Microglial‐Biomimetic Memantine‐Loaded Polydopamine Nanomedicines for Alleviating Depression
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Depression
is
a
common
psychiatric
disorder,
and
monoamine‐based
antidepressants
as
first‐line
therapy
remain
ineffective
in
some
patients.
The
synergistic
modulation
of
neuroinflammation
neuroplasticity
could
be
major
strategy
for
treating
depression.
In
this
study,
an
inflammation‐targeted
microglial
biomimetic
system,
PDA‐Mem@M,
reported
Microglial
membrane‐coated
nanoparticles
penetrate
the
blood‐brain
barrier
facilitate
targeting.
Subsequently,
owing
to
excellent
free
radical‐scavenging
capacity,
PDA‐Mem@M
attenuate
brain
inflammatory
microenvironment.
After
on‐demand
release
from
nanoparticles,
memantine
increases
expression
brain‐derived
neurotrophic
factors
reverses
loss
synaptic
dendritic
spines.
Further,
vivo
studies
demonstrate
that
effectively
alleviate
depression‐like
behaviors
greater
extent
than
or
polydopamine
(PDA)
monotherapy.
This
strategy,
with
satisfactory
biosafety
strong
anti‐inflammatory
plasticity
restoration
effects,
conducive
advances
depression
therapy.
Язык: Английский
Peroxidase-mimicking activities, photothermal, and antibiotic efficiency of silver selenide nanoparticles as an anti-methicillin-resistant Staphylococcus aureus agent
Leila Fatolahi,
Wadhah Hasan Alkhazali,
Anmar Ghanim Taki
и другие.
International Journal of Environmental Health Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Апрель 24, 2025
A
new
antibacterial
mechanism
developed
by
using
multiple
pathways
is
important
to
resolve
the
prevalence
of
antibiotic-resistant
bacteria.
This
study
shows
photothermal
properties
Ag2Se
nanoparticles
under
near-infrared
(NIR)
in
a
peroxidase-mimicking
reaction.
The
conversion
response
47.85%
808
nm
NIR
irradiation.
Moreover,
show
activity
ineffective
β-lactam
antibiotic
ceftazidime
(CAZ)
against
methicillin-resistant
Staphylococcus
aureus
(MRSA)
and
increased
membrane
permeability
MRSA.
Under
synergistic
conditions,
killed
3.8
log10
MRSA
presence
NIR,
CAZ,
H2O2,
which
higher
than
+
H2O2
(3.4
log10)
or
CAZ
(2.9
log10).
hyperthermia
generated
irradiation,
ROS
from
catalyzing
synergy
with
accounted
showed
highest
influence
Ag2Se.
Язык: Английский