Cu Nanoparticles Decorated on Magnetic NH2-MIL-101(Fe): A Highly Active Catalyst for C–N Coupling and Reductive Degradation of Dyes

Catalysis Letters, Год журнала: 2025, Номер 155(2)

Опубликована: Янв. 2, 2025

Язык: Английский

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A facile one-pot synthesis of tetrahydrobenzo[b]pyrans and 2-amino-4H-chromenes under green conditions

RSC Advances, Год журнала: 2024, Номер 14(30), С. 21608 - 21622

Опубликована: Янв. 1, 2024

This research developed a new nanocatalyst by incorporating nanocopper iodide onto the surface of layered double hydroxides modified. enables green synthesis tetrahydrobenzo[

Язык: Английский

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Gold‐Catalyzed Highly Regioselective Hydration of Alkynylsulfonamides for Atom‐Economic Synthesis of N‐Ketosulfonamides

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 21, 2025

ABSTRACT Gold(I)‐catalyzed highly regioselective hydration of alkynylsulfonamides for synthesis N‐ketosulfonamides in 85%–96% yields. The reaction used water as a nucleophile, which had the advantages mild conditions, good functional group tolerance, high regioselectivity, yield, and 100% atomic economy (without generating by‐products or waste). This might endow this method with great potential green compounds.

Язык: Английский

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Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

Molecules, Год журнала: 2025, Номер 30(5), С. 1114 - 1114

Опубликована: Фев. 28, 2025

A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in α-functionalization ketones. The involved widening activation energy main reaction side through intermolecular interactions, thereby increasing reaction. In reaction, TMSCF3 acted as an excellent reagent which increased nucleophilicity DMF Van der Waals force reduced H2O a hydrogen bond. We found that can difference between using DFT calculations, greatly avoided formation by-products. recycled by rectification, average recovery rate 87.2%. XRD experiments, control experiments were performed support this mechanism. are confident has potential deliver significant practical advancements while simultaneously fostering broader innovation field synthesis.

Язык: Английский

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Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2243 - 2243

Опубликована: Март 2, 2025

The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to resistance against multiple disease 2019 (COVID-19) vaccines and therapeutic medications, making the development effective therapeutics SARS-CoV-2 a high priority. Studies have shown that bioactive polyphenols, particularly those with triphenol groups, can effectively inhibit activity 3-chymotrypsin-like protease (3CLpro). However, structural instability polyphenols necessitates further research. To address this, we conducted literature review identify compounds are either approved or currently undergoing clinical trials, assessing their potential 3CLpro. Exifone benserazide hydrochloride were identified as inhibitors 3CLpro among these compounds, using fluorescence resonance energy transfer (FRET)-based assay. Benserazide was confirmed covalent binder through time-dependent inhibition kinetic analysis, its binding mode elucidated by molecular docking. Notably, exifone not only inhibited but also blocked interaction between host cell receptor angiotensin-converting enzyme (ACE2) spike protein domain (S-RBD), surface plasmon (SPR) flow cytometry. Additionally, demonstrated antiviral various SARS-CoV-2-S pseudovirus variants. In conclusion, discovery underscores in developing conserved for coronaviruses, offering new strategies rapid drugs both current future pandemics.

Язык: Английский

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A crystalline Sm(III)-containing antimonotungstate with efficient catalytic activity in three-component reaction for isoindolinones synthesis

Rare Metals, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

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Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines

RSC Advances, Год журнала: 2024, Номер 14(15), С. 10761 - 10767

Опубликована: Янв. 1, 2024

The multicomponent synthesis of 2,4,6-trisubstituted pyridine via acceptorless alcohol dehydrogenation using ammonium acetate as a nitrogen source catalyzed by hydroxyapatite-supported palladium nanoparticles heterogeneous catalyst.

Язык: Английский

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Se/ZrO₂-Catalyzed Oxidative Polymerization of Aniline

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(11), С. 3392 - 3392

Опубликована: Янв. 1, 2024

Язык: Английский

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Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions

RSC Advances, Год журнала: 2024, Номер 14(12), С. 7992 - 7998

Опубликована: Янв. 1, 2024

The efficacy of green solvents and neat conditions in organocatalysed reactions were investigated. results suggest cyclopentyl methyl ether could serve as alternatives, potentially enhancing the processes' sustainability.

Язык: Английский

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The crystal structure of 2,2,5-trimethyl-3-(4-(4-(5-phenyl-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)phenyl)imidazolidin-4-one, C₂₄H₂₄N₄O₂S

Zeitschrift für Kristallographie - New Crystal Structures, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Abstract C 24 H N 4 O 2 S, orthorhombic, P 1 (no. 19) a = 5.6357(3) Å, b 18.8798(11) c 20.0148(11) V 2129.6(2) Å 3 , Z 4, R gt ( F ) 0.0668, wR ref 0.1724, T 100(2) K.

Язык: Английский

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