Miniaturized Click Chemistry and Direct Screening Facilitate the Discovery of Triazole Piperazine SARS-CoV-2 Mpro Inhibitors with Improved Metabolic Stability DOI
Shenghua Gao,

Letian Song,

Bing Ye

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design develop more direct-acting antiviral agents against highly infectious variants. Herein, we report on efficient discovery potent non-covalent non-peptide-derived M

Language: Английский

Cu Nanoparticles Decorated on Magnetic NH2-MIL-101(Fe): A Highly Active Catalyst for C–N Coupling and Reductive Degradation of Dyes DOI

Sukanya Sharma,

Vrinda Sharma, Surbhi Sharma

et al.

Catalysis Letters, Journal Year: 2025, Volume and Issue: 155(2)

Published: Jan. 2, 2025

Language: Английский

Citations

1
A facile one-pot synthesis of tetrahydrobenzo[b]pyrans and 2-amino-4H-chromenes under green conditions DOI Creative Commons

Sarieh Momeni,

Ramin Ghorbani‐Vaghei

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21608 - 21622

Published: Jan. 1, 2024

This research developed a new nanocatalyst by incorporating nanocopper iodide onto the surface of layered double hydroxides modified. enables green synthesis tetrahydrobenzo[

Language: Английский

Citations

5
Gold‐Catalyzed Highly Regioselective Hydration of Alkynylsulfonamides for Atom‐Economic Synthesis of N‐Ketosulfonamides DOI Open Access
Yuguang Wang,

Min Ma,

Yunlong Deng

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 21, 2025

ABSTRACT Gold(I)‐catalyzed highly regioselective hydration of alkynylsulfonamides for synthesis N‐ketosulfonamides in 85%–96% yields. The reaction used water as a nucleophile, which had the advantages mild conditions, good functional group tolerance, high regioselectivity, yield, and 100% atomic economy (without generating by‐products or waste). This might endow this method with great potential green compounds.

Language: Английский

Citations

0
Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones DOI Creative Commons
Hui Sun,

Liheng Yang,

Meng-Yun Fu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1114 - 1114

Published: Feb. 28, 2025

A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in α-functionalization ketones. The involved widening activation energy main reaction side through intermolecular interactions, thereby increasing reaction. In reaction, TMSCF3 acted as an excellent reagent which increased nucleophilicity DMF Van der Waals force reduced H2O a hydrogen bond. We found that can difference between using DFT calculations, greatly avoided formation by-products. recycled by rectification, average recovery rate 87.2%. XRD experiments, control experiments were performed support this mechanism. are confident has potential deliver significant practical advancements while simultaneously fostering broader innovation field synthesis.

Language: Английский

Citations

0
Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds DOI Open Access
Jiani Lu, Yan Tang, Hongtao Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2243 - 2243

Published: March 2, 2025

The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to resistance against multiple disease 2019 (COVID-19) vaccines and therapeutic medications, making the development effective therapeutics SARS-CoV-2 a high priority. Studies have shown that bioactive polyphenols, particularly those with triphenol groups, can effectively inhibit activity 3-chymotrypsin-like protease (3CLpro). However, structural instability polyphenols necessitates further research. To address this, we conducted literature review identify compounds are either approved or currently undergoing clinical trials, assessing their potential 3CLpro. Exifone benserazide hydrochloride were identified as inhibitors 3CLpro among these compounds, using fluorescence resonance energy transfer (FRET)-based assay. Benserazide was confirmed covalent binder through time-dependent inhibition kinetic analysis, its binding mode elucidated by molecular docking. Notably, exifone not only inhibited but also blocked interaction between host cell receptor angiotensin-converting enzyme (ACE2) spike protein domain (S-RBD), surface plasmon (SPR) flow cytometry. Additionally, demonstrated antiviral various SARS-CoV-2-S pseudovirus variants. In conclusion, discovery underscores in developing conserved for coronaviruses, offering new strategies rapid drugs both current future pandemics.

Language: Английский

Citations

0
A crystalline Sm(III)-containing antimonotungstate with efficient catalytic activity in three-component reaction for isoindolinones synthesis DOI

Hao-Qi Liu,

Jiawei Cao,

Wei Tang

et al.

Rare Metals, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines DOI Creative Commons

P. Hima,

M. Vageesh,

Raju Dey

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10761 - 10767

Published: Jan. 1, 2024

The multicomponent synthesis of 2,4,6-trisubstituted pyridine via acceptorless alcohol dehydrogenation using ammonium acetate as a nitrogen source catalyzed by hydroxyapatite-supported palladium nanoparticles heterogeneous catalyst.

Language: Английский

Citations

3
Se/ZrO2-Catalyzed Oxidative Polymerization of Aniline DOI

Daming Yong,

Tingting Zuo,

Qichao Wu

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(11), P. 3392 - 3392

Published: Jan. 1, 2024

Language: Английский

Citations

2
Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions DOI Creative Commons
Lloyd C. Chetty, Hendrik G. Kruger, Per I. Arvidsson

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(12), P. 7992 - 7998

Published: Jan. 1, 2024

The efficacy of green solvents and neat conditions in organocatalysed reactions were investigated. results suggest cyclopentyl methyl ether could serve as alternatives, potentially enhancing the processes' sustainability.

Language: Английский

Citations

1
The crystal structure of 2,2,5-trimethyl-3-(4-(4-(5-phenyl-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)phenyl)imidazolidin-4-one, C24H24N4O2S DOI Creative Commons
Yifan Li,

Huihui Zhong,

Yan Guo

et al.

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract C 24 H N 4 O 2 S, orthorhombic, P 1 (no. 19) a = 5.6357(3) Å, b 18.8798(11) c 20.0148(11) V 2129.6(2) Å 3 , Z 4, R gt ( F ) 0.0668, wR ref 0.1724, T 100(2) K.

Language: Английский

Citations

1