Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Archives of Pharmacal Research, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Electronic Journal of Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
In the postpandemic era, to tackle engineering challenge from concurrent outbreak of routine and emerging viral respiratory infections, microfluidic-chip-based point-of-care screening multiple pathogens becomes essential for decentralized epidemic diagnosis management. Toward real-world POCT, state-of-the-art microfluidic diagnostic devices are limited by in-plane design fluidic circuit, which highly relies on external pumping apparatus sample injection distribution thus greatly hampers their portability accessibility. this work, inspired pump-free water absorption mechanism plant root hairs, we report a self-powered hand-held sensing platform simultaneous rapid nucleic acid pathogens, such as influenza A B SARS-CoV-2. This lifts liquid port out principal plane circuit harness power gravity equal distribution. The root-hair-like channels enable fast directional transport biological specimen. Cascaded recombinase polymerase amplification lateral flow assay yield visual readout three in 40 min with competitive detection sensitivity low 0.18 copies/μL, close limit qPCR (gold standard). For real clinical specimens, retrospective research shows 93.2% specificity 97.7%. From an economic perspective, unit cost down 1.4 USD per test can generally be attained. leverages biomimetic structures boost cost-efficient POCT diagnostics, particularly infrastructure-deficient areas.
Язык: Английский
Процитировано
0
Sensors, Год журнала: 2023, Номер 23(21), С. 8764 - 8764
Опубликована: Окт. 27, 2023
Coronavirus disease 2019 (COVID-19) is a caused by the infectious agent of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). The primary method diagnosing SARS-CoV-2 nucleic acid detection, but this requires specialized equipment and time consuming. Therefore, sensitive, simple, rapid, low-cost diagnostic test needed. Graphene field-effect transistor (GFET) biosensors have become most promising technology for detecting due to their advantages high sensitivity, fast-detection speed, label-free operation, low detection limit. This review mainly focus on three types GFET detect SARS-CoV-2. can quickly identify within ultra-low limits. Finally, we will outline pros cons approaches as well future directions.
Язык: Английский
Процитировано
6
Environmental Monitoring and Assessment, Год журнала: 2023, Номер 195(11)
Опубликована: Окт. 23, 2023
Язык: Английский
Процитировано
5
Diagnostics, Год журнала: 2024, Номер 14(6), С. 631 - 631
Опубликована: Март 16, 2024
This review aims to explore the role of professional diagnostic rapid testing acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management treatment in Europe, particularly Czech Republic, Poland, Romania. The paper was constructed based on a scientific evidence national international policies recommendations, as well process validation by four experts. development new technologies, options, increased awareness negative multidimensional impact ARI profiles transformed differential diagnosis into tangible desirable reality. covers following topics: (1) ARIs, (2) platforms their value, (3) policy landscape, (4) challenges barriers implementation, (5) set recommendations illustrating path forward. findings indicate that testing, including at point care (POC), can have positive case management, antimicrobial antibiotic stewardship, epidemiological surveillance, decision making. Integrating this strategy will require commitment governments academic communities, we identified room for improvement access expansion POC focus countries inclusion relevant policies.
Язык: Английский
Процитировано
1
Chinese Science Bulletin (Chinese Version), Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
晶体管基生物传感是一种结合生物受体识别功能,利用场效应晶体管器件(field-effect transistor, FET)作为信号放大和转导单元,实现生物分子或小分子特异性检测的分析方法. FET生物传感器具备响应快、无标签、高灵敏、易操作和易集成等多重优势,在疾病筛查和健康监测等生物医学领域展现出巨大的应用潜力. 本文总结了近十年在高性能FET生物传感器开发方面已取得的显著成果,重点关注于FET电学分析平台的界面调控策略和生物医学应用. 首先,我们讨论了传感元件、传感界面的调制以及识别元件的设计等界面工程改造策略. 进一步,我们对FET电学分析平台在体外检测和生理环境实时监测方面的应用进行了全面总结. 最后,我们深入探讨了FET电学分析平台在实际应用方面所面临的关键机遇和挑战,旨在为高性能FET生物传感平台和生物电子器件的设计、开发和应用提供参考.
Процитировано
1
Comprehensive analytical chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Comprehensive analytical chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(17), С. 20820 - 20828
Опубликована: Авг. 27, 2024
Fluorescent immunochromatographic test strips are critical for highly sensitive, rapid detection. However, their sensitivity detecting trace biomarkers is often affected by autofluorescence and photon absorption of the samples (nitrocellulose membrane substrates blood chromophores). Here, we report first time an strip based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) sensitive detection biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP). NIR PLNPs exhibit long (PersL) properties after excitation, allowing separation excitation detection, thereby eliminating sample interference. In addition, PersL in region greatly reduces photons sample, further improving sensitivity. After optimization, can detect NT-proBNP at levels as low 15.28 pg/mL, which covers required clinical range. The assay demonstrated a recovery rate 94–101% human serum samples, inter intrabatch coefficients variation were less than 15%. concentrations measured correlated well with those Roche electrochemiluminescence immunoassay, widely used practice. This has potential applications immediate biomarkers.
Язык: Английский
Процитировано
0