Nanozyme-mediated biocatalysis as a mitochondrial oxidative stress amplifier for tumor nanocatalytic immunotherapy

Chemical Engineering Journal, Год журнала: 2023, Номер 481, С. 148270 - 148270

Опубликована: Дек. 23, 2023

Язык: Английский

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Bifunctional Cascading Nanozymes Based on Carbon Dots Promotes Photodynamic Therapy by Regulating Hypoxia and Glycolysis

ACS Nano, Год журнала: 2023, Номер 17(17), С. 16715 - 16730

Опубликована: Авг. 18, 2023

Photodynamic therapy (PDT) still faces great challenges with suitable photosensitizers, oxygen supply, and reactive species (ROS) accumulation, especially in the tumor microenvironment, feathering hypoxia, high glucose metabolism. Herein, a carbon dots (CDs)-based bifunctional nanosystem (MnZ@Au), acting as photosensitizer nanozyme cascading oxidase (GOx)- catalase (CAT)-like reactivity, was developed for improving hypoxia regulating metabolism to enhance PDT. The MnZ@Au constructed using Mn-doped CDs (Mn-CDs) core zeolitic imidazolate framework-8 (ZIF-8) shell form hybrid (MnZ), followed by anchoring ultrasmall Au nanoparticles (AuNPs) onto surface of MnZ through ion exchange situ reduction methods. catalyzed consumption generation GOx- CAT-like reactions, which further enhanced its own photothermal properties. In vitro vivo studies also confirmed that greatly improved penetration, promoted ROS PDT efficacy, leading efficient growth inhibition breast model. Besides, enabled photoacoustic (PA) imaging provide mapping Mn-CDs distribution saturation, showing real-time catalytic process vivo. 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) validated decreased uptake tumors treated MnZ@Au. Therefore, integrated design provided promising strategy utilize regulate promote PDT, finally prevent deterioration.

Язык: Английский

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Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Язык: Английский

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A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 29, 2024

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu

Язык: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Metformin-Mediated Fast Charge-Reversal Nanohybrid for Deep Penetration Piezocatalysis-Augmented Chemodynamic Immunotherapy of Cancer

ACS Nano, Год журнала: 2024, Номер 18(8), С. 6314 - 6332

Опубликована: Фев. 12, 2024

Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)- ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy cancer. Interestingly, had negative charge blood circulation, which rapidly changed into positive when exposed acidic TME attributed quaternization tertiary amine Met, facilitating deep penetration. Subsequently, US irradiation, produced H2O2 based piezocatalysis BaTiO3, greatly enhanced Fenton reaction Fe3O4, thus boosting robust antitumor response. Furthermore, PD-L1 expression inhibited by local released Met further augment effect, achieving inhibitions primary metastatic tumors. Such combination piezocatalysis-enhanced chemodynamic Met-mediated downregulation provides promising strategy cancer immunotherapy.

Язык: Английский

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Enhancing Photothermal/Photodynamic Therapy for Glioblastoma by Tumor Hypoxia Alleviation and Heat Shock Protein Inhibition Using IR820-Conjugated Reduced Graphene Oxide Quantum Dots

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13543 - 13562

Опубликована: Март 7, 2024

We use low-molecular-weight branched polyethylenimine (PEI) to produce cytocompatible reduced graphene oxide quantum dots (rGOQD) as a photothermal agent and covalently bind it with the photosensitizer IR-820. The rGOQD/IR820 shows high conversion efficiency produces reactive oxygen species (ROS) after irradiation near-infrared (NIR) light for photothermal/photodynamic therapy (PTT/PDT). To improve suspension stability, was PEGylated by anchoring DSPE hydrophobic tails in DSPE-PEG-Mal, leaving maleimide (Mal) end group covalent binding manganese dioxide/bovine serum albumin (MnO2/BSA) targeting ligand cell-penetrating peptide (CPP) synthesize rGOQD/IR820/MnO2/CPP. As MnO2 can react intracellular hydrogen peroxide alleviating hypoxia condition acidic tumor microenvironment, efficacy of PDT could be enhanced generating more cytotoxic ROS NIR light. Furthermore, quercetin (Q) loaded rGOQD through π–π interaction, which released endosomes act an inhibitor heat shock protein 70 (HSP70). This sensitizes cells thermal stress increases mild-temperature PTT irradiation. By simultaneously incorporating HSP70 situ (MnO2), rGOQD/IR820/MnO2/Q/CPP overcome limitation PTT/PDT enhance targeted phototherapy vitro. From vivo study orthotopic brain model, administered tail vein injection cross blood–brain barrier accumulate intracranial tumor, laser shrink prolong survival times animals enhancing treat glioblastoma.

Язык: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Engineering nanoenzymes integrating Iron-based metal organic frameworks with Pt nanoparticles for enhanced Photodynamic-Ferroptosis therapy

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 645, С. 882 - 894

Опубликована: Май 7, 2023

Язык: Английский

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Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier

Small, Год журнала: 2023, Номер 19(45)

Опубликована: Июль 7, 2023

Abstract Glioblastoma is one of the most aggressive central nervous system malignancies with high morbidity and mortality. Current clinical approaches, including surgical resection, radiotherapy, chemotherapy, are limited by difficulty targeting brain lesions accurately, leading to disease recurrence fatal outcomes. The lack effective treatments has prompted researchers continuously explore novel therapeutic strategies. In recent years, nanomedicine made remarkable progress expanded its application in drug delivery, providing a new treatment for tumors. Against this background, article reviews delivery systems paper, mechanism nanomaterials crossing blood‐brain barrier summarized. Furthermore, specific nanotechnology glioblastoma discussed depth.

Язык: Английский

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