Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Small, Journal Year: 2022, Volume and Issue: 19(5)

Published: Nov. 29, 2022

Methicillin-resistant Staphylococcus aureus (MRSA)-infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings combat bacterial infections. Antibacterial hydrogels considered potential wound dressing, while their clinical translation is limited due the unpredictable risks high costs carrier excipients. it found that natural star anti-inflammatory phytochemicals baicalin (BA) sanguinarine (SAN) can directly self-assemble through non-covalent bonds such as electrostatic attraction, π-π stacking, hydrogen bonding form carrier-free binary small molecule hydrogel. In addition, BA-SAN gel exhibited synergistic inhibitory effect on MRSA. And its plasticity injectability allowed be applied dressing. Due matched physicochemical properties therapeutic effects, inhibit virulence factors, alleviate inflammation, promote healing, has good biocompatibility. The current study not only provided an hydrogel with value but also opened up new prospects designed originated from clinically used small-molecule phytochemicals.

Language: Английский

---

Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity

Small, Journal Year: 2023, Volume and Issue: 19(42)

Published: June 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Language: Английский

---

Advanced in carbon dot-based hydrogels for antibacterial, detection and adsorption

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215457 - 215457

Published: Sept. 26, 2023

Language: Английский

---

Effective Treatment of Helicobacter pylori Infection Using Supramolecular Antimicrobial Peptide Hydrogels

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(3), P. 1602 - 1611

Published: Feb. 7, 2024

can cause various gastric conditions including stomach cancer in an acidic environment. Although early

Language: Английский

---

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

---

Self-Assembled Nanoflowers from Natural Building Blocks with Antioxidant, Antibacterial, and Antibiofilm Properties

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Polyphenols, natural compounds abundant in phenolic structures, have received widespread attention due to their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them valuable for biomedical applications. However, the green synthesis of polyphenol-based materials with economical environmentally friendly strategies is great significance. In this study, a multifunctional wound dressing was achieved by introducing copper phosphate-tannic acid flower-like structure (Cu-TA NFs), which show reactive oxygen species scavenging performance. This strategy endowed electrospun dressing, composed poly(caprolactone)-coated gum arabic-poly(vinyl alcohol) nanofibers (GPP), antibacterial antibiofilm properties. Our research demonstrates that GPP/Cu-TA NFs are effective against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. Furthermore, developed showed excellent hemocompatibility biocompatibility. These results suggest synergistic properties polyphenol platform (GPP/Cu-TA NFs) make it promising candidate further development materials.

Language: Английский

---

Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria

Science Advances, Journal Year: 2025, Volume and Issue: 11(6)

Published: Feb. 5, 2025

Intracellular bacterial infections and antimicrobial resistance are threatening global public health systems. Antimicrobial peptides a potential solution to combat resistance, but the design of self-assembled nanopeptides with dual functions cell penetration antibacterial properties intracellular bacteria remains challenge. Here, we propose strategy develop through chimerization core, hydrophobic motif, cell-permeable unit. The optimal nanopeptides, F3FT N3FT, exhibited potent activity excellent biocompatibility. Crucially, N3FT able efficiently penetrate cells eliminate sniping inflammation. Moreover, kill mainly by disrupting membranes inducing excessive accumulation reactive oxygen species. have good safety therapeutic in vivo. This scheme constructing multifunctional domains provides paradigm for dealing escalating resistance.

Language: Английский

---

Self‐Assembling Peptide‐Based Functional Biomaterials

ChemBioChem, Journal Year: 2022, Volume and Issue: 24(2)

Published: Nov. 8, 2022

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, morphology of peptide supramolecular architecture their applications, been widely explored the merit biocompatibility, easy preparation, controllable functionality. Herein, we introduce latest research progress self-assembling peptide-based nanomaterials review biomedicine optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this will inspire rational design development novel bio-inspired future.

Language: Английский

---

Self-assembled short peptides: Recent advances and strategies for potential pharmaceutical applications

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100644 - 100644

Published: April 26, 2023

Self-assembled short peptides have intrigued scientists due to the convenience of synthesis, good biocompatibility, low toxicity, inherent biodegradability and fast response change in physiological environment. Therefore, it is necessary present a comprehensive summary recent advances last decade regarding construction, route administration application self-assembled based on knowledge their unique specific ability self-assembly. Herein, we firstly explored molecular mechanisms self-assembly peptides, such as non-modified amino acids, well Fmoc-modified, N-functionalized, C-functionalized peptides. Next, cell penetration, fusion, peptide targeting peptide-based drug delivery were characterized. Then, common routes potential pharmaceutical applications (drug delivery, antibacterial activity, stabilizers, imaging agents, bioengineering) drugs respectively summarized. Last but not least, some general conclusions future perspectives relevant fields briefly listed. Although with certain challenges, great opportunities are offered by fascinating area development.

Language: Английский

---

Trends in Photothermal Nanostructures for Antimicrobial Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9375 - 9375

Published: May 27, 2023

The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries non-availability novel antibiotics represents one most critical public health issues worldwide. Current advances nanotechnology allow new materials address drug-resistant bacterial infections specific, focused, biologically safe ways. unique physicochemical properties, biocompatibility, wide range adaptability nanomaterials that exhibit photothermal capability can be employed develop next generation photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review current state art different functional classes strategies optimise efficiency. recent achievements trends developing active nanostructures, including plasmonic metals, semiconductors, carbon-based organic polymers, mechanisms action, anti-multidrug-resistant bacteria biofilm removal, will discussed. Insights into effect various factors influencing performance, emphasising structure-performance relationship, are We examine agents' functionalisation for specific bacteria, effects near-infrared light irradiation spectrum, multimodal synergistic-based therapies minimise side maintain low costs. relevant applications presented, such antibiofilm formation, penetration or ablation, nanomaterial-based infected wound therapy. Practical employing agents, alone synergistic combination with other nanomaterials, considered. Existing challenges limitations therapy future perspectives presented from structural, functional, safety, clinical potential points view.

Language: Английский

---