Abstract
The
combination
of
single‐atom
catalysts
and
vacancy
engineering
is
an
emerging
hotspot
in
the
field
catalysis.
existence
vacancies
provides
additional
adsorption
sites,
which
can
increase
capacity
diffusion
rate
reactant
molecules.
Single
atoms
have
single‐height
atom
utilization
steric
hindrance
effects.
two
synergistically
show
different
activation
synergistic
processes
on
defect
materials.
Under
effect
catalysts,
they
affect
orientation
reactants
catalyst
surface
formation
intermediate
configurations,
thereby
regulating
reaction
path
product
selectivity,
greatly
enhancing
catalytic
performance,
maximizing
material
itself.
Therefore,
between
pervacancies
realize
more
efficient,
sustainable,
economical
systems,
possessing
high‐efficiency
performance
photocatalysis,
electrocatalysis
thermocatalysis,
setting
off
a
new
wave
fields
energy
conversion,
environmental
protection,
organic
synthesis.
constructed
by
single
broad
bright
application
prospects.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(33), С. 13663 - 13671
Опубликована: Авг. 10, 2024
Rapid
and
accurate
detection
of
human
epidermal
growth
factor
receptor
2
(HER2)
is
crucial
for
the
early
diagnosis
prognosis
breast
cancer.
In
this
study,
we
reported
an
iron-manganese
ion
N-doped
carbon
single-atom
catalyst
(FeMn-NC
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
As
a
powerful
tool,
nanozyme
catalysts
broaden
the
avenues
to
implement
bio‐inspired
solutions
for
addressing
many
important
concerns,
covering
energy,
healthcare,
environment,
and
more.
Recent
endeavors,
characterized
by
atomic
precision,
have
enabled
extensive
exploration
of
single‐atom
nanozymes
(SAzymes)
with
high
catalytic
activity,
superior
substrate
selectivity,
integrated
multifunctionalities,
thus
becoming
an
emerging
field
that
bridges
nanotechnology
biology.
This
review
provides
brief
outline
progress
summarizes
latest
research
advances
regarding
SAzymes
in
biomedical
therapeutics,
mainly
including
tumor
therapy,
wound
antibacterial
tissue
anti‐inflammatory
focus
on
their
prototypical
synthesis
therapeutic
mechanisms.
Finally,
current
challenges
future
perspectives
engineering
advanced
are
also
discussed
outlooked.
It
is
anticipated
this
area
shall
provide
useful
guidance
therapy.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(4), С. 1733 - 1741
Опубликована: Янв. 16, 2024
Exosomal
miRNAs
are
considered
promising
biomarkers
for
cancer
diagnosis,
but
their
accuracy
is
severely
compromised
by
the
low
content
of
and
large
amount
exosomal
released
from
normal
cells.
Here,
we
presented
a
dual-specific
miRNA's
logical
recognition
triggered
an
entropy-driven
catalysis
(EDC)-enhanced
system
in
exosomes
accurate
detection
liver
cancer-cell-derived
miR-21
miR-122.
Taking
advantage
analytical
performance
logic
device,
excellent
membrane
penetration
gold
nanoparticles,
outstanding
amplification
ability
EDC
reaction,
this
method
exhibits
high
sensitivity
selectivity
tumor-derived
situ.
Moreover,
due
to
its
performance,
device
can
effectively
distinguish
patients
healthy
donors
determining
miRNAs.
Overall,
strategy
has
great
potential
analyzing
various
types
provides
viable
tool
improve
diagnosis.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Near-infrared
light
(NIR)-driven
photoelectrochemical
(PEC)
processes
are
mainly
faced
with
the
limitation
of
weak
photocurrents.
Here,
N-deficient
B-doped
g-C3N4/CdS
(NB-g-C3N4/CdS)
is
proposed
to
construct
a
NIR-driven
PEC
biosensor
assisted
by
CRISPR-Cas12a
system
for
determination
microRNA-21
(miRNA-21).
To
promote
optical
absorption
as
well
separation
photogenerated
electrons
and
holes
g-C3N4,
NB-g-C3N4/CdS
constructed
via
engineering
electronic
band
structure
in
terms
N
defect,
B
doping,
heterojunction,
achieving
high
performance.
obtain
luminescence
efficiency
exciting
under
NIR,
core–shell
NaYF4:Yb3+,
Tm3+@NaYF4
upconversion
nanoparticles
(UCNPs)
repaired
defects
prepared.
Furthermore,
rolling
circle
amplification
(RCA)-assisted
integrated
fragment
DNA
on
UCNPs,
sensitive
detection
miRNA-21.
On
one
hand,
uncleavaged
signal
probes
UCNPs
combined
through
π–π
stacking
interaction,
generating
photocurrents
irradiation
NIR.
other
cleavaged
which
cannot
link
exhibited
fluorescence
(FL)
signals.
The
PEC-FL
dual-mode
provides
mutual
authentication
testing
results
demonstrates
ultrasensitivity
(the
limit
1.1
fM
mode
7.0
FL
mode)
excellent
specificity,
promising
clinical
analysis
miRNA.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
The
judicious
utilization
of
antibiotics
has
established
a
robust
bulwark
for
human
health.
However,
their
improper
usage
engendered
deleterious
ramifications
on
the
environment,
underscoring
imperative
developing
efficacious
and
cost-effective
detection
degradation
platforms.
This
study
presents
sulfur-modified
iron-cobalt
bimetallic
single-atom
nitrogen-doped
carbon
catalyst
(S-FeCo-NC)
with
noncopper
active
center.
In
contrast
to
conventional
laccase,
which
utilizes
copper
as
its
center,
S-FeCo-NC
exhibits
multiple
enzyme
activities,
including
laccase-like,
peroxidase-like,
catalase-like
functions,
iron
cobalt
serving
centers.
As
proof
concept,
combined
laccase-like
functions
were
used
independent
signal
outputs,
while
multienzyme
cascade
dual-mode
assay
system
was
designed
rapid
tetracycline
(TC)
in
combination
peroxidase-like
enzymes.
this
system,
oxygen
directly
participated
catalytic
process
an
electron
acceptor,
peroxidase
efficiently
catalyzed
production
O2
from
H2O2.
elevated
concentration
offered
unique
advantage
increased
activity
enzyme,
outputs
visually
resolved
colorimetric
signals
using
stable
4-aminopyridine
oxidized
TC.
Furthermore,
generation
OH
radicals
strong
oxidative
properties,
these
carried
out
effective
decomposition
output
response
performed
differential
pulse
cyclic
voltammetry,
further
improved
sensitivity
accuracy
detection.
experimental
findings
demonstrate
that
favorable
TC
within
range
0.005-500
μM,
reaching
0.5-500
0.005-1.00
respectively,
limit
is
low
0.22
μM
1.68
nM,
respectively.
based
activity,
been
shown
significantly
enhance
also
demonstrating
stability
lower
range.
suggests
it
may
offer
novel
approach
sensitive
environmental
pollutants.
