Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 135671 - 135671
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2025, Номер 165, С. 106927 - 106927
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140774 - 140774
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
1
Gels, Год журнала: 2024, Номер 10(7), С. 471 - 471
Опубликована: Июль 17, 2024
Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and capable absorbing large amounts fluid. Due to their outstanding properties, such as flexibility, tunability, biocompatibility, hydrogels have been widely employed biomedical research clinics, especially on-demand drug release. However, traditional face various limitations, e.g., delivery hydrophobic drugs due highly hydrophilic interior environment. Therefore, micelle-containing designed developed, both microenvironments enable storage diverse cargos. Based on functionalities micelles, these can be classified into micelle-doped chemically/physically types, were reported responsive varied stimuli, including temperature, pH, irradiation, electrical signal, magnetic field, etc. Here, we summarize advances provide perspectives applications field based recent studies from own lab others.
Язык: Английский
Процитировано
5
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(2)
Опубликована: Фев. 1, 2025
ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.
Язык: Английский
Процитировано
0
Journal of Polymers and the Environment, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Апрель 1, 2025
ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Окт. 24, 2024
Esophageal cancer is one of the most common cancers in world, ranking sixth cancer-related mortality. Doxorubicin (DOX), as a classic broad-spectrum, non-specific small-molecular anti-tumor drug, has achieved widespread use, including treatment esophageal cancer. However, due to its strong cardiotoxicity, poor tumor-targeting ability, and short half-life, clinical application DOX been greatly limited. In this research, we designed successfully synthesized peptide sequence IEIIIK (IEK for short) with excellent pH responsiveness. Under physiological conditions (pH 7.4), can encapsulate self-assemble into stable hydrogel (DOX-IEK) through hydrophobic electrostatic interactions. After being injected acidic tumor microenvironment, protonation degree alkaline amino acid lysine increased negative charge glutamate decreased, directly leading enhanced repulsion subsequent dissociation. Released accumulate tissue achieve efficacy. More importantly, act drug reservoir sustained release, improving targeting prolonging duration administration compensate half-life DOX, reducing systemic toxicity. Ideal efficacy both
Язык: Английский
Процитировано
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 135671 - 135671
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0