3D printed conductive hydrogel based on silk fibroin and Tetramer-Grafted-Polyethylenimine micelle for body-motion monitoring DOI

Xinyu Xue,

Lu Han, Han Cai

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135671 - 135671

Published: Oct. 1, 2024

Language: Английский

A robust visualized sericin hydrogel dressing with excellent antioxidative and antimicrobial activities facilitates diabetic wound healing DOI
Xingyue Wang, Susu Wang,

Akoumay Tehoungue

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: 165, P. 106927 - 106927

Published: Feb. 7, 2025

Language: Английский

Citations

1
Fabrication of amino-capped Pluronic F127 with aldehyde dextran chains: A strategy improving extensibility, compressibility and self-healing hydrogel for wound healing DOI

Yutao Zheng,

Pengqi Guo,

Fengyuan Yong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140774 - 140774

Published: Feb. 10, 2025

Language: Английский

Citations

1
Micelle-Containing Hydrogels and Their Applications in Biomedical Research DOI Creative Commons
Jinghua Wu, Huapeng Li, Nan Zhang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 471 - 471

Published: July 17, 2024

Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and capable absorbing large amounts fluid. Due to their outstanding properties, such as flexibility, tunability, biocompatibility, hydrogels have been widely employed biomedical research clinics, especially on-demand drug release. However, traditional face various limitations, e.g., delivery hydrophobic drugs due highly hydrophilic interior environment. Therefore, micelle-containing designed developed, both microenvironments enable storage diverse cargos. Based on functionalities micelles, these can be classified into micelle-doped chemically/physically types, were reported responsive varied stimuli, including temperature, pH, irradiation, electrical signal, magnetic field, etc. Here, we summarize advances provide perspectives applications field based recent studies from own lab others.

Language: Английский

Citations

5
Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications DOI Open Access

Farangis Shahi,

Sara Zarei,

Razhan Salah Othman

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.

Language: Английский

Citations

0
Elimination of Ofloxacin from Water Media by chitosan/kappa-carrageenan/polyvinyl alcohol/NiFe LDH Nanocomposite Hydrogel DOI
Zahra Sayyar,

M. Khadem Sadigh,

Parisa Mohammadzadeh Pakdel

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery DOI

Razhan Salah Othman,

Sara Zarei,

Hasan Rezaei Haghighat

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: April 1, 2025

ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.

Language: Английский

Citations

0
pH-sensitive supramolecular self-assembled peptide hydrogel for the treatment of esophageal cancer DOI Creative Commons

G S Ye,

Shiyao Luo,

Hajra Zafar

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

Esophageal cancer is one of the most common cancers in world, ranking sixth cancer-related mortality. Doxorubicin (DOX), as a classic broad-spectrum, non-specific small-molecular anti-tumor drug, has achieved widespread use, including treatment esophageal cancer. However, due to its strong cardiotoxicity, poor tumor-targeting ability, and short half-life, clinical application DOX been greatly limited. In this research, we designed successfully synthesized peptide sequence IEIIIK (IEK for short) with excellent pH responsiveness. Under physiological conditions (pH 7.4), can encapsulate self-assemble into stable hydrogel (DOX-IEK) through hydrophobic electrostatic interactions. After being injected acidic tumor microenvironment, protonation degree alkaline amino acid lysine increased negative charge glutamate decreased, directly leading enhanced repulsion subsequent dissociation. Released accumulate tissue achieve efficacy. More importantly, act drug reservoir sustained release, improving targeting prolonging duration administration compensate half-life DOX, reducing systemic toxicity. Ideal efficacy both

Language: Английский

Citations

0
3D printed conductive hydrogel based on silk fibroin and Tetramer-Grafted-Polyethylenimine micelle for body-motion monitoring DOI

Xinyu Xue,

Lu Han, Han Cai

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135671 - 135671

Published: Oct. 1, 2024

Language: Английский

Citations

0