Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
A
visible‐light‐induced
radical
tandem
difluoroalkylation/cyclization
to
construct
CF
2
‐containing
isoquinolinonedione
skeletons
with
methacryloyl
benzamides
is
developed.
Broad
substrate
scopes
are
compatible
metal‐,
oxidant‐
and
photocatalyst‐free
conditions
under
room
temperature
in
good‐to‐excellent
yields.
Mechanistic
analysis
revealed
that
the
transformation
initiated
by
photoinduced
electron
donor‐acceptor
(EDA)
complexes
formation.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
90(4), С. 1683 - 1696
Опубликована: Янв. 17, 2025
In
the
vanguard
of
sustainable
chemistry,
pursuit
efficient
pathways
for
synthesis
alkyl
bicyclo[1.1.1]pentane-heteroaryls
has
captured
attention
scientific
vanguard.
We
herein
report
a
groundbreaking
and
eco-conscious
multicomponent
coupling
reaction
that
paves
way
alkylation
heteroarylation
[1.1.1]propellane,
process
uniquely
enabled
by
photochemical
prowess
an
electron
donor–acceptor
(EDA)
complex.
This
method
is
distinguished
its
minimalist
yet
powerful
approach:
devoid
transition
metals,
additives,
photosensitizers.
Its
universality
further
exemplified
seamless
compatibility
broad
spectrum
halides
heteroarenes
under
standardized
conditions,
heralding
new
era
synthetic
versatility.
The
method's
practicality
underscored
capacity
late-stage
modification
pharmaceuticals,
offering
transformative
tool
enhancement
existing
drug
molecules.
Moreover,
facile
derivatization
synthesized
products
underscores
adaptability
potential
diverse
applications.
Our
mechanistic
studies
have
elucidated
underlying
radical-relay
pathway,
pinpointing
pivotal
role
EDA
complex
in
initiating
transformation.
discovery
not
only
enriches
our
fundamental
understanding
but
also
opens
avenues
strategic
optimization.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
study
describes
a
pioneering
visible-light-induced
phosphine-catalyzed
halogen-atom
transfer
(XAT)
strategy
that
heralds
new
era
in
the
difunctionalization
of
[1.1.1]propellane.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5731 - 5740
Опубликована: Янв. 1, 2024
A
simple
and
practical
method
for
the
synthesis
of
S
-alkyl
phosphorothioates/phosphorodithioates
through
three-component
reaction
cyclic
sulfonium
salts
with
8
,
H
-phosphonates,
or
P
4
10
alcohols
was
readily
developed.
Catalysts,
Год журнала:
2025,
Номер
15(2), С. 135 - 135
Опубликована: Фев. 1, 2025
Bismuth
(Bi)
is
recognized
as
a
low-toxicity
and
environmentally
friendly
metal.
Owing
to
its
diverse
oxidation
states,
Bi-based
compounds
demonstrate
exceptional
catalytic
activities
across
numerous
organic
reactions.
In
particular,
inorganic
materials
have
emerged
promising
class
of
photocatalysts
in
synthetic
chemistry.
this
review,
the
recent
applications
Bi-materials,
e.g.,
Bi2O3,
BiVO4,
BiCl3,
Bi2WO6,
Bi4O5Br2,
various
reactions,
including
C-H
oxidation,
radical
addition
olefins,
coupling
been
summarized.
The
reaction
mechanisms
are
discussed
reveal
crucial
steps
for
enhancing
performance.
Moreover,
current
challenges
prospects
vibrant
research
area
also
outlined,
aiming
provide
valuable
insights
guidance
development
more
efficient
their
pathways.
Abstract
An
efficient
metal/peroxide‐free
[5
+
1]
cyclization
of
2‐vinylanilines
with
TBN
was
realized
to
access
various
cinnolines
high
yields.
In
addition,
benzo[
e
]pyrrolo[2,1‐c][1,2,4]triazines
could
also
be
obtained
by
using
2‐(1
H
‐pyrrol‐1‐yl)anilines
as
the
raw
materials.
This
cascade
system
selected
common/low‐cost
tert
‐butyl
nitrite
N1
source,
which
performed
broad
substrate
scopes/simple
operation/mild
conditions/available
scaled
up
1
mmol.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Pd-catalyzed
photochemical
reductive
alkylation
of
quinoxalin-2(1H)-ones
and
dibenzoxazepines
with
readily
available
alkyl
bromides
has
been
developed.
The
dependence
oxidative
chemoselectivity
on
the
nature
base
was
established.
A
variety
primary,
secondary,
tertiary
halides
have
successfully
employed
in
this
transformation,
which
features
a
wide
substrate
scope
under
mild
reaction
conditions
is
also
applicable
to
dibenzoxazepines.
