Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Photodynamic
therapy
(PDT)
is
a
powerful
strategy
for
tumor
with
noninvasiveness
and
desirable
efficacy.
However,
the
phototoxicity
of
photosensitizer
after
post‐PDT
major
obstacle
limiting
clinic
applications.
Herein,
nitric
oxide
(NO)‐activatable
reported
turn‐on
PDT
behavior
endoplasmic
reticulum
(ER)
targeting
ability
precise
therapy.
Four
o
‐thiophenediamine
derivatives
reaction‐tunable
donor/acceptor
push‐pull
electronic
effect
are
established,
systematic
structure
property
relationship
observation
reveals
following
features:
1)
reactivity
against
NO
can
be
improved
by
enhancing
electron
density
further
facilitated
upon
photo‐irradiation.
2)
enables
intramolecular
charge
transfer
process
evoking
photosensitizing
effect.
3)
only
derivative
ER
enrichment
exhibited
cancer
cell
ablation
compared
to
photosensitizers
localized
in
lysosome
lipid
droplet.
Thus,
efficient
inhibition
cells
both
vitro
vivo
realized
based
on
photo‐controlled
strategy.
This
work
provides
more
insights
into
developing
promising
activatable
advanced
microenvironment
trigger.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(4)
Опубликована: Янв. 17, 2024
Abstract
Malignant
tumors
seriously
threaten
human
life
and
well‐being.
Emerging
Near‐infrared
II
(NIR‐II,
1000–1700
nm)
phototheranostic
nanotechnology
integrates
diagnostic
treatment
modalities,
offering
merits
including
improved
tissue
penetration
enhanced
spatiotemporal
resolution.
This
remarkable
progress
has
opened
promising
avenues
for
advancing
tumor
theranostic
research.
The
microenvironment
(TME)
differs
from
normal
tissues,
exhibiting
distinct
attributes
such
as
hypoxia,
acidosis,
overexpressed
hydrogen
peroxide,
excess
glutathione,
other
factors.
Capitalizing
on
these
attributes,
researchers
have
developed
TME‐activatable
NIR‐II
agents
with
therapeutic
concurrently.
Therefore,
developing
activation
holds
significant
research
importance.
Currently,
is
still
in
its
preliminary
stages.
review
examines
the
recent
advances
dual‐functional
activatable
over
past
years.
It
systematically
presents
activated
by
various
TME
factors
acidity
(pH),
peroxide
(H
2
O
),
glutathione
(GSH),
sulfide
S),
enzymes,
their
hybrid.
encompasses
fluorescence
photoacoustic
imaging
diagnostics,
along
photothermal,
photodynamic,
chemodynamic,
gas
therapies
triggered
Lastly,
difficulties
opportunities
confronting
simultaneous
diagnosis
field
are
highlighted.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
103, С. 106798 - 106798
Опубликована: Фев. 1, 2024
Non-invasive
and
high
spatiotemporal
resolution
mythologies
for
the
diagnosis
treatment
of
disease
in
clinical
medicine
promote
development
modern
medicine.
Ultrasound
(US)
technology
provides
a
non-invasive,
real-time,
cost-effective
imaging
modality,
which
plays
significant
role
chemical
synthesis
translation,
especially
vivo
cancer
therapy.
On
one
hand,
US
is
usually
accompanied
by
cavitation,
leading
to
temperature
pressure,
so-called
"hot
spot",
playing
sonochemical-based
colloidal
synthesis.
Compared
with
classical
nucleation
synthetic
method,
sonochemical
strategy
presents
efficiency
fabrication
nanocrystals
due
its
fast
growth
procedure.
other
attractive
medical
treatment,
applications
increasing
novel
contrast
agents,
such
as
micro
nano
bubbles,
are
widely
used
neuromodulation,
can
breach
blood–brain
barrier
temporarily
safely,
opening
new
door
neuromodulation
In
terms
sonodynamic
therapy
US-assisted
synergetic
show
great
effects
against
immunotherapy
present
unparalleled
potentiality
compared
therapies.
Further
ultrasound
revolutionize
both
translation
improving
efficiency,
precision,
accessibility
while
reducing
environmental
impact
enhancing
patient
care.
this
paper,
we
review
biological
applications,
next
generation
technology-assisted
applications.
ACS Omega,
Год журнала:
2024,
Номер
9(14), С. 15753 - 15767
Опубликована: Март 26, 2024
Tumors
are
one
of
the
main
diseases
threatening
human
life
and
health.
The
emergence
nanotechnology
in
recent
years
has
introduced
a
novel
therapeutic
avenue
for
addressing
tumors.
Through
amalgamation
nanotechnology's
inherent
attributes
with
those
natural
enzymes,
nanozymes
have
demonstrated
ability
to
initiate
catalytic
reactions,
modulate
biological
microenvironment,
facilitate
adoption
multifaceted
approaches,
thereby
exhibiting
considerable
promise
realm
cancer
treatment.
In
this
Review,
application
chemodynamic
therapy,
radiotherapy,
photodynamic
photothermal
starvation
therapy
summarized.
Moreover,
detailed
discussion
regarding
mechanism
conferring
physiotherapeutic
functionality
upon
nanosystems
is
provided.
It
posited
that
innovative
treatment
holds
significant
potential
play
crucial
role
within
domain
nanomedicine.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(9), С. 3853 - 3858
Опубликована: Фев. 20, 2024
Detection
of
Mn2+
in
living
cells
is
important
understanding
the
roles
cellular
processes
and
investigating
its
potential
implications
various
diseases
disorders.
Toward
this
goal,
we
have
previously
selected
a
Mn2+-specific
11-5
DNAzyme
through
an
vitro
selection
method
converted
it
into
fluorescence
sensor
for
intracellular
sensing.
Despite
progress,
nucleotides
responsible
activity
are
unclear,
performance
needs
to
be
improved
order
more
effective
applications
biological
systems.
To
address
these
issues,
herein
report
site-specific
mutations
within
catalytic
domain
DNAzyme.
As
result,
successfully
identified
variant
DNAzyme,
designated
as
Mn5V,
which
exhibited
twofold
increase
compared
original
Importantly,
Mn5V
maintained
high
selectivity
over
other
competing
metal
ions.
Upon
addition
Mn2+,
higher
signal
tumor
that
This
study
therefore
provides
better
how
functions
sensitive
probe
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Photodynamic
therapy
(PDT)
is
a
powerful
strategy
for
tumor
with
noninvasiveness
and
desirable
efficacy.
However,
the
phototoxicity
of
photosensitizer
after
post‐PDT
major
obstacle
limiting
clinic
applications.
Herein,
nitric
oxide
(NO)‐activatable
reported
turn‐on
PDT
behavior
endoplasmic
reticulum
(ER)
targeting
ability
precise
therapy.
Four
o
‐thiophenediamine
derivatives
reaction‐tunable
donor/acceptor
push‐pull
electronic
effect
are
established,
systematic
structure
property
relationship
observation
reveals
following
features:
1)
reactivity
against
NO
can
be
improved
by
enhancing
electron
density
further
facilitated
upon
photo‐irradiation.
2)
enables
intramolecular
charge
transfer
process
evoking
photosensitizing
effect.
3)
only
derivative
ER
enrichment
exhibited
cancer
cell
ablation
compared
to
photosensitizers
localized
in
lysosome
lipid
droplet.
Thus,
efficient
inhibition
cells
both
vitro
vivo
realized
based
on
photo‐controlled
strategy.
This
work
provides
more
insights
into
developing
promising
activatable
advanced
microenvironment
trigger.
