Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
ACS Nano,
Год журнала:
2023,
Номер
17(7), С. 6833 - 6848
Опубликована: Март 28, 2023
Specific
generation
of
reactive
oxygen
species
(ROS)
within
tumors
in
situ
catalyzed
by
nanozymes
is
a
promising
strategy
for
cancer
therapeutics.
However,
it
remains
significant
challenge
to
fabricate
highly
efficient
acting
the
tumor
microenvironment.
Herein,
we
develop
bimetallic
nanozyme
(Pt50Sn50)
with
photothermal
enhancement
dual
enzymatic
activities
catalytic
therapy.
The
structures
and
PtSn
nanoclusters
(BNCs)
different
Sn
content
are
explored
evaluated
systematically.
Experimental
comparisons
show
that
Pt50Sn50
BNCs
exhibit
highest
among
all
those
investigated,
including
activity
property,
due
SnO2–x
vacancy
(Ovac)
sites
on
surface
BNCs.
Specifically,
photothermal-enhanced
peroxidase-like
catalase-like
activities,
as
well
significantly
enhanced
anticancer
efficacy
both
multicellular
spheroids
vivo
experiments.
Due
high
X-ray
attenuation
coefficient
excellent
light
absorption
also
dual-mode
imaging
capacity
computed
tomography
photoacoustic
imaging,
which
could
achieve
real-time
monitoring
therapeutic
process.
Therefore,
this
work
will
advance
development
noble-metal
optimal
composition
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(29)
Опубликована: Июнь 27, 2023
The
combination
of
chemo/chemodynamic
therapy
is
a
promising
strategy
for
improving
antitumor
efficacy.
Herein,
metal-phenolic
network
nanoparticles
(NPs)
self-assembled
from
copper
ions
and
gallic
acid
(Cu-GA)
are
developed
to
evoke
apoptosis
cuproptosis
synergistic
therapy.
Cu-GA
NPs
biodegraded
in
response
the
highly
expressed
glutathione
(GSH)
tumor
cells,
resulting
simultaneous
release
Cu+
GA.
intracellular
GSH
content
dramatically
reduced
by
released
GA,
rendering
cells
incapable
scavenging
reactive
oxygen
species
(ROS)
more
susceptible
cuproptosis.
Meanwhile,
ROS
levels
within
significantly
increased
Fenton-like
reaction
,
which
disrupts
redox
homeostasis
achieves
apoptosis-related
chemodynamic
Moreover,
massive
accumulation
further
induces
aggregation
lipoylated
dihydrolipoamide
S-acetyltransferase
downregulation
iron-sulfur
cluster
protein,
activating
enhance
efficacy
NPs.
experiments
vivo
demonstrate
that
exhibited
excellent
biosafety
superior
capacity,
can
efficiently
inhibit
growth
tumors
due
activation
specific
hydrogen
peroxide.
These
Cu-based
provide
potential
build
up
efficient
safe
cancer
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101292 - 101292
Опубликована: Апрель 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
