Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Год журнала: 2023, Номер 4(2)

Опубликована: Окт. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Язык: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215434 - 215434

Опубликована: Сен. 17, 2023

Язык: Английский

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Design of Near Infrared Light‐Powered Copper Phyllosilicate Nanomotors for Cuproptosis‐Based Synergistic Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(18)

Опубликована: Янв. 23, 2024

Abstract Cuproptosis, a newly discovered cell death pathway, has shown great potential in cancer treatment. Herein, near‐infrared (NIR) light‐driven nanomotors (CuSiO 3 @Au‐Pd NMs) are designed for cuproptosis‐assisted synergistic therapy with autonomous mobility and improved cellular uptake tumor penetration. Specifically, the released Cu 2+ ions from CuSiO NMs can induce Fenton‐like reaction, leading to generation of hydroxyl radicals (·OH), accompanied by depletion glutathione within MCF‐7 cells. Additionally, also exhibit excellent photothermal effects, which further promote production ·OH, resulting intensified oxidative stress apoptosis. Moreover, enhanced permeation efficiency via movement under self‐thermophoretic forces proved using 2D experiments 3D multicellular spheroids. The resultant intracellular accumulation oligomerization lipoylated proteins, cuproptosis, along mitochondrial dysfunction pathway. More importantly, both vitro vivo show that could penetrate deeply into tumors anticancer efficacy through multimodal therapeutic methods. These findings manifest promising potentials NIR‐powered Cu‐based high maneuverability future smart therapy.

Язык: Английский

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Dendrimer/metal-phenolic nanocomplexes encapsulating CuO2 for targeted magnetic resonance imaging and enhanced ferroptosis/cuproptosis/chemodynamic therapy by regulating the tumor microenvironment

Acta Biomaterialia, Год журнала: 2024, Номер 183, С. 252 - 263

Опубликована: Май 25, 2024

Язык: Английский

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Single‐Atom Catalysts Originated from Metal–Organic Frameworks for Sulfate Radical‐Based Advanced Oxidation Processes: Critical Insights into Mechanisms

Advanced Functional Materials, Год журнала: 2023, Номер 34(6)

Опубликована: Окт. 22, 2023

Abstract The widely discussed single‐atom catalysts (SACs) are regarded as a kind of attractive material for sulfate radical‐based advanced oxidation processes (SR‐AOPs) owing to their maximum atomic utilization efficiency and outstanding stability. Currently, metal–organic frameworks (MOFs) have appeared prospective precursors building SACs due extensive chelating sites, functional adjustability, structural tunability. However, there few critical systematic reviews about the application MOF‐derived in SR‐AOPs, especially in‐depth analysis mechanisms. Therefore, this review seeks offer thorough summary development SR‐AOPs. First, unique advantages MOFs derivative thoroughly. Afterward, current synthesis strategies elaborated categorically unveil formation process single atoms coordination environments. Notably, roles different reaction sites including generation reactive species mediating electron transfer further analyzed explain mechanisms comprehensively. Thereafter, characterization techniques theoretical calculations studies also highlighted. Eventually, insights into present challenges future developments proposed, which expected enhance catalytic

Язык: Английский

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Liquid Nanoparticles for Nanocatalytic Cancer Therapy

Advanced Materials, Год журнала: 2023, Номер 35(48)

Опубликована: Сен. 6, 2023

Abstract Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐involved cancer‐therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate this critical issue, glutathione (GSH)‐responsive organosilica network employed to lock liquid drops at nanoscale via a general bottom‐up strategy achieve systemic delivery “ion drugs”. In work, sulfate radical generation donor (Na 2 S O 8 ), as paradigm drug”, entrapped into nanoparticle efficiently delivering tumor region. After further surface engineering with pH‐responsive tannic acid‐Fe 2+ framework, these nanoparticles tumor‐microenvironmental pH/GSH‐dual responsive release (Fe /Na + /S 2− ) after reaching sites, where Fe triggers generate toxic •SO 4 − •OH, effectively executing cell ferroptosis , reactive oxygen species—ROS) pyroptosis ROS). Such tumor‐responsive/specific nanoplatform highly instructive ion‐mediated nanomedicine disease treatment.

Язык: Английский

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Fenton-like Chemistry by a Copper(I) Complex and H₂O₂ Relevant to Enzyme Peroxygenase C–H Hydroxylation

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(21), С. 11735 - 11744

Опубликована: Май 17, 2023

Lytic polysaccharide monooxygenases have received significant attention as catalytic convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (i.e., using H

Язык: Английский

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Photonic control of image-guided ferroptosis cancer nanomedicine

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215532 - 215532

Опубликована: Ноя. 10, 2023

Язык: Английский

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Graphene quantum dots as metal-free nanozymes for chemodynamic therapy of cancer

Matter, Год журнала: 2024, Номер 7(3), С. 977 - 990

Опубликована: Янв. 10, 2024

Язык: Английский

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Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150

Опубликована: Март 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Язык: Английский

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