Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

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Multicharged cyclodextrin supramolecular assemblies

Chemical Society Reviews, Год журнала: 2022, Номер 51(11), С. 4786 - 4827

Опубликована: Янв. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Язык: Английский

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Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121500 - 121500

Опубликована: Окт. 16, 2023

Cyclodextrins (CD) and derivatives are functional excipients that can improve the bioavailability of numerous drugs. Because their drug solubility improving properties they used in many pharmaceutical products. Furthermore, stability small molecular drugs be improved by incorporation CDs an unpleasant taste smell masked. In addition to well-established CD including hydroxypropyl-β-CD, hydroxypropyl-γ-CD, methylated- β-CD sulfobutylated- β-CD, there promising new development. particular, CD-based polyrotaxanes exhibiting cellular uptake enhancing properties, CD-polymer conjugates providing sustained release, enhanced uptake, mucoadhesive thiolated showing mucoadhesive, situ gelling, as well permeation will likely result innovative delivery systems. Relevant clinical trials showed various applications such formation nanoparticles, stabilizing for protein or development ready-to-use injection Advanced products making use benefical at same time. Within this review we provide overview on these recent developments take outlook how class further shape landscape delivery.

Язык: Английский

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Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(6), С. 7592 - 7608

Опубликована: Фев. 4, 2022

Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical properties are insufficient. Here, MgO nanoparticles (NPs) were incorporated into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an hydrogel (CSMP-MgO) via supramolecular combination between phosphate groups in CSMP magnesium NPs circumvent these drawbacks of chitosan-based hydrogels. Water-soluble deviate was first by grafting methacrylic anhydride phosphocreatine chain one-step lyophilization process. The this not only provides sites combine with binding but also serves as the reservoir control Mg2+ release. As result, lyophilized CSMP-MgO presented porous structure some small holes pore wall, diameters ranged from 50 100 μm. restricted swelling DI (lowest ratio 16.0 ± 1.1 g/g) no brittle failure during compression even at strain above 85% (maximum compressive strength 195.0 kPa) versus (28.0 41.3 kPa (0.5) hydrogels), regulated release stable sustained manner. promoted vitro calcium (hydroxyapatite (HA) tetracalcium (TTCP)) deposition supersaturated cytotoxicity MC3T3-E1 cells; cell osteogenic differentiation upregulation BSP, OPN, Osterix gene expression mineralization HUVEC tube formation. Among them, (5) most properties. Moreover, (CSMP-MgO (5)) showed excellent ability promote new formation calvarial defects rats. Thus, shows promise regeneration.

Язык: Английский

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Self-Healing Hydrogels: From Synthesis to Multiple Applications

ACS Materials Letters, Год журнала: 2023, Номер 5(7), С. 1787 - 1830

Опубликована: Май 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Язык: Английский

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Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Chemistry - An Asian Journal, Год журнала: 2022, Номер 17(9)

Опубликована: Март 19, 2022

Self-assembly of supramolecular hydrogels is driven by dynamic, non-covalent interactions between molecules. Considerable research effort has been exerted to fabricate and optimise that display shear-thinning, self-healing, reversibility, in order develop materials for biomedical applications. This review provides a detailed overview the chemistry behind dynamic physicochemical sustain hydrogel formation (hydrogen bonding, hydrophobic interactions, ionic metal-ligand coordination, host-guest interactions). Novel design strategies methodologies create are highlighted, which offer promise wide range applications, specifically drug delivery, wound healing, tissue engineering 3D bioprinting. To conclude, future prospects briefly discussed, consideration given steps required ultimately bring these biomaterials into clinical settings.

Язык: Английский

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Designing self-healing hydrogels for biomedical applications

Materials Horizons, Год журнала: 2023, Номер 10(10), С. 3929 - 3947

Опубликована: Янв. 1, 2023

Self-healing hydrogels based on various dynamic interactions are comprehensively summarized and their biomedical applications also thoroughly elaborated.

Язык: Английский

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Supramolecular hydrogels for wound repair and hemostasis

Materials Horizons, Год журнала: 2023, Номер 11(1), С. 37 - 101

Опубликована: Окт. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Язык: Английский

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Double network hydrogels: Design, fabrication, and application in biomedicines and foods

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 320, С. 102999 - 102999

Опубликована: Сен. 20, 2023

Язык: Английский

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Cucurbit[n]uril-based supramolecular hydrogels: Synthesis, properties and applications

Coordination Chemistry Reviews, Год журнала: 2023, Номер 489, С. 215194 - 215194

Опубликована: Май 6, 2023

Язык: Английский

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