Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Small, Год журнала: 2022, Номер 19(5)

Опубликована: Ноя. 29, 2022

Methicillin-resistant Staphylococcus aureus (MRSA)-infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings combat bacterial infections. Antibacterial hydrogels considered potential wound dressing, while their clinical translation is limited due the unpredictable risks high costs carrier excipients. it found that natural star anti-inflammatory phytochemicals baicalin (BA) sanguinarine (SAN) can directly self-assemble through non-covalent bonds such as electrostatic attraction, π-π stacking, hydrogen bonding form carrier-free binary small molecule hydrogel. In addition, BA-SAN gel exhibited synergistic inhibitory effect on MRSA. And its plasticity injectability allowed be applied dressing. Due matched physicochemical properties therapeutic effects, inhibit virulence factors, alleviate inflammation, promote healing, has good biocompatibility. The current study not only provided an hydrogel with value but also opened up new prospects designed originated from clinically used small-molecule phytochemicals.

Язык: Английский

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Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity

Small, Год журнала: 2023, Номер 19(42)

Опубликована: Июнь 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Язык: Английский

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Advanced in carbon dot-based hydrogels for antibacterial, detection and adsorption

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215457 - 215457

Опубликована: Сен. 26, 2023

Язык: Английский

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Effective Treatment of Helicobacter pylori Infection Using Supramolecular Antimicrobial Peptide Hydrogels

Biomacromolecules, Год журнала: 2024, Номер 25(3), С. 1602 - 1611

Опубликована: Фев. 7, 2024

can cause various gastric conditions including stomach cancer in an acidic environment. Although early

Язык: Английский

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Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428

Опубликована: Янв. 9, 2025

Язык: Английский

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Self‐Assembling Peptide‐Based Functional Biomaterials

ChemBioChem, Год журнала: 2022, Номер 24(2)

Опубликована: Ноя. 8, 2022

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, morphology of peptide supramolecular architecture their applications, been widely explored the merit biocompatibility, easy preparation, controllable functionality. Herein, we introduce latest research progress self-assembling peptide-based nanomaterials review biomedicine optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this will inspire rational design development novel bio-inspired future.

Язык: Английский

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Trends in Photothermal Nanostructures for Antimicrobial Applications

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9375 - 9375

Опубликована: Май 27, 2023

The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries non-availability novel antibiotics represents one most critical public health issues worldwide. Current advances nanotechnology allow new materials address drug-resistant bacterial infections specific, focused, biologically safe ways. unique physicochemical properties, biocompatibility, wide range adaptability nanomaterials that exhibit photothermal capability can be employed develop next generation photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review current state art different functional classes strategies optimise efficiency. recent achievements trends developing active nanostructures, including plasmonic metals, semiconductors, carbon-based organic polymers, mechanisms action, anti-multidrug-resistant bacteria biofilm removal, will discussed. Insights into effect various factors influencing performance, emphasising structure-performance relationship, are We examine agents' functionalisation for specific bacteria, effects near-infrared light irradiation spectrum, multimodal synergistic-based therapies minimise side maintain low costs. relevant applications presented, such antibiofilm formation, penetration or ablation, nanomaterial-based infected wound therapy. Practical employing agents, alone synergistic combination with other nanomaterials, considered. Existing challenges limitations therapy future perspectives presented from structural, functional, safety, clinical potential points view.

Язык: Английский

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Self-assembled short peptides: Recent advances and strategies for potential pharmaceutical applications

Materials Today Bio, Год журнала: 2023, Номер 20, С. 100644 - 100644

Опубликована: Апрель 26, 2023

Self-assembled short peptides have intrigued scientists due to the convenience of synthesis, good biocompatibility, low toxicity, inherent biodegradability and fast response change in physiological environment. Therefore, it is necessary present a comprehensive summary recent advances last decade regarding construction, route administration application self-assembled based on knowledge their unique specific ability self-assembly. Herein, we firstly explored molecular mechanisms self-assembly peptides, such as non-modified amino acids, well Fmoc-modified, N-functionalized, C-functionalized peptides. Next, cell penetration, fusion, peptide targeting peptide-based drug delivery were characterized. Then, common routes potential pharmaceutical applications (drug delivery, antibacterial activity, stabilizers, imaging agents, bioengineering) drugs respectively summarized. Last but not least, some general conclusions future perspectives relevant fields briefly listed. Although with certain challenges, great opportunities are offered by fascinating area development.

Язык: Английский

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A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

Coordination Chemistry Reviews, Год журнала: 2023, Номер 502, С. 215600 - 215600

Опубликована: Дек. 14, 2023

Язык: Английский

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Recent advance in tailoring the structure and functions of self-assembled peptide nanomaterials for biomedical applications

Coordination Chemistry Reviews, Год журнала: 2023, Номер 494, С. 215374 - 215374

Опубликована: Авг. 4, 2023

Язык: Английский

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