Radical Arylboration of Unactivated Alkenes via Visible-Light Catalysis

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

A photoinduced radical arylboration of unactivated alkenes with B2pin2 and aryl nitriles was developed, providing a mild efficient approach to access useful β-aryl boronates in the absence transition-metal catalyst. This reaction undergoes boron addition alkene subsequent radical-radical coupling process. showcases good functional group compatibility provides promising complementary strategy chemistry traditional transition-metal-catalyzed coupling.

Язык: Английский

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Palladium-Catalyzed Domino Heck/Intermolecular Cross Coupling Reaction for the Synthesis of 3-Alkyl Substituted Indene Derivatives

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(4), С. 1342 - 1342

Опубликована: Янв. 1, 2025

Язык: Английский

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Palladium/Xu-Phos-catalyzed enantioselective arylalkoxylation reaction of γ-hydroxyalkenes at room temperature

Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109879 - 109879

Опубликована: Апрель 10, 2024

Язык: Английский

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Three-component cascade carbopalladation/Heck cyclization/borylation: facile access to boryl-functionalized indenes

Chemical Communications, Год журнала: 2024, Номер 60(62), С. 8075 - 8078

Опубликована: Янв. 1, 2024

A mild Pd-catalyzed three-component cascade cyclization functionalization of

Язык: Английский

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Regio- and chemoselective hydroboration of terminal alkynes with pinacolborane catalyzed by organo rare earth metal complexes

New Journal of Chemistry, Год журнала: 2024, Номер 48(7), С. 3149 - 3155

Опубликована: Янв. 1, 2024

We herein report the regio- and chemoselective hydroboration of terminal alkynes with pinacolborane by a series constrained-geometry catalyst-type or CGC-type rare earth metal monoalkyl complexes.

Язык: Английский

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EMM-Promoted Pd-Catalyzed Solid State Intramolecular Heck-Type Cyclization/Boronation and Suzuki Couplings: Access to Functionalized Indolines

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(10), С. 6704 - 6713

Опубликована: Май 6, 2024

EMM (electromagnetic mill)-promoted Pd-catalyzed solid state intramolecular Heck-type cyclization/boronation and Suzuki couplings are reported. Compared to previous mechanochemistry that constructed one chemical bond through a cross-coupling reaction, this strategy realizes cascade transformation along with multiple formation. This conversion does not require organic solvents or additional heating, it shows good substrate scope high functional group tolerance.

Язык: Английский

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Pd/Cu-Cocatalyzed Asymmetric Cascade Heck/Tsuji–Trost Reaction to Access Non-natural Tryptophans

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

A Pd-catalyzed asymmetric Heck cascade reaction involving the intramolecular carbopalladation of unsaturated hydrocarbons, followed by nucleophilic trapping resulting palladium species, is a powerful approach for constructing chiral N-heterocycles. However, use prochiral nucleophiles in these reactions remains significantly underexplored. Herein, we report novel Pd/Cu catalytic system Heck/Tsuji–Trost allenamides and aldimine esters. This robust method allows rapid synthesis wide range enantiopure non-natural α-substituted tryptophans high yields (up to 99% yield) with excellent enantioselectivities 98% ee). Additionally, synthetic utility this protocol demonstrated through scale-up experiments diverse valuable transformations.

Язык: Английский

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Synthesis of 3-Propargyl Isoindolinones by Pd/Cu-Catalyzed Enantioselective Heck/Sonogashira Reaction of Enamides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.

Язык: Английский

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