Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117343 - 117343

Published: Aug. 24, 2024

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is one of the most common malignancies in world and sixth leading cause cancer death worldwide, it urgent to find safe effective drugs for treatment. As an important therapeutic method, small-molecule are continually being updated achieve improved effects. The purpose this study was investigate structural effects various FDA-listed sorafenib, cabozantinib, lenvatinib, regorafenib on corresponding HCC targets possible optimization methods, explore mechanism identifying potential that offer better efficacy fewer side

Language: Английский

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Differential Diagnosis in the Management of Acute Respiratory Infections through Point-of-Care Rapid Testing in a Post-Pandemic Scenario in Latin America: Special Focus on COVID-19, Influenza, and Respiratory Syncytial Virus

COVID, Journal Year: 2024, Volume and Issue: 4(2), P. 221 - 260

Published: Feb. 10, 2024

This review provides a comprehensive summary of evidence to explore the role and value differential diagnosis in management Acute Respiratory Infections (ARIs) through point-of-care (POC) rapid testing post-pandemic scenario, paying particular attention coronavirus disease 2019 (COVID-19), influenza, respiratory syncytial virus (RSV). The document builds on literature policies process validation feedback by group seven experts from Latin America (LATAM). Evidence was collected understand scientific policy perspectives ARIs POC testing, with focus countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, Peru. indicates that can serve improve ARI case management, epidemiological surveillance, research innovation, evidence-based decision-making. With multiple types tests available for POC, decisions regarding which use require consideration purpose, resources, test characteristics accuracy, accessibility, affordability, results turnaround time. Based understanding current situation, this set recommendations implementation LATAM, supporting decision-making guiding efforts broad range stakeholders.

Language: Английский

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The Application of Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology: A Review

Sensors, Journal Year: 2023, Volume and Issue: 23(21), P. 8764 - 8764

Published: Oct. 27, 2023

Coronavirus disease 2019 (COVID-19) is a caused by the infectious agent of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). The primary method diagnosing SARS-CoV-2 nucleic acid detection, but this requires specialized equipment and time consuming. Therefore, sensitive, simple, rapid, low-cost diagnostic test needed. Graphene field-effect transistor (GFET) biosensors have become most promising technology for detecting due to their advantages high sensitivity, fast-detection speed, label-free operation, low detection limit. This review mainly focus on three types GFET detect SARS-CoV-2. can quickly identify within ultra-low limits. Finally, we will outline pros cons approaches as well future directions.

Language: Английский

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Strategies for efficient management of microplastics to achieve life cycle assessment and circular economy

Environmental Monitoring and Assessment, Journal Year: 2023, Volume and Issue: 195(11)

Published: Oct. 23, 2023

Language: Английский

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The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania

Diagnostics, Journal Year: 2024, Volume and Issue: 14(6), P. 631 - 631

Published: March 16, 2024

This review aims to explore the role of professional diagnostic rapid testing acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management treatment in Europe, particularly Czech Republic, Poland, Romania. The paper was constructed based on a scientific evidence national international policies recommendations, as well process validation by four experts. development new technologies, options, increased awareness negative multidimensional impact ARI profiles transformed differential diagnosis into tangible desirable reality. covers following topics: (1) ARIs, (2) platforms their value, (3) policy landscape, (4) challenges barriers implementation, (5) set recommendations illustrating path forward. findings indicate that testing, including at point care (POC), can have positive case management, antimicrobial antibiotic stewardship, epidemiological surveillance, decision making. Integrating this strategy will require commitment governments academic communities, we identified room for improvement access expansion POC focus countries inclusion relevant policies.

Language: Английский

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晶体管生物传感：界面调控策略及生物医学应用

Chinese Science Bulletin (Chinese Version), Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

晶体管基生物传感是一种结合生物受体识别功能,利用场效应晶体管器件(field-effect transistor, FET)作为信号放大和转导单元,实现生物分子或小分子特异性检测的分析方法. FET生物传感器具备响应快、无标签、高灵敏、易操作和易集成等多重优势,在疾病筛查和健康监测等生物医学领域展现出巨大的应用潜力. 本文总结了近十年在高性能FET生物传感器开发方面已取得的显著成果,重点关注于FET电学分析平台的界面调控策略和生物医学应用. 首先,我们讨论了传感元件、传感界面的调制以及识别元件的设计等界面工程改造策略. 进一步,我们对FET电学分析平台在体外检测和生理环境实时监测方面的应用进行了全面总结. 最后,我们深入探讨了FET电学分析平台在实际应用方面所面临的关键机遇和挑战,旨在为高性能FET生物传感平台和生物电子器件的设计、开发和应用提供参考.

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Lab on chip with green miniaturized technologies

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Point-of-care applications with green miniaturized technologies

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Near-infrared Persistent Luminescence Nanoparticles-Based Immunochromatographic Assay for Autofluorescence-free Detection

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20820 - 20828

Published: Aug. 27, 2024

Fluorescent immunochromatographic test strips are critical for highly sensitive, rapid detection. However, their sensitivity detecting trace biomarkers is often affected by autofluorescence and photon absorption of the samples (nitrocellulose membrane substrates blood chromophores). Here, we report first time an strip based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) sensitive detection biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP). NIR PLNPs exhibit long (PersL) properties after excitation, allowing separation excitation detection, thereby eliminating sample interference. In addition, PersL in region greatly reduces photons sample, further improving sensitivity. After optimization, can detect NT-proBNP at levels as low 15.28 pg/mL, which covers required clinical range. The assay demonstrated a recovery rate 94–101% human serum samples, inter intrabatch coefficients variation were less than 15%. concentrations measured correlated well with those Roche electrochemiluminescence immunoassay, widely used practice. This has potential applications immediate biomarkers.

Language: Английский

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Trehalose and Mannitol Based Lyoprotetion of Taq DNA Polymerase for Cold-chain-free Long-term Storage

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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