Pharmaceutics,
Год журнала:
2023,
Номер
15(12), С. 2785 - 2785
Опубликована: Дек. 15, 2023
The
nano-delivery
system
with
a
dual
biomimetic
effect
can
penetrate
deeper
in
tumor
microenvironments
(TMEs)
and
release
sufficient
antitumor
drugs,
which
has
attracted
much
attention.
In
this
study,
we
synthesized
erythrocyte-like
mesoporous
silica
nanoparticles
(EMSNs)
as
the
core
loaded
doxorubicin
(DOX)
coated
them
calcium
phosphate
(CaP)
erythrocyte
membrane
(EM)
to
obtain
DOX/EsPMs.
transmission
electron
microscopy
(TEM),
fluorescent
co-localization
protein
bands
of
SDS-PAGE
were
used
confirm
complete
fabrication
EsPMs.
EsPMs
shape
exhibited
superior
penetration
ability
vitro
diffusion
tumor-sphere
experiments.
Intracellular
Ca
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(22)
Опубликована: Май 20, 2024
Elevated
interstitial
fluid
pressure
(IFP)
within
pathological
tissues
(e.g.,
tumors,
obstructed
kidneys,
and
cirrhotic
livers)
creates
a
significant
hindrance
to
the
transport
of
nanomedicine,
ultimately
impairing
therapeutic
efficiency.
Among
these
tissues,
solid
tumors
present
most
challenging
scenario.
While
several
strategies
through
reducing
tumor
IFP
have
been
devised
enhance
nanoparticle
delivery,
few
approaches
focus
on
modulating
intrinsic
properties
nanoparticles
effectively
counteract
during
extravasation
penetration,
which
are
precisely
stages
by
elevated
IFP.
Herein,
we
propose
an
innovative
solution
engineering
with
fusiform
shape
high
curvature,
enabling
efficient
surmounting
barriers
penetration
tissues.
Through
experimental
theoretical
analyses,
demonstrate
that
elongated
highest
mean
curvature
outperform
spherical
rod-shaped
counterparts
against
IFP,
leading
superior
intratumoral
accumulation
antitumor
efficacy.
Super-resolution
microscopy
molecular
dynamics
simulations
uncover
underlying
mechanisms
in
contributes
diminished
drag
force
high-pressure
differentials
extravasation.
Simultaneously,
facilitated
rotational
movement
augments
hopping
frequency
penetration.
This
study
addresses
limitations
posed
impediments,
uncovers
mutual
interactions
between
physical
NPs
their
environment,
presents
promising
avenue
for
advancing
cancer
treatment
nanomedicine.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
Abstract
Low
tumor
enrichment
remains
a
serious
and
urgent
problem
for
drug
delivery
in
cancer
therapy.
Accurate
targeting
of
sites
is
still
critical
aim
Though
there
have
been
variety
strategies
to
improve
the
enrichment,
biological
barriers
cause
most
delivered
guests
fail
or
be
excreted
before
they
work.
Recently,
cell
membrane-based
systems
attracted
huge
amount
attention
due
their
advantages
such
as
easy
access,
good
biocompatibility
immune
escape,
which
contribute
biomimetic
structures
specific
surface
proteins.
Furthermore,
are
referred
homologous-targeting
function
exhibit
significantly
high
adhesion
internalization
homologous-type
cells
even
though
exact
mechanism
not
entirely
revealed.
Here,
we
summarize
sources
characterizations
membrane
systems,
including
reconstructed
single
hybrid
nano-/microcarriers,
well
engineered
cells.
Additionally,
advanced
applications
these
therapy
categorized
summarized
according
components
membranes.
The
potential
factors
related
homologous
also
discussed.
By
discussing
applications,
challenges
opportunities,
expect
far-reaching
development
preclinic
clinics.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(4)
Опубликована: Фев. 15, 2024
Microneedle
array
systems
loaded
with
responsive
nanoparticles
have
received
increasing
attention
due
to
the
advantages
of
good
drug
stability,
targeting
ability,
controlled
release
drugs,
high
bioavailability,
painlessness,
and
patient
compliance.
Compared
oral
delivery,
microneedle
transdermal
delivery
eliminates
need
pass
through
gastrointestinal
tract
liver,
reducing
metabolic
consumption
drugs
by
first‐pass
effect.
While
compared
intravenous
reduces
discomfort
does
not
require
professional
administration.
However,
there
are
few
review
articles
on
microneedles
nanoparticles.
Herein,
current
researches
specific
such
as
glucose‐responsive,
pH‐responsive,
enzyme‐responsive,
light‐responsive,
magnetic‐responsive,
ultrasound‐responsive,
multiresponsive,
biomedical
application
these
summarized.
In
addition,
challenges
prospects
strategies
briefly
discussed,
which
will
facilitate
development
versatile
drug‐delivery
strategy.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2225 - 2240
Опубликована: Фев. 1, 2025
Diabetes
mellitus
(DM)
remains
a
significant
health
challenge,
with
traditional
treatments
often
failing
to
provide
lasting
solutions.
Taxifolin
(Tax),
potential
phytomedicine
antioxidant
and
anti-hyperglycemic
properties,
suffers
from
low
water
solubility
poor
bioavailability,
necessitating
advanced
delivery
systems.
This
study
aims
nanometerize
taxifolin
(Tax)
into
selenized
liposomes
(Tax-Se@LPs)
for
enhanced
oral
hypoglycemic
effect.
Tax-Se@LPs
were
fabricated
through
thin-film
hydration/in
situ
reduction
technique.
The
resulting
nanomedicine
was
characterized
in
vitro
release
studies,
pharmacokinetic
pharmacodynamic
evaluations,
cellular
uptake
assays,
formulation
stability
tests.
optimized
demonstrated
an
average
particle
size
of
185.3
nm
entrapment
efficiency
95.25%
after
optimization.
In
studies
revealed
that
exhibited
slower
more
sustained
profile
compared
conventional
liposomes,
favoring
gastrointestinal
drug
absorption.
Pharmacokinetic
evaluations
normal
rats
indicated
achieved
relative
bioavailability
216.65%,
significantly
higher
than
Tax
suspensions
unmodified
liposomes.
Furthermore,
diabetic
GK
rats,
resulted
maximal
blood
glucose
46.8%
therapeutic
duration
other
formulations.
Cellular
tests
manifested
selenization
altered
the
internalization
mechanisms
while
preserving
their
absorption
aptness
by
intestinal
epithelial
cells.
physiological
also
reinforced
selenization.
Overall,
not
only
improve
but
enhance
its
efficacy.
These
findings
underscore
as
promising
strategy
DM
management.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 18, 2025
Effective
immunotherapeutic
treatment
of
solid
tumors
has
been
greatly
challenged
by
the
complex
hostile
tumor
immunosuppressive
microenvironment
(TIME),
which
typically
involves
hypoxia
and
immunosuppression.
Herein,
a
multifunctional
biomimetic
gold
nano-modulator
(denoted
as
GNR-SNO@MMT)
was
developed
to
realize
efficient
second
near-infrared
(NIR-II)
photothermal
immunotherapy
via
targeting
deep
penetration,
vascular
normalization
immune
reprogramming.
NIR-II
agent
nanorods
(GNR)
were
grafted
with
thermosensitive
S-nitrosothiol
(SNO)
donors
camouflaged
tumor-penetrating
peptide
tLyp-1-modified
macrophage
membrane
(MM)
yield
GNR-SNO@MMT.
The
engineered
coating
increased
capacity
for
inflammatory
tropism
aided
GNR-SNO@MMT
in
ablating
together
laser
irradiation.
Moreover,
hyperthermia-stimulated
nitric
oxide
(NO)
release
situ
acted
gas
immunomodulator
effectively
enhance
blood
perfusion
reprogram
TIME
multiple
functions
(e.g.,
decreasing
PD-L1,
repolarizing
tumor-associated
macrophages,
revitalizing
cytotoxic
T
cells).
Ultimately,
inhibition
rate
against
4T1
mouse
mammary
model
mediated
plus
94.7%
2.4-fold
CD8+
cells
infiltrated
into
than
that
untreated
counterpart.
provides
an
effective
novel
photoimmunotherapy
candidate
deep-sited
through
reconfiguration
NO-involved
nanomedicine
external
assistance.
The
development
of
advanced
intracellular
delivery
systems
is
essential
for
biopharmaceutical
progress,
particularly
in
drug
systems,
genetic
engineering,
and
cellular
therapeutics.
While
nanovesicles
show
significant
therapeutic
potential,
challenges
remain
due
to
cell
membrane
barriers
the
limitations
endocytosis-mediated
pathways.
In
this
study,
we
introduce
an
efficient
acoustofluidic
system
that
utilizes
a
gigahertz
(GHz)-range
bulk
acoustic
wave
(BAW)
resonator
generate
spatiotemporally
controlled
streaming
vortices.
This
enables
rapid
(within
10
min)
highly
direct
cytosolic
by
bypassing
conventional
endosomal
entrapment
It
effectively
delivers
both
synthetic
carriers
(doxorubicin-loaded
small
unilamellar
vesicles,
Dox-SUVs)
biologically
active
exosomes
through
GHz-driven
hydrodynamic
shear
forces
induce
transient
permeability
while
maintaining
viability
(>91.5%
at
300
mW).
Key
performances
demonstrate
86.5%
efficiency
Dox-SUVs
with
near-complete
nuclear
accumulation,
exosome-mediated
exhibits
2.4-fold
accelerated
migration
3-fold
proliferation
enhancement
within
24
h.
system's
capacity
modulate
fluidic
stresses
via
BAW
power
tuning
(100-500
mW)
allows
precise
control
over
permeabilization
kinetics
cargo
flux.
By
overcoming
endolysosomal
sequestration
noninvasive,
physics-driven
mechanism,
approach
expands
opportunities
next-generation
therapeutics,
including
macromolecular
biologic
delivery,
genome
editing,
intercellular
communication.
International Journal of Pharmaceutics,
Год журнала:
2023,
Номер
646, С. 123456 - 123456
Опубликована: Сен. 29, 2023
Colorectal
cancer
(CRC)
is
one
of
the
most
common
causes
death
in
world.
The
multi-drug
resistance,
especially
metastatic
colorectal
cancer,
drives
development
new
strategies
that
secure
a
positive
outcome
and
reduce
undesirable
side
effects.
Nanotechnology
has
made
an
impact
addressing
some
pharmacokinetic
safety
issues
related
to
administration
free
therapeutic
agents.
However,
demands
managing
complex
biointerfacing
require
equally
methods
for
introducing
stimuli-responsive
or
targeting
elements.
In
order
procure
more
efficient
solution
overcoming
biological
barriers,
physiological
functions
cell
plasma
exosomal
membranes
provided
source
highly
functionalized
coatings.
Biomimetic
nanovehicles
based
on
imparted
enhanced
compatibility,
immune
escape
protection
diverse
classes
molecules.
When
loaded
with
load
used
as
coating
other
nanovehicles,
they
provide
selective
uptake.
This
review
presents
detailed
overview
recent
application
homotypic
biomimetic
management
CRC.
We
also
address
current
possibilities
challenges
associated
CRC
membrane
biomimetics.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 22, 2024
Abstract
The
confused
gene
expressions
and
molecular
mechanisms
for
mitochondrial
dysfunction
of
traditional
nanoenzymes
is
a
challenge
tumor
therapy.
Herein,
nano‐bacilliform‐enzyme
obtains
the
ability
to
inhibit
p52‐ZER6
signal
pathway,
regulate
genes
related
metabolism,
possess
GOx/CAT/POD‐like
property.
NBE
acquires
catalytic
activity
from
electronic
energy
transition.
tannin
as
(Mito)‐targeting
guide
overloads
MitoROS,
then
metabolic
disorder
lipid
peroxidation
Mito
membrane
occurs,
thus
leading
novel
death
pathway
called
PAFerroptosis
(pyroptosis,
apoptosis,
Ferroptosis).
Simultaneously,
in
order
refrain
mitophagy,
hydroxychloroquine
mixed
with
form
combo
strength
pyroptosis.
As
result,
NBE/combo
improves
obviously
by
activation
CD8+T
cells
inactivation
MDSC
cells,
up‐regulating
expression
caspase‐3
intercepting
DHODH
arrive
excellent
antitumor
effect
(93%).
Therefore,
this
study
establishes
rational
nanoenzyme
without
mitophagy
effective
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 809 - 833
Опубликована: Дек. 20, 2024
The
liver
performs
multiple
life-sustaining
functions.
Hepatic
diseases,
including
hepatitis,
cirrhosis,
and
hepatoma,
pose
significant
health
economic
burdens
globally.
Along
with
the
advances
in
nanotechnology,
mesoporous
silica
nanoparticles
(MSNs)
exhibiting
diversiform
size
shape,
distinct
morphological
properties,
favorable
physico-chemical
features
have
become
an
ideal
choice
for
drug
delivery
systems
inspire
alternative
thinking
management
of
hepatic
diseases.
Initially,
we
introduce
physiological
structure
highlight
its
intrinsic
cell
types
correlative
Next,
detail
synthesis
methods
physicochemical
properties
MSNs
their
capacity
controlled
loading
release.
Particularly,
discuss
interactions
between
respect
to
passive
targeting
mechanisms
within
by
adjusting
particle
size,
pore
diameter,
surface
charge,
hydrophobicity/hydrophilicity,
functionalization.
Subsequently,
emphasize
role
regulating
pathophysiology,
exploring
value
addressing
pathological
states,
such
as
tumors
inflammation,
combined
multi-functional
designs
intelligent
modes
enhance
minimize
side
effects.
Lastly,
put
forward
problems,
challenges,
opportunities,
well
clinical
translational
issues
faced