“Three‐in‐One” Nanozyme Composite for Augmented Cascade Catalytic Tumor Therapy

Advanced Materials, Год журнала: 2023, Номер 36(8)

Опубликована: Окт. 18, 2023

Abstract Cascade catalytic reaction exhibits simple procedure and high efficiency, such as that from the orderly assembly of different enzymes in biological systems. Mimicking natural cascade becomes critical, but is still challenging. Herein, single Au–Pt nanozyme reported with “three‐in‐one” functions to initiate conversions for O 2 supply mimic catalase, H production its glucose oxidase‐like property, • OH generation peroxidase chemodynamic therapy (CDT). Thus, complex cross‐talk among are avoided. To this end, metastable Cu NPs, scaffolds, used anchor ultrasmall nanozyme, while metal–organic framework (MOF) encapsulate tumor microenvironment response shielding protein adsorption. Pluronic F127 then modified on surface improve hydrophilicity biocompatibility composite. The endogenous acidity glutathione degrade MOF expose CDT. photothermal conversion ability also enhances CDT, 2+ ions consume GSH further CDT efficiency augmented therapy. a new paradigm provided drug‐free improving therapeutic efficacy minimizing side effects.

Язык: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Язык: Английский

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Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol detoxification

Nature Nanotechnology, Год журнала: 2024, Номер 19(8), С. 1168 - 1177

Опубликована: Май 13, 2024

Abstract Constructing effective antidotes to reduce global health impacts induced by alcohol prevalence is a challenging topic. Despite the positive effects observed with intravenous applications of natural enzyme complexes, their insufficient activities and complicated usage often result in accumulation toxic acetaldehyde, which raises important clinical concerns, highlighting pressing need for stable oral strategies. Here we present an solution detoxification employing biomimetic-nanozyme amyloid hydrogel as orally administered catalytic platform. We exploit fibrils derived from β-lactoglobulin, readily accessible milk protein that rich coordinable nitrogen atoms, nanocarrier stabilize atomically dispersed iron (ferrous-dominated). By emulating coordination structure horseradish peroxidase enzyme, single-site nanozyme demonstrates capability selectively catalyse oxidation into acetic acid, opposed more acetaldehyde. Administering gelatinous mice suffering intoxication significantly reduced blood-alcohol levels (decreased 55.8% 300 min post-alcohol intake) without causing additional acetaldehyde build-up. Our further protective effect on liver, while simultaneously mitigating intestinal damage dysbiosis associated chronic consumption, introducing promising strategy detoxification.

Язык: Английский

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Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13353 - 13383

Опубликована: Март 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Язык: Английский

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Oxidase mimicking nanozyme: Classification, catalytic mechanisms and sensing applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 520, С. 216166 - 216166

Опубликована: Авг. 22, 2024

Язык: Английский

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Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 22, 2024

Abstract The inactivation of natural enzymes by radiation poses a great challenge to their applications for radiotherapy. Single-atom nanozymes (SAzymes) with high structural stability under such extreme conditions become promising candidate replacing shrink tumors. Here, we report CuN 3 -centered SAzyme (CuN -SAzyme) that exhibits higher peroxidase-like catalytic activity than 4 counterpart, locally regulating the coordination environment single copper sites. Density functional theory calculations reveal active moiety confers optimal H 2 O adsorption and dissociation properties, thus contributing enzymatic -SAzyme. introduction X-ray can improve kinetics decomposition Moreover, -SAzyme is very stable after total dose 500 Gy, without significant changes in its geometrical structure or environment, simultaneously still retains comparable relative enzymes. Finally, this developed remarkable radioresistance be used as an external field-improved therapeutics enhancing radio-enzymatic therapy vitro vivo. Overall, study provides paradigm developing SAzymes improved through local manipulation over enzymes, example, sensitizers cancer therapy.

Язык: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Multifaceted Catalytic Glucose Depletion and Reactive Oxygen Species-Scavenging Nanoenzyme Composite Hydrogel for Facilitating Diabetic Bone Regeneration

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Regeneration of diabetic bone defects remains a formidable challenge due to the chronic hyperglycemic state, which triggers accumulation advanced glycation end products (AGEs) and reactive oxygen species (ROS). To address this issue, we have engineered bimetallic metal–organic framework-derived Mn@Co3O4@Pt nanoenzyme loaded with alendronate Mg2+ ions (termed MCPtA) regulate microenvironment recover osteogenesis/osteoclast homeostasis. Notably, Mn atom substitution in Co3O4 nanocrystalline structure could modulate electronic significantly improve SOD/CAT catalytic activity for ROS scavenging. By integration GOx-like Pt nanoparticles, MCPtA achieved effective multiple cascade performance that facilitated clearance glucose ROS. Furthermore, was encapsulated within glucose-responsive hydrogel cross-linked via borate ester bond, termed PAM, evaluate potential composite cranial defect repair rats. The vitro/vivo experiments as well RNA sequencing analysis demonstrated disrupt glucose-ROS-induced inflammation promoted osteogenesis angiogenesis, consequence, improving therapeutic effects regeneration. This study provided crucial insights into nanoenzyme-mediated microenvironmental regulation

Язык: Английский

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Consolidated sustainable organic nanozyme integrated with Point-Of-Use sensing platform for dual agricultural and biological molecule detection

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159560 - 159560

Опубликована: Янв. 1, 2025

Язык: Английский

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