Angewandte Chemie,
Год журнала:
2023,
Номер
136(8)
Опубликована: Ноя. 21, 2023
Abstract
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function‐oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF‐based
anticancer
nanomedicines
bringing
closer
to
trials.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(22), С. 9167 - 9176
Опубликована: Май 18, 2024
The
detection
of
virus
RNA
in
wastewater
has
been
established
as
a
valuable
method
for
monitoring
Coronavirus
disease
2019.
Carbon
nanomaterials
hold
potential
application
separating
owing
to
their
effective
adsorption
and
extraction
capabilities.
However,
carbon
have
limited
separability
under
homogeneous
aqueous
conditions.
Due
the
stabilities
nanostructure,
it
is
challenge
efficiently
immobilize
them
onto
magnetic
beads
separation.
Here,
we
develop
porous
agarose
layered
graphene
oxide
(GO)
nanocomposite
that
prepared
by
agglutinating
ferroferric
(Fe
Analytical Chemistry,
Год журнала:
2024,
Номер
96(27), С. 10953 - 10961
Опубликована: Июнь 26, 2024
Detection
of
circulating
tumor
DNA
(ctDNA)
in
liquid
biopsy
is
great
importance
for
diagnosis
but
difficult
due
to
its
low
amount
bodily
fluids.
Herein,
a
novel
ctDNA
detection
platform
established
by
quantifying
amplification
by-product
pyrophosphate
(PPi)
using
newly
designed
bivariable
lanthanide
metal–organic
framework
(Ln-MOF),
namely,
Ce/Eu-DPA
MOF
(CE-24,
DPA
=
pyridine-2,6-dicarboxylic
acid).
CE-24
exhibits
ultrafast
dual-response
(fluorescence
enhancement
and
enzyme-activity
inhibition)
PPi
stimuli
virtue
host–guest
interaction.
The
applied
detecting
colon
carcinoma-related
(KARS
G12D
mutation)
combined
with
the
isothermal
nucleic
acid
exponential
reaction
(EXPAR).
triggers
generation
large
PPi,
quantification
achieved
through
ratio
fluorescence/colorimetric
dual-mode
assay
PPi.
combination
EXPAR
sensing
allows
method
be
low-cost,
convenient,
bioreaction-compatible
(freedom
from
interference
bioreaction
systems),
sensitive
(limit
down
101
fM),
suitable
on-site
detection.
To
best
our
knowledge,
this
work
first
application
Ln-MOF
detection,
it
provides
universal
strategy
rapid
biomarkers
point-of-care
scenarios.
Journal of Materials Chemistry C,
Год журнала:
2023,
Номер
11(45), С. 15841 - 15847
Опубликована: Янв. 1, 2023
Amide
solvents
were
used
as
terminal
coordinated
molecules
to
tune
the
pore
sizes
of
Ca-MOFs,
achieving
size
controllable
fluorescence
sensing
performance
towards
trinitrophenol
(TNP).
Dalton Transactions,
Год журнала:
2024,
Номер
53(26), С. 10805 - 10813
Опубликована: Янв. 1, 2024
Polyoxometalates
(POMs)
have
drawn
significant
attention
on
account
of
their
structural
designability,
compositional
diversity
and
great
potential
applications.
As
an
indispensable
branch
POMs,
selenotungstates
(SeTs)
been
synthesized
extensively.
Some
SeTs
applied
as
sensing
materials
for
detecting
biomarkers
(
Optical
biosensors
that
consist
of
a
light
source,
optical
elements,
and
photodetector
are
used
to
detect
chemical
biological
species
pollutants.
This
Tutorial
discusses
the
fundamental
details
biosensing
techniques
include
materials,
working
principle,
components,
sensor
configurations,
parameters,
future
prospects.
plasmonic
[surface
plasmon
resonance
(SPR)
localized
SPR],
fluorescence,
luminescence,
Raman
scattering,
colorimetric,
interferometric
methods.
Bioreceptor
elements
play
significant
role
in
detecting
specific
analyte
can
be
synthetic
or
natural.
Surface
functionalization
bind
bioreceptor
on
surface,
control
orientation,
have
been
discussed
detail.
The
possibility
integration
chip,
develop
wearable,
implantable
sensors,
associated
challenges
fully
demonstrated.
provides
valuable
insights
into
present
state
directions
for
various
applications.
