Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Prospects, advances and biological applications of MOF-based platform for the treatment of lung cancer

Biomaterials Science, Год журнала: 2024, Номер 12(15), С. 3725 - 3744

Опубликована: Янв. 1, 2024

Herein, we reviewed the recent development in use of MOF materials as a platform for treatment lung cancer.

Язык: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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Copper/gold-modified porphyrinic metal–organic frameworks nanoprobes for enhanced photodynamic/chemodynamic therapy

Chemical Engineering Journal, Год журнала: 2023, Номер 474, С. 145485 - 145485

Опубликована: Авг. 19, 2023

Язык: Английский

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Current status and prospects of MIL-based MOF materials for biomedicine applications

RSC Medicinal Chemistry, Год журнала: 2023, Номер 14(10), С. 1914 - 1933

Опубликована: Янв. 1, 2023

This review focuses on drug delivery systems based MIL-100(Fe) and MIL-101(Fe) that have made significant progress in chemodynamic therapy, photothermal photodynamic combined therapy.

Язык: Английский

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Recent advances in sonodynamic therapy by MOFs-based platforms for biomedical applications

Dyes and Pigments, Год журнала: 2023, Номер 219, С. 111596 - 111596

Опубликована: Авг. 1, 2023

Язык: Английский

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A pH-responsive bi-MIL-88B MOF coated with folic acid-conjugated chitosan as a promising nanocarrier for targeted drug delivery of 5-Fluorouracil

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 6, 2023

Cancer has remained one of the leading causes death worldwide, with a lack effective treatment. The intrinsic shortcomings conventional therapeutics regarding tumor specificity and non-specific toxicity prompt us to look for alternative mitigate these limitations. In this regard, we developed multifunctional bimetallic (FeCo) bi-MIL-88B-FC MOFs modified folic acid-conjugated chitosan (FC) as drug delivery systems (DDS) targeted 5-Fluorouracil (5-FU). bi-MIL-88B nanocarriers were characterized through various techniques, including powder X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, thermogravimetric analysis, Fourier transform infrared spectroscopy. Interestingly, 5-FU@bi-MIL-88B-FC showed slower release 5-FU due gated effect phenomenon endowed by FC surface coating compared un-modified 5-FU@bi-MIL-88B. pH-responsive was observed, 58% loaded released in cancer cells mimicking pH (5.2) only 24.9% under physiological (5.4). vitro cytotoxicity cellular internalization experiments revealed superiority highly potent DDS against folate receptor (FR) positive SW480 cells. Moreover, presence Fe Co structure, exhibited peroxidase-like activity chemodynamic therapy. Based on results, could serve promising candidate smart sustained selective targeting.

Язык: Английский

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Defective metal–organic framework derived from the waste plastic bottles for rapid and efficient nitroimidazole antibiotics removal

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 650, С. 836 - 845

Опубликована: Июль 12, 2023

Язык: Английский

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A metal-organic framework (MOF) built on surface-modified Cu nanoparticles eliminates tumors via multiple cascading synergistic therapeutic effects

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 298 - 312

Опубликована: Фев. 9, 2024

Язык: Английский

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