The
Natural
Product
Research
Laboratory
(NPRL)
of
China
Medical
University
Hospital
(CMUH)
was
established
in
collaboration
with
CMUH
and
Professor
Kuo-Hsiung
Lee
from
the
North
Carolina
at
Chapel
Hill.
laboratory
collection
features
over
6,000
natural
products
worldwide,
including
pure
compounds
semi-synthetic
derivatives.
This
is
most
comprehensive
fully
operational
product
database
Taiwan.
review
article
explores
history
development
NPRL
CMUH.
We
then
provide
an
overview
recent
applications
impact
artificial
intelligence
(AI)
new
drug
discovery.
Finally,
we
examine
advanced
powerful
AI-tools
related
software
to
explain
how
these
resources
can
be
utilized
research
on
large-scale
data
libraries.
presents
a
(R&D)
platform
that
combines
AI
NPRL.
believe
this
approach
will
reduce
resource
wastage
enhance
capabilities
Taiwan's
academic
industrial
sectors
biotechnology
pharmaceuticals.
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 456 - 456
Опубликована: Апрель 1, 2025
Advances
in
drug
delivery
systems
adapted
with
regenerative
medicine
have
transformed
healthcare
by
introducing
innovative
strategies
to
treat
(and
repair
many
instances)
disease-impacted
regions
of
the
human
body.
This
review
provides
a
comprehensive
analysis
latest
developments
and
challenges
integrating
technologies
medicine.
Recent
advances
technologies,
including
design
biomaterials,
localized
techniques,
controlled
release
guided
mathematical
models,
are
explored
illustrate
their
role
enhancing
therapeutic
precision
efficacy.
Additionally,
approaches
analyzed,
focus
on
extracellular
matrix
components,
stem
cell-based
therapies,
emerging
for
organ
regeneration
both
soft
hard
tissue
vitro
model
engineering.
In
particular,
also
discusses
applications
cellular
cells,
immune
endothelial
specialized
cells
such
as
chondrocytes
osteoblasts,
highlights
advancements
cell
methods
cell–cell
interaction
modulation.
addition,
future
directions
pivotal
trends
emphasizing
importance
interdisciplinary
collaboration
cutting-edge
innovations
provided
address
successful
outcomes
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 734 - 734
Опубликована: Май 29, 2024
Fluoropyrimidine
(FP)
drugs
are
central
components
of
combination
chemotherapy
regimens
for
the
treatment
colorectal
cancer
(CRC).
FP-based
has
improved
survival
outcomes
over
last
several
decades
with
much
therapeutic
benefit
derived
from
optimization
dose
and
delivery.
To
provide
further
advances
in
efficacy,
next-generation
prodrugs
nanodelivery
systems
FPs
being
developed.
This
review
focuses
on
recent
innovative
approaches
FP
that
display
promise.
We
summarize
established,
clinically
useful
prodrug
strategies,
including
capecitabine,
which
exploit
tumor-specific
enzyme
expression
optimal
anticancer
activity.
then
describe
use
DNA-based
polymers
(e.g.,
CF10)
delivery
activated
nucleotides
as
a
approach
proven
activity
pre-clinical
models
clinical
potential.
Multiple
show
promise
CRC
we
albumin-mediated
delivery,
development
mesoporous
silica
nanoparticles,
emulsion-based
metal
hydrogel-based
liposomes
lipid
nanoparticles
particular
development.
Nanodelivery
is
anticipated
to
impact
coming
years
improve
patients.
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1549 - 1549
Опубликована: Дек. 3, 2024
Nanodrug
delivery
systems
have
revolutionized
tumor
therapy
like
never
before.
By
overcoming
the
complexity
of
microenvironment
(TME)
and
bypassing
drug
resistance
mechanisms,
nanotechnology
has
shown
great
potential
to
improve
efficacy
reduce
toxic
side
effects.
This
review
examines
impact
TME
on
recent
advances
in
nanomedicine
overcome
this
challenge.
Characteristics
such
as
hypoxia,
acidity,
high
interstitial
pressure
significantly
effectiveness
chemotherapy
radiotherapy,
leading
increased
cells.
Then,
summarizes
innovative
nanocarrier
designs
for
these
microenvironmental
features,
including
hypoxia-sensitive
nanoparticles,
pH-responsive
carriers,
multifunctional
nanosystems
that
enable
targeted
release
improved
penetration
accumulation
tumors.
combining
with
therapeutic
strategies,
offers
a
novel
perspective
by
focusing
design
nanocarriers
interact
TME,
dimension
often
overlooked
similar
reviews.
We
highlight
dual
role
modulation,
emphasize
their
resistance,
look
at
future
research
directions.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 21, 2024
Natural
products-coordinated
metal
ions
to
form
the
nanomedicines
are
in
spotlight
for
cancer
therapy.
Some
natural
products
could
be
coordinated
with
forming
via
simple
and
green
environmental
self-assembly,
which
not
only
improved
bioavailability
of
products,
but
also
conferred
multiple
therapeutic
modalities
multimodal
imaging.
On
one
hand,
weak
acidity,
glutathione
(GSH)
hydrogen
peroxide
(H2O2)
overexpression
tumor
microenvironment
(TME),
such
carrier-free
further
enhanced
effect
optimizing
species
ions.
other
exert
precise
treatment
under
guidance
Hence,
this
review
summarized
research
progress
recent
years
on
application
product-coordinated
In
addition,
prospects
challenges
were
discussed,
especially
how
improve
targeting
ability
stability
assess
safety
ions,
so
as
facilitate
clinical
translation
nanomedicines.
