantadine-terminated
disulfide-conjugated
FFVLGGGC
peptide
with
chlorin
e6
decoration
(Ad-ss-pep-Ce6)
achieve
intelligent
delivery
photosensitizer
immunomodulator
for
breast
cancer
treatment.
The
acid-labile
β-carboxamide
bond
DMC-CD
hydrolyzed
in
acidic
TME,
resulting
localized
release
DMC
subsequent
inhibition
Tregs.
guest
molecule
Ad-ss-pep-Ce6
can
be
cleaved
high
level
intracellular
GSH,
reducing
toxicity
increasing
retention
tumor.
With
significant
increase
CTL/Treg
ratio,
combination
Ce6-based
PDT
DMC-mediated
immunomodulation
adequately
achieved
spatiotemporal
regulation
remodeling
as
well
improved
primary
situ
lung
suppression
aid
PD-1
antibody.
Abstract
Patients
with
colorectal
cancer
(CRC)
and
diffuse
peritoneal
metastasis
(PM)
are
not
eligible
for
surgical
intervention.
Thus,
palliative
treatment
remains
the
standard
of
care
in
clinical
practice.
Systemic
chemotherapy
fails
to
cause
drug
accumulation
at
lesion
sites,
while
intraperitoneal
(IPC)
is
limited
by
high
clearance
rates
associated
complications.
Given
poor
prognosis,
a
customized
OxP/R848@PLEL
hydrogel
delivery
system
has
been
devised
improve
benefit
advanced
CRC
PM.
This
distinguished
its
simplicity,
security,
efficiency.
Specifically,
PLEL
exhibits
excellent
injectability
thermosensitivity,
enabling
formation
depots
within
abdominal
cavity,
rendering
it
an
optimal
carrier
IPC.
Oxaliplatin
(OxP),
first‐line
CRC,
cytotoxic
enhances
immunogenicity
tumors
inducing
immunogenic
cell
death.
Furthermore,
OxP
resiquimod
(R848)
synergistically
enhance
maturation
dendritic
cells,
promote
expansion
T
lymphocytes,
induce
central
memory
cells.
Moreover,
R848
domesticates
macrophages
anti‐tumor
phenotype.
effectively
eradicates
metastases,
completely
inhibits
ascites
production,
significantly
prolongs
mice
lifespan.
As
such,
provides
promising
approach
managing
PM
patients
without
indications.
Advanced Materials,
Год журнала:
2023,
Номер
35(41)
Опубликована: Июнь 1, 2023
The
journey
of
ceramics
in
medicine
has
been
synchronized
with
an
evolution
from
the
first
generation-alumina,
zirconia,
etc.-to
third
-3D
scaffolds.
There
is
up-and-coming
member
called
oxygen-deficient
or
colored
bioceramics,
which
have
recently
found
their
way
through
biomedical
applications.
oxygen
vacancy
steers
light
absorption
toward
visible
and
near
infrared
regions,
making
bioceramics
multifunctional-therapeutic,
diagnostic,
regenerative.
Oxygen-deficient
are
capable
turning
into
heat
reactive
species
for
photothermal
photodynamic
therapies,
respectively,
concomitantly
yield
photoacoustic
images.
Different
types
developed
various
synthesis
routes.
Some
them
like
TiO2-x
,
MoO3-x
WOx
more
investigated
applications,
whereas
rest
yet
to
be
scrutinized.
most
prominent
advantage
these
over
other
biomaterials
multifunctionality
endowed
a
change
microstructure.
some
challenges
ahead
this
category
discussed
at
end
present
review.
By
shedding
on
born
subcategory,
it
believed
that
field
will
undergo
big
step
further
as
platforms
naturally
multifunctional.
Camptothecin
(CPT)
is
a
highly
cytotoxic
molecule
with
excellent
antitumor
activity
against
various
cancers.
However,
its
clinical
application
severely
limited
by
poor
water
solubility,
easy
inactivation,
and
severe
toxicity.
Structural
modifications
nanoformulations
represent
two
crucial
avenues
for
camptothecin's
development.
the
potential
further
structural
limited,
camptothecin
nanoparticles
fabricated
via
physical
loading
have
drawbacks
of
low
drug
leakage.
Prodrug-based
CPT
shown
unique
advantages,
including
increased
loading,
reduced
burst
release,
improved
bioavailability,
minimal
toxic
side
effects.
Stimulus-responsive
nano-prodrugs
that
respond
to
endogenous
or
exogenous
stimuli
introducing
activatable
linkers
achieve
spatiotemporally
responsive
release
at
tumor
site.
This
review
comprehensively
summarizes
latest
research
advances
in
stimulus-responsive
nano-prodrugs,
preparation
strategies,
mechanisms,
their
applications
cancer
therapy.
Special
focus
placed
on
mechanisms
characteristics
treatment.
Furthermore,
prodrugs
are
discussed.
Finally,
challenges
future
directions
be
valuable
readers
engaged
prodrug
expected.
