Synthesis of 3-Propargyl Isoindolinones by Pd/Cu-Catalyzed Enantioselective Heck/Sonogashira Reaction of Enamides DOI
Qiang Wang, Ying Pan, Ren‐Xiao Liang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.

Language: Английский

Radical Arylboration of Unactivated Alkenes via Visible-Light Catalysis DOI
Xiaoyu Li, Menglin Yang, Simin Wang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

A photoinduced radical arylboration of unactivated alkenes with B2pin2 and aryl nitriles was developed, providing a mild efficient approach to access useful β-aryl boronates in the absence transition-metal catalyst. This reaction undergoes boron addition alkene subsequent radical-radical coupling process. showcases good functional group compatibility provides promising complementary strategy chemistry traditional transition-metal-catalyzed coupling.

Language: Английский

Citations

0
Palladium-Catalyzed Domino Heck/Intermolecular Cross Coupling Reaction for the Synthesis of 3-Alkyl Substituted Indene Derivatives DOI
Tuanli Yao,

Linlin Wang,

Tao Li

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(4), P. 1342 - 1342

Published: Jan. 1, 2025

Language: Английский

Citations

0
Palladium/Xu-Phos-catalyzed enantioselective arylalkoxylation reaction of γ-hydroxyalkenes at room temperature DOI
Shuai Zhu, Mingjie Chen,

Haichao Shen

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109879 - 109879

Published: April 10, 2024

Language: Английский

Citations

1
Three-component cascade carbopalladation/Heck cyclization/borylation: facile access to boryl-functionalized indenes DOI
Fei Sun,

Yiyi Zheng,

Mingxia Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(62), P. 8075 - 8078

Published: Jan. 1, 2024

A mild Pd-catalyzed three-component cascade cyclization functionalization of

Language: Английский

Citations

1
Regio- and chemoselective hydroboration of terminal alkynes with pinacolborane catalyzed by organo rare earth metal complexes DOI
Muhammad Iqbal,

Xiangqian Yan,

Ruoling Li

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(7), P. 3149 - 3155

Published: Jan. 1, 2024

We herein report the regio- and chemoselective hydroboration of terminal alkynes with pinacolborane by a series constrained-geometry catalyst-type or CGC-type rare earth metal monoalkyl complexes.

Language: Английский

Citations

0
EMM-Promoted Pd-Catalyzed Solid State Intramolecular Heck-Type Cyclization/Boronation and Suzuki Couplings: Access to Functionalized Indolines DOI

Yuwei Jia,

Hui Wang,

Jintao Guo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(10), P. 6704 - 6713

Published: May 6, 2024

EMM (electromagnetic mill)-promoted Pd-catalyzed solid state intramolecular Heck-type cyclization/boronation and Suzuki couplings are reported. Compared to previous mechanochemistry that constructed one chemical bond through a cross-coupling reaction, this strategy realizes cascade transformation along with multiple formation. This conversion does not require organic solvents or additional heating, it shows good substrate scope high functional group tolerance.

Language: Английский

Citations

0
Pd/Cu-Cocatalyzed Asymmetric Cascade Heck/Tsuji–Trost Reaction to Access Non-natural Tryptophans DOI
Panpan Li, Yang Zhang,

Zijiao Liu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

A Pd-catalyzed asymmetric Heck cascade reaction involving the intramolecular carbopalladation of unsaturated hydrocarbons, followed by nucleophilic trapping resulting palladium species, is a powerful approach for constructing chiral N-heterocycles. However, use prochiral nucleophiles in these reactions remains significantly underexplored. Herein, we report novel Pd/Cu catalytic system Heck/Tsuji–Trost allenamides and aldimine esters. This robust method allows rapid synthesis wide range enantiopure non-natural α-substituted tryptophans high yields (up to 99% yield) with excellent enantioselectivities 98% ee). Additionally, synthetic utility this protocol demonstrated through scale-up experiments diverse valuable transformations.

Language: Английский

Citations

0
Synthesis of 3-Propargyl Isoindolinones by Pd/Cu-Catalyzed Enantioselective Heck/Sonogashira Reaction of Enamides DOI
Qiang Wang, Ying Pan, Ren‐Xiao Liang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.

Language: Английский

Citations

0