Microglial‐Biomimetic Memantine‐Loaded Polydopamine Nanomedicines for Alleviating Depression DOI Open Access

Chaoqing Jiang,

Xiao Yang, Qianqian Huang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Depression is a common psychiatric disorder, and monoamine‐based antidepressants as first‐line therapy remain ineffective in some patients. The synergistic modulation of neuroinflammation neuroplasticity could be major strategy for treating depression. In this study, an inflammation‐targeted microglial biomimetic system, PDA‐Mem@M, reported Microglial membrane‐coated nanoparticles penetrate the blood‐brain barrier facilitate targeting. Subsequently, owing to excellent free radical‐scavenging capacity, PDA‐Mem@M attenuate brain inflammatory microenvironment. After on‐demand release from nanoparticles, memantine increases expression brain‐derived neurotrophic factors reverses loss synaptic dendritic spines. Further, vivo studies demonstrate that effectively alleviate depression‐like behaviors greater extent than or polydopamine (PDA) monotherapy. This strategy, with satisfactory biosafety strong anti‐inflammatory plasticity restoration effects, conducive advances depression therapy.

Language: Английский

Microglial‐Biomimetic Memantine‐Loaded Polydopamine Nanomedicines for Alleviating Depression DOI Open Access

Chaoqing Jiang,

Xiao Yang, Qianqian Huang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Depression is a common psychiatric disorder, and monoamine‐based antidepressants as first‐line therapy remain ineffective in some patients. The synergistic modulation of neuroinflammation neuroplasticity could be major strategy for treating depression. In this study, an inflammation‐targeted microglial biomimetic system, PDA‐Mem@M, reported Microglial membrane‐coated nanoparticles penetrate the blood‐brain barrier facilitate targeting. Subsequently, owing to excellent free radical‐scavenging capacity, PDA‐Mem@M attenuate brain inflammatory microenvironment. After on‐demand release from nanoparticles, memantine increases expression brain‐derived neurotrophic factors reverses loss synaptic dendritic spines. Further, vivo studies demonstrate that effectively alleviate depression‐like behaviors greater extent than or polydopamine (PDA) monotherapy. This strategy, with satisfactory biosafety strong anti‐inflammatory plasticity restoration effects, conducive advances depression therapy.

Language: Английский

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